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Agency:HHS
Phase:Phase I
Program:SBIR
Company: ANIMOTION, INC. Agency/Program/Year/Phase: HHS / SBIR / 2010 / 1
Abstract: DESCRIPTION (provided by applicant): Loss of ambulatory function due to disease and injury has an increasing societal impact as the US population ages and has an even greater impact on veterans. The development of methods for effective assessment and reha
bilitation of impairments of the ambulatory… more
Company: CONTEXTUAL CHANGE, LLC Agency/Program/Year/Phase: HHS / SBIR / 2010 / 1
Abstract: DESCRIPTION (provided by applicant): There is a strong need for the development and dissemination of effective prevention programs for mental health problems with college students, who are at risk for depression, anxiety, eating disorders, substance use, a
nd many other difficulties (American… more
Company: CONTEXTUAL CHANGE, LLC Agency/Program/Year/Phase: HHS / SBIR / 2011 / 1
Abstract: DESCRIPTION (provided by applicant): Nearly half of all college students have a diagnosable mental health problem (Blanco et al., 2008). College counseling centers (CCCs) are faced with increasing demands for services from Universities, students and parents to meet the treatment needs of their… more
Company: CATABASIS PHARMACEUTICALS, INC. Agency/Program/Year/Phase: HHS / SBIR / 2010 / 1
Abstract: DESCRIPTION (provided by applicant): 5-Aminosalicylic acid (5-ASA) and its analogs such as the prodrug sulfasalazine are front line therapy for Inflammatory Bowel Disease (IBD), which include both Crohn's disease and ulcerative colitis. 5-ASA is only moder
ately efficacious in putting patients into… more
Company: CRINETICS PHARMACEUTICALS, INC. Agency/Program/Year/Phase: HHS / SBIR / 2010 / 1
Abstract: DESCRIPTION (provided by applicant): Measurements of the affinity, potency and efficacy of ligands to G protein-coupled receptors (GPCRs) are fundamental to pharmacology and drug discovery. Cellular functional assays measuring the production of GPCR second
messengers such as cAMP and inositol… more
Company: CRINETICS PHARMACEUTICALS, INC. Agency/Program/Year/Phase: HHS / SBIR / 2011 / 1
Abstract: DESCRIPTION (provided by applicant): Analogs of the neuropeptide somatostatin are important therapeutics for the treatment of hormone secreting tumors with annual sales in excess of 1.3B. However, currently available peptide depots are only effective in approximately half the patients with growth… more
Company: CRINETICS PHARMACEUTICALS, INC. Agency/Program/Year/Phase: HHS / SBIR / 2012 / 1
Abstract: DESCRIPTION (provided by applicant): During the past decade, the discovery of kisspeptin peptides and their cognate receptor KISS1R (aka GPR54) has expanded our mechanistic understanding of the hypthothalamic-pituitary-gonadal (HPG) axis. The kisspeptin system has been shown to be an integrator of… more
Company: RADIX THERAPEUTICS, LLC Agency/Program/Year/Phase: HHS / SBIR / 2010 / 1
Abstract: DESCRIPTION (provided by applicant): With increasing risk of nuclear detonation there is a need for effective medicinal counter-measures that can be delivered after exposure to prevent radiation-induced mortality. Adding to this need, mortality increases s
ignificantly when radiation is combined… more
Company: RADIX THERAPEUTICS, LLC Agency/Program/Year/Phase: HHS / SBIR / 2011 / 1
Abstract: Over 60% of cancer patients are treated with radiotherapy, yet radiation-induced normal tissue damage can cause organ dysfunction and morbidity. Radiotherapy of CNS tumors is problematic due to potential for diminished neurological function or mental retardation. Our proprietary thrombin-derived… more
Company: BEACON BIOTECHNOLOGY, LLC Agency/Program/Year/Phase: HHS / SBIR / 2010 / 1
Abstract: * * Description of team not provided in the application aside from CVs thus making it difficult to assess quality. 3. Innovation: Strengths * Development of inexpensive, simple, disposable, point-of-care screening method attractive. * A
ntigen-modified detector is unique. *… more
Company: CARE TEAM SOLUTIONS, LLC Agency/Program/Year/Phase: HHS / SBIR / 2010 / 1
Abstract: DESCRIPTION (provided by applicant): For such life-changing impact that bariatric surgery represents for obesity, this popular procedure is noted for its poor post- operative follow-up rates and outcomes tracking. Laparoscopic Gastric Bypass (LGB) has emer
ged as one of the most popular surgical… more
Company: ACCELALOX, INC. Agency/Program/Year/Phase: HHS / SBIR / 2010 / 1
Abstract: DESCRIPTION (provided by applicant): Bone fractures are common traumatic injuries that often cause temporary disability. In healthy children and adults, fractures normally heal without sequelae, though the temporary disability can lead to muscle atrophy,
rehabilitation, and lost time from the work… more
Company: SOLOHEALTH, INC. