Abstract:DESCRIPTION (provided by applicant): Although numerous advances have been made in the treatment of severe hemorrhage, current blood plasma substitutes do not address new insights in resuscitation medicine. Research in fluid technologies and vascular response following significant pre-hospital… more
Abstract:Injuries to soft tissues in extremities represent a high percentage of battlefield wounds in recent conflicts. Therapies for restoring function to injured muscle are needed for Wounded Warriors suffering from debilitating and sometimes disfiguring musculoskeletal injuries. Regenerative medicine… more
Abstract:Skeletal muscle injury is a significant challenge to warfighters due to the severity of the injuries often caused by Improvised Explosive Devices. Currently, there are few viable clinical treatment options for these types of injuries. Keratin hydrogels offer a solution to these challenges as… more
Abstract:The improvement of body armor, equipment, and decreases in patient transport times have dramatically improved survival of combat injuries. However, data suggests that future conflicts will require more aggressive wound management at the point of injury to deal with more complex wounds particularly… more
Abstract:This project develops and tests a multimedia software application to provide an independently usable format for improving knowledge of voting and election processes for persons with intellectual disabilities. During Phase I, a prototype is developed and evaluated to determine the feasibility of the… more
Abstract:This project develops a cloud-based system for managing and delivering “on demand” activity prompts to individuals with intellectual disabilities along with a comprehensive, automated reporting system to enable reliable remote notifications to facilitate monitoring of task compliance. Pictures,… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project concerns the development of an optical fiber biosensor platform that achieves exceptionally high sensitivity through use of a nanoscale, high refractive index, self-assembled polymer coating on the cladding surface. A rapid, specific,… more
Abstract:ABSTRACT: The extreme toxicity of organophosphate (OP) chemical warfare agents (CWA) is due to their specific, rapid, and irreversible reaction with cholinesterase enzymes. A significant portion of this reactive nature of OP agents is directly due to the unique metabolically active environment… more
Abstract:Dried blood spots (DBS) analysis has many advantages over standard liquid blood sample testing including: small sample size, ease of blood sampling, room temperature storage, minimal storage size requirement, and ease of shipping. Although these advantages are significant, there are still problems… more
Abstract:Agave BioSystems proposed to develop a system of Rapidly Adaptable Nanotherapeutics (RANT) by combining advanced bioformatics, with DNA-based nanoparticles, peptide nucleic acid (PNA) antisense oligonucleotides, and cell permeating peptides (CPPs). Advanced bioinformatics computing will allow for… more
Abstract:One major cause of the widespread of drug-resistant and virulent bacteria pathogen is the horizontal gene transfer of resistance and virulence genes in the form of plasmids. As proof-of concept for this Phase I effort, Agave BioSystems proposes to develop combinatorial therapeutics by inhibiting… more
Abstract:Wounds infected with drug-resistant Gram-negative bacteria can increase morbidity, hospital length of stay and cost. Among these Klebsiella pneumoniae and Pseudomonas aeruginosa have become important causes of concern in military personnel wounded in battlefield. New classes of antimicrobial agents… more
Abstract:With no clinically approved antiviral therapy available for treatment of flavivirus infections, the development of efficient vaccines and antiviral agents for prevention and treatment of infections is an urgent health priority. A combination of structure-based in silico models, in vitro and… more
Abstract:Bacterial enteric pathogens causing travelers"diarrhea (TD) in developing countries include enterotoxigenic E. coli (50%), Camplyobacter jejuni, Shigella sonnei and Shigella flexneri, while Norovirus is a common viral cause. High risk regions for TD include areas where US service members are… more
Abstract:Field testing of water samples is needed for broad and sensitive detection of toxic industrial chemicals, or TICs. The use of unicellular organisms in cell-based detection systems is particularly advantageous both because these organisms have developed a natural ability to respond to environmental… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project proposes to develop a noninvasive intracranial pressure (ICP) monitor based on a pilot clinical study correlating ocular blood pressure and blood flow parameters to ICP. The proposed novel device will combine several standard medical… more
Abstract:DESCRIPTION (provided by applicant): Significance: Almost 30% of U.S. adults have pre-diabetes. Without weight loss and changes in physical activity and diet, more than 50% of them will eventually develop type 2 diabetes (T2DM), with its increased risk ofcardiovascular disease and many other… more
Abstract:DESCRIPTION (provided by applicant): ClotFoam(R) , is a novel adhesive sealant composition and second-generation hemostatic agent. This biological agent was designed to arrest moderate to severe blood loss arising from intracavitary traumatic injury orintraoperative hemorrhage without compression… more
Abstract:DESCRIPTION (provided by applicant): This SBIR project is a collaborative effort between AC Diagnostics, Inc. and the University of Pennsylvania to develop and demonstrate a novel diagnostic system for automated on-site detection of viral pathogens in biomedical laboratory animals. Microbial… more
Abstract:DESCRIPTION (provided by applicant): Missing data and measurement errors are common problems in statistical data analysis. We are interested in experimental and observational studies where there exist missing data and measurement errors problems. Examplesinclude health surveys containing… more
Abstract:This Small Business Innovation Research (SBIR) Phase II project seeks to further quantify the mechanical performance of mycological bio-composites that address the automotive and structural core industries, while concurrently scaling and demonstrating material production. The engineered composites… more
Abstract:This Small Business Innovation Research (SBIR) Phase II project will enable Energetiq Technology, Inc. to develop and commercialize an advanced Open-Path FTIR Spectrometer (OPFTIR) instrument for monitoring of atmospheric gases over extended distances. The Phase II technical goals will be the… more
Abstract:ABSTRACT: We propose to develop a tunable, versatile high-efficiency, optical free-space link including the transmitter and receiver with an adaptive modulation capability. The development of adaptive modulation will be achieved through the study of contrasting approaches for adaptive modulation… more
Abstract:ABSTRACT: Next generation defense and commercial satellites will acquire and process data at significantly higher rates than current satellites. This will necessitate the development of high speed fiber optic communications infrastructure for intra-satellite communications, including the… more
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