Abstract:… with Dr. Warner and Dr. Cenk Ayata of Massachusetts General Hospital (MGH). Upon completion of the pre-clinical studies, we propose to enter the clinic by conducting a dose-escalating safety trial in stroke patients at MGH with Dr Karen Furie, Director MGH Stroke Services.… more
Abstract:…. All products will be refined to be publish-quality. Collectively, this augmentation of the innovativeALEXSA research instrument into a tool that provides state-of-the-art assessment will assist professionalism meeting mandates for 6 million annual early intervention services… more
Abstract:… II design of the VOTA commercial product and human participant trials of the effectiveness of VOTA therapy in both clinical and home health settings. CommercialOpportunity: Participation by HealthSouth, the nation's largest provider of rehabilitative healthcare services… more
Abstract:… and scalable data storage mechanisms andinterfaces to access other software tools for Bayesian adaptive design and interim analysis. The technical development will enable us to form a contracted research organization (CRO). It will offer cost-effective data services, fully… more
Abstract:… behavior change strategies are essential. In this study, our research team proposes to develop the Behavioral Brand Builder (B3). B3 is a user- friendly, step-by-step training guide with integrated tools for development of branded prevention programs and services based on… more
Abstract:…, at a fraction of the cost of in-person or group approaches. If proven effective at improving weight loss and glycemic control in a randomized trial, it could become an important component of the standard of care for prediabetics as a stand-alone service, as a… more
Abstract:…, 3) test the durability of immune protection and the cross-subtype protection, 4) evaluate the safety (pulmonary histopathology) of the RSV vaccine candidate in both BALB/c mouse and the cotton rat models. PUBLIC HEALTH RELEVANCE: The Public Health Service… more
Abstract:… approaches to rheumatoid arthritis, particularly cost-effective, steroid-sparing small molecule therapies, are in great demand. The broad long-term objective of this proposal is to advance a small molecule rheumatoid arthritis therapeutic into clinical service. This… more
Abstract:…ll be tested through theuse of a blind study. Completion of these aims will encourage further discussions with partnering companies in order to develop a kit that can detect the validated biomarkers of cardiotoxicity. Stemina will then utilize this kit to market a service to… more
Abstract:DESCRIPTION (provided by applicant): The science of protecting avulsed teeth has progressed little in the past 10 years. While commercial solutions are available, most simply consist of a pH balanced salt solution. Several peer-reviewed citations in the last two years have compared the efficacy of… more
Abstract:DESCRIPTION (provided by applicant): There is increasing utilization of flow cytometry in both basic and applied research to accomplish diagnostic assays. One such area of research is the investigation of circulating cells that have detached from tumors. Another very active and contemporary area is… more
Abstract:… This model will be based on the unique databases we create which, together the development of software dedicated to mining public and proprietary cardiac databases will dramatically increase productivity of pre-clinical cardiac safet screening. The set of services and products… more
Abstract:…tal health interventions supporting both short- and long-term reintegration of veterans of OIF and OEF into their communities and significant relationships. Innovative approaches are needed to support the well-being of veterans who may not access or be reached by formal services… more
Abstract:… providing power for an increasing range of portable medical devices. With their light weight and higher voltages, device capabilities have improved within acceptable weight limits for portability. However, the batteries' issues with reliability, safety, service life and… more
Abstract:… to the Center for Substance Abuse Prevention, Report on Best Practices for Responsible Retailing. The model shows retailers specific measures they can adopt to improve their age-verification practices. This project will enable the applicant, RRF Field Services LLC, to… more
Abstract:… of DMetrix, namely the development of fast, parallel image-capture instruments. A significant part of the Phase II effort will be directed at making the proposed instrument manufacturable at a minimum cost of goods sold (COGS) and optimized for serviceability. DMetrix has… more
Abstract:… interventions are effective in ameliorating conduct disorders, substance abuse, HIV-risk, and related adolescent problem behaviors. During periods of economic turmoil, however, major obstacles such as affordability impede the effective delivery of support services.… more
Abstract:…, this IBME may be also useful as a template for future training of providers of caregiving support to persons with chronic diseases other than ADRD. PUBLIC HEALTH RELEVANCE: This Phase II effort completes and evaluates an Internet-based training for social service… more
Abstract:… receiving its benefits,including geographic distance; impediments to older adults leaving their homes; and travel considerations for counselors which make it impossible to provide the NYUCI. This innovative Fast Track application has massive implications for social service… more
Abstract:… this Phase II Small Business Technology Transfer (STTR) proposal is to conduct a randomized field test of the rechargeable incentive card (RIC) system developed in Phase I, and to execute a detailed plan to commercialize the finalized set of products and services. The RIC… more
Abstract:… This project proposes to develop a secure, web-based resource to provide therapists with instructional materials for scheduling tailored, interactive text messages for delivery to depressed adolescents in treatment. The content of the selectable, short message service (SMS)… more
Abstract:… for tooth decay rely on surgical removal of decayed enamel and dentin by dental instruments and filling of the prepared cavity with artificial materials including amalgam and composite resin. However, current restorative dental treatmentsby artificial fillers have finite … more
Abstract:… meaningful impact on cognition and on the lives of schizophrenia patients. PUBLIC HEALTH RELEVANCE: Schizophrenia is a serious mental illness that affects approximately three million Americans and costs about 100 billion a year for direct treatment, community services… more
Abstract:… for targeted exploration of the underlying biology. This project directly addresses the need to make what the FDA terms IVDMIA (In-Vitro DiagnosticMultivariate Index Assays) transparent and interpretable, and is thus an opportunity to improve analysis services or products… more
Abstract:… improved awareness and identification accounted for some of this increase, the CDC could not rule out a true increase in risk, particularly among boys, who are now 4.5 times more likely than girls to be diagnosed with an autism spectrum disorder (ASD). Services for children… more
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