Abstract:DESCRIPTION (provided by applicant):
Research Objectives: Determine the safety, pharmacokinetics, pharmacodynamics, and efficacy of topical recombinant human lactoferrin (rhLF) in promoting healing in diabetic ulcers.
There are 7.5 million US patients with chronic skin wounds with annual… more
Abstract:DESCRIPTION: Oral mucositis is a major dose-limiting toxic effect of intensive cancer chemotherapy and radiotherapy. In addition to the morbidity directly caused by severe oral mucositis, it can cause secondary morbidities by limiting oral intake or even lead to dose reduction or delay in further… more
Abstract:DESCRIPTION (provided by applicant): The purpose of this research is to extend work to determine the efficacy of orally administered recombinant human lactoferrin (rhLF) in an established primate model of asthma. Asthma is one of the most prevalent chronic inflammatory diseases in the United States… more
Abstract:DESCRIPTION (provided by applicant): This feasibility study is based on our hypothesis that recombinant human lactoferrin [rhLF] can prevent or reduce severity of necrotizing enterocolitis [NEC]. NEC is mainly a disease of very low birth weight [VLBW] human infants. It is a leading cause of… more
Abstract:DESCRIPTION (provided by applicant): Pain is a serious, debilitating condition that is under-treated because of the dose-limiting side effects of currently used opiate drugs such as morphine. Enkephalin is an endogenous opiate peptide, which induces analgesia, but unlike morphine it has few, if any… more
Abstract:Phase II of the MATES project will extend our current system for road sign detection, recognition and translation on handheld devices in several novel and innovative directions. Our core application will be document triage, where the soldier obtains a gist translation or keyword profile of a… more
Abstract:This Small Business Innovation Research (SBIR) Phase II research project develops the concept of using hand-held, mobile devices to link the physical world to information networks using advanced pattern and symbol recognition technology that will be deployed on the mobile device. The proposed mobile… more
Abstract:Currently, the benefits of objective trail information are limited in rural areas because the team of people required to complete the UTAP is difficult and costly to assemble. The USDA Forest Service is responsible for the management of 133,000 miles of trails and public lands with trails held by… more
Abstract:The overall goal of Phase II is to develop a powerful tool to correlate large amounts of asynchronous data in near real-time and meet current operational requirements for the Joint Command and Control Community for rapid, accurate Battle Damage Assessment and operational assessment. The team will… more
Abstract:DESCRIPTION (provided by applicant): The overall goal of this project is the development of a fully automated, wireless ethernet capable, near realtime, field deployable immunoassay-based analysis system for the concurrent, ultra low-level detection of biowarfare agents in air or water by using… more
Abstract:DESCRIPTION (provided by applicant):
This is a Phase II SBIR proposal for completing the development of a comprehensive collection of statistical tools embedded in LogXact, in EGRET, in SAS as PROCs and in SPLUS as functions. This set of tools will compute maximum likelihood estimates for… more
Abstract:DESCRIPTION (provided by applicant): This is a Phase I SBIR proposal for the development of computer software performing small sample exact inference for correlated categorical data. Such data are now common in many, biomedical areas of research, such as genetics, ophthalmology, and teratology. In… more
Abstract:Programs such as Airborne Laser and Space-Based Laser require highly mass efficient structures. Because of their high specific strength and stiffness this naturally leads to graphite fiber reinforced polymer (GFRP) materials for many system components. In fluid storage tank applications GFRP… more
Abstract:Rural communities in forested areas need to thin small diameter trees from overstocked stands. The smallwood does not have adequate market demand to support the cost of collection and delivery. This project explores the opportunity to market more smallwood to retail customers and urban markets by… more
Abstract:The primary objective of Phase II is to use refined computer models developed during phase I to help identify performance characteristics of band tracked vehicles, select a wheeled vehicle platform suitable for the application, and specify band track components. Instrumented testing will then… more
Abstract:This proposal is directed at a fundamental change in military trucks by designing driveline systems as a complete lightweight module manufactured from selectively chosen lightweight components. Current driveshafts, differentials, transfer cases, axles, and brake systems are typically bolted… more
Abstract:The Army's need for high energy-density, lightweight power sources gives incentive to the search for creative fuel cell concepts and approaches that can potentially reduce size, weight, and complexity. Success in such efforts would certainly have significant spin-off opportunities in the commercial… more
Abstract:The Phase I results give encouragement Phase II goals of a specific energy of 1 kWhr/kg and an energy density of 1 kWh/liter for a 20 W system and a 1 kWh mission are achievable under the following conditions: optimization of cathode catalyst and catalyst layer formulations to obtain higher and… more
Abstract:This SBIR project is proposed to commercialize a novel method referred as PDESA for revealing patient's individual haplotypes. Our preliminary data shown that PDESA could reveal haplotypes of sequences of 134kb in length, which is about three times longer than the longest sequence haplotyped using… more
Abstract:The proposed innovations conform precisely to the technology needs described in Subtopic T5.02, Robotics and Virtual Digital Human Technologies. ?Two potential areas for research are the ever-evolving robotics and 3-D simulation technologies providing operational robustness and intelligence.? Our… more
Abstract:The integration of the analysis tools with the advanced visualization capabilities in The Intelligent Flight Support System (IFSS) can provide a unique method for investigating dynamic spatial problems. The IFSS will use a simple joystick driven navigation paradigm to navigate throughout the… more
Abstract:In our Phase II effort, we propose to investigate the basic concepts required to quickly measure physiological signals, develop an advanced human-computer collaborative system, and design a software developers kit (SDK) that offers system designers precise control over event timing and stimulus… more
Abstract:DESCRIPTION (provided by applicant): Simultaneously recorded EEG/fMRI measures of higher order cognitive processing in the brain during complex task performance have been difficult to establish. The problems are due to the difficulty of collecting the EEG in a high-gradient field and the complexity… more
Abstract:72192-Future high field (15+T) dipole magnets will require superconductors with high current density and lower costs. This project will develop technology for lowering the cost of the Nb/Cu filaments that go into the internal-Sn subelments and for increasing the Nb/Cu ratio of these filaments. … more
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