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Company: PhylloTech Agency/Program/Year/Phase: HHS / SBIR / 2012 / 1
Abstract: DESCRIPTION (provided by applicant): This Small Business Innovation Research Phase I project will investigate the feasibility of utilizing a stabilized, cadmium-binding antibody to sequester cadmium in plant trichomes. Heavy metals such as cadmium are ubiquitous contaminants in soil surrounding… more
Company: CARMOT THERAPEUTICS, INC. Agency/Program/Year/Phase: HHS / SBIR / 2012 / 1
Abstract: DESCRIPTION (provided by applicant): Type 2 diabetes mellitus is one of the most challenging health problems of the 21st century. Global health care expenditures to treat diabetes and its complications are estimated to have been 376 billion in 2010, of which 198 billion was spent in the United… more
Company: J AND J SOLUTIONS, INC. Agency/Program/Year/Phase: HHS / SBIR / 2012 / 2
Abstract: DESCRIPTION (provided by applicant): Chemotherapy drugs tend to be highly cytotoxic and genotoxic, with well-documented carcinogenic, mutagenic, and teratogenic effects. Long-term occupational exposure to these highly toxic drugs presents serious health risks (e.g., cancers, infertility,… more
Company: RXI PHARMACEUTICALS CORPORATION Agency/Program/Year/Phase: HHS / SBIR / 2012 / 1
Abstract: DESCRIPTION (provided by applicant): The study of retinoblastoma, a childhood tumor, has provided numerous insights into cancer biology. Perhaps most significantly, this work has revealed that cancers can develop in response to mutations in tumor suppressor genes. Tumor suppressor mutations account… more
Company: CRESTONE, INC. Agency/Program/Year/Phase: HHS / SBIR / 2012 / 2
Abstract: DESCRIPTION (provided by applicant): The alarming increase in incidence of infections caused by drug-resistant bacteria has created an urgent need for new antibacterial agents. We are developing a novel class of small molecule antibiotics ( TZUs ) targeting PolC, the replicative DNA polymerase in… more
Company: NEURODX DEVELOPMENT, LLC Agency/Program/Year/Phase: HHS / SBIR / 2012 / 1
Abstract: DESCRIPTION (provided by applicant): This Phase I SBIR will develop ICPCheck, the first long term implantable, non-invasively readable intracranial pressure (ICP) monitor for hydrocephalus patients. This device will result in improved clinical management of hydrocephalus by providing a rapid and… more
Company: POLGENIX, INC. Agency/Program/Year/Phase: HHS / SBIR / 2012 / 2
Abstract: DESCRIPTION (provided by applicant): Polgenix, Inc. is developing an imaging instrument, the 2-photon ophthalmoscope , or 2PO , with the capability for non-invasive, repetitive and high-resolution imaging of biochemical processes within human retina.This device will allow early detection of… more
Company: PROCURE TREATMENT CENTERS, INC. Agency/Program/Year/Phase: HHS / SBIR / 2012 / 1
Abstract: DESCRIPTION (provided by applicant): In recent years there has been increased interest throughout the world in the use of proton radiation therapy for treatment of cancer. Currently, there are only 9 operational centers in the US that treat a total of about 7,000 patients per year comprising less… more
Company: DOUBLE S INSTRUCTIONAL SYSTEMS Agency/Program/Year/Phase: HHS / SBIR / 2012 / 1
Abstract: DESCRIPTION (provided by applicant): The problem of overweight children with intellectual disabilities (ID) has many adverse medical and psychological effects and is of growing concern among professionals in the disability research and advocacy arenas. Toaddress this issue, we propose to develop… more
Company: PHARMATECH, INC. Agency/Program/Year/Phase: HHS / SBIR / 2012 / 2
Abstract: DESCRIPTION (provided by applicant): The American Cancer Society estimates that more than 1.5 million new cancer victims will be diagnosed this year in the U.S., and that ~572,000 Americans will die of cancer in 2011.1 More than 13 million Americans are living today with a history of cancer, and… more
Company: INTELLISPEAK, LLC Agency/Program/Year/Phase: HHS / SBIR / 2012 / 2
Abstract: DESCRIPTION (provided by applicant): The proposed effort is aimed at the development and evaluation of a wireless electronic location system for reporting the location of individuals with autism and other cognitive disabilities, who may wander or elope. This is a very vexing and routine problem for… more
Company: INTELLISPEAK, LLC Agency/Program/Year/Phase: HHS / SBIR / 2012 / 1
Abstract: DESCRIPTION (provided by applicant): The proposed effort is aimed at the evaluation of a wireless electronic location system for reporting the location of individuals with Alzheimer's Disease and other Dementia (ADOD), who tend to wander or elope. This isa very vexing and routine problem for… more
Company: CYNVENIO BIOSYSTEMS, INC. Agency/Program/Year/Phase: HHS / SBIR / 2012 / 2
