Abstract:It is well known that many chemicals may disturb the endocrine system. These endocrine-disrupting chemicals (EDCs) can cause adverse effects on human health and wildlife. In 1996, Congress directed the U.S. Environmental Protection Agency (EPA) to develop the Endocrine Disruptor Screening Program… more
Abstract:Advanced Technologies Group, Inc. proposes a Solid-state, Lightweight, Active-balance-system, Powered-by-light, (SLAP). The SLAP balancer will reduce or eliminate drive shaft vibrations caused by rotational dynamics of the Joint Strike Fighter (JSF) liftfan drive shaft. Reduced shaft vibration… more
Abstract:While the phenomenon of suspended animation has not been widely studied in humans, there are many anecdotal and medically verified examples of humans being in a state that is comparable to suspended animation when they have been accidentally nearly frozenfor short periods of time. There could be… more
Abstract:Agave BioSystems proposes to develop and demonstrate an innovative Organic Thin Film Transistor (OTFT) to detect cell characteristics without the need for cell labeling for use in microfluidic flow cytometers. This sensor would be able to detect count all cells, whether the cells are fluorescently… more
Abstract:Current methods used for the destruction of CW agents are cumbersome, require extensive capital equipment such as incinerators and water reactors and pose potential environmental problems themselves. A novel approach for the destruction of CW agentsinvolves genetically engineering microorganisms to… more
Abstract:Agave BioSystems has been highly successful in accomplishing the Phase I objectives. In this Phase II proposal, Agave BioSystems will build upon the results generated in the Phase I to isolate additional shikimate pathway genes. We will continue to usestate-of-the-art-bioinformatics computational… more
Abstract:It is clear now that deadly biological materials can easily be spread throughout the U.S., and that there are few methods currently available to rapidly detect and identify these bioterrorist agents. Significant resources have been applied to thedevelopment of DNA diagnostic systems for this… more
Abstract:Agave BioSystems, in collaboration with Dr. Robert Boyd, of the Institute of Optics at the University of Rochester, proposes to develop an ultra sensitive and highly specific biosensor based on whispering gallery mode (WGM) resonator technology forbioterrorist and biowarfare agent detection. This… more
Abstract:DESCRIPTION (provided by applicant):
Fluorescent semiconductor nanocrystals or quantum dots have many properties that make them superior to traditional dyes as fluorescent markers. Quantum dots have higher extinction coefficients making them brighter than traditional dyes (up to 1000 times… more
Abstract:Malaria is responsible for 300 million cases a year, resulting in 1 million deaths. From a military perspective, maintaining bases in regions where the disease is endemic puts troops at risk for infection. Whether for civilian or military populations,the fact remains that insecticide tolerant… more
Abstract:DESCRIPTION (provided by applicant):
Research Objectives: Determine the safety, pharmacokinetics, pharmacodynamics, and efficacy of topical recombinant human lactoferrin (rhLF) in promoting healing in diabetic ulcers.
There are 7.5 million US patients with chronic skin wounds with annual… more
Abstract:This program addresses a new approach to IR imager that closely mimics biological organisms sense principals, having advantages in sensitivity, energy efficiency, reliability, and cost as compared with the competitive approaches. The innovation is based onincorporation of sensitive polymer-molecular… more
Abstract:Agiltron proposes a new concept for room temperature infrared imaging, which has the extraordinary potential of meeting the stringent requirement for monitoring the image projectors under intense EMI interference. This real-time monitoring system can beused to maintain the calibration of… more
Abstract:Lasercomm offers attractive benefits of energy efficient, small size and weight, as well as resistant to detection and jam. However, lasercomm requires high accuracy pointing systems due to the much narrower beam divergence compared to conventional RFtechnology. Although mechanical beam steering… more
Abstract:The present invention provides an inexpensive and low loss fiberoptic manifold for lightweight, high-efficiency, electronically steerable, phased-array antennas. Our approach is sate-of-the-art in design and closely coupled with proven volume fiber optic component manufacturing techniques, holding a… more
Abstract:This proposal addresses an unconventional photonic approach to the next generation IR scene generator. The revolutionary IR scene generator design intrinsically has advantages in speed, compactness, light intensity, temperature range, spatial resolution,background noise, reliability, and cost as… more
Abstract:This program addresses the development of a cutting edge optical switching technology for microchip laser. Leveraged on our industry leading solid-state optical switch commercialization expertise, AGILTRON Inc. is developing and perfecting a uniqueoptoceramic 1x4 switch. This program is focused on… more
Abstract:This program addresses the development of a cutting edge optical switching technology for microchip laser. Leveraged on our industry leading solid-state optical switch commercialization expertise, AGILTRON Inc. is developing and perfecting a uniqueoptoceramic 1x4 switch. This program is focused on… more
Abstract:This program addresses a revolutionary low cost manufacturing technology of digitally switchable fiberoptic true time delay manifold for high performance phased array antenna. By using an improved electro-optic material system, the proposed integrateddevice will provide sub-microsecond high… more
Abstract:NON-TECHNICAL SUMMARY: Nostoc commune is an edible cyanobacterium forming the spherical macrocolony, which is used as a potent herbal medicine and dietary supplement. Due to its nutraceutical and pharmacological value, the N. commune has received increasing attention, and the market demand has grown… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project proposes to improve the bioavailability of astaxanthin from the green algae, Haematococcus pluvialis, through molecular genetic manipulation of the organism. Natural astaxanthin is a potent bioactive antioxidant and offers tremendous… more
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