Abstract: DESCRIPTION (provided by applicant): Aptamers are nucleic acid based affinity reagents that can be selected in vitro from large combinatorial libraries. As an affinity reagent they have inherent advantages as they are chemically synthesized, thermostable,immunologically neutral, significantly… more
Company: CardioSolv Agency/Program/Year/Phase: HHS / SBIR / 2012 / 1
Abstract: DESCRIPTION (provided by applicant): Heart failure is a major cause of morbidity and mortality, contributing significantly to global health expenditure. Heart failure patients often exhibit contractile dyssynchrony, which diminishes cardiac systolic function. Cardiac resynchronization therapy (CRT)… more
Company: WISDOM TOOLS Agency/Program/Year/Phase: HHS / SBIR / 2012 / 2
Abstract: DESCRIPTION: PROJECT SUMMARY/ABSTRACT. This Phase II SBIR project, Game FACTS (Fun, Adaptable-Content Trainer Suite): The Use of Microgames as a Supplemental Learning Tool for Worker Health and Safety Training builds upon the work of the previously fundedPhase I SBIR project Micro-games for WMD… more
Company: DMX, INC. Agency/Program/Year/Phase: HHS / SBIR / 2012 / 1
Abstract: DESCRIPTION (provided by applicant): In the US, about 36,000 deaths occur each year due to influenza and its associated diseases, and 85% of these deaths are in the elderly population. Immunization with flu vaccine is considered the best way to prevent seasonal epidemics and pandemics of influenza.… more
Company: SIMQUEST , LLC Agency/Program/Year/Phase: HHS / SBIR / 2012 / 1
Abstract: DESCRIPTION (provided by applicant): Project Summary/Abstract Methamphetamine (meth), the fastest-growing illicit drug in the United States, is manufactured in makeshift laboratories using highly flammable and toxic ingredients. Most meth labs are discovered when fires, explosions, or medical… more
Company: SIMQUEST , LLC Agency/Program/Year/Phase: HHS / SBIR / 2012 / 1
Abstract: DESCRIPTION (provided by applicant): Improvements in pre-hospital trauma life support in the past 20 years have led to impressive enhancement in patient survival. These achievements have come as the result of improved equipment, transport logistics, assessment/treatment protocols, and training of… more
Company: CYTEL, INC Agency/Program/Year/Phase: HHS / SBIR / 2012 / 2
Abstract: DESCRIPTION (provided by applicant): Categorical outcomes are ubiquitous in biomedical research, and generalized linear models (GLMs) represent the most widely applied methodology for testing associations between categorical variables and fixed investigative factors. Logistic regression in… more
Company: K AND A WIRELESS, LLC Agency/Program/Year/Phase: HHS / SBIR / 2012 / 2
Abstract: DESCRIPTION (provided by applicant): This SBIR project is developing a system capable of remotely monitoring, in real-time, the adherence of an HIV patient to Antiretroviral therapy (ART). ART is a medication regimen that once started, needs to be followedfor the rest of the patient's life. ART… more
Company: FLUENTIAL, INC. Agency/Program/Year/Phase: HHS / SBIR / 2012 / 2
Abstract: DESCRIPTION (provided by applicant): The purpose of this SBIR study is to develop and evaluate a real-time speech translation system to facilitate Medication Therapy Management (MTM) of patients with diabetes who primarily speak Spanish. We plan to accomplish this by (1) Collecting 1000 MTM… more
Company: HEARTHSTONE ALZHEIMER CARE, LTD Agency/Program/Year/Phase: HHS / SBIR / 2012 / 2
Abstract: DESCRIPTION (provided by applicant): Market potential exists for development of works of drama that can be performed in facilities providing care for persons with dementia, and which can involve such residents interactively. Therefore, the purpose of thisPhase 2 project is to refine two plays… more
Company: HEARTHSTONE ALZHEIMER CARE, LTD Agency/Program/Year/Phase: HHS / SBIR / 2012 / 2
Abstract: DESCRIPTION (provided by applicant): An estimated 5.4 million Americans are currently suffering from Alzheimer's disease (AD), and AD cases are expected to rise at an alarming rate, so market potential exists for products, approaches, and/or training thatcan help treat and/or circumvent the… more
Company: MC3, INC. Agency/Program/Year/Phase: HHS / SBIR / 2012 / 1
Abstract: DESCRIPTION (provided by applicant): Dentin hypersensitivity (DH) is a common problem and the treatment modalities are, if they work at all, short lived. The object of this project is t produce a product that can occlude patent dentinal tubules (the causeof DH) and adhere to the wet interior… more
Company: MC3, INC. Agency/Program/Year/Phase: HHS / SBIR / 2012 / 1
Abstract: DESCRIPTION (provided by applicant): Diabetic Retinopathy (DR), a vision threatening complication of diabetes, can be managed more effectively if detected early. We propose to enable such early diagnosis by developing a portable retinal imaging instrument- LSC EYE - that will, for the first time,… more
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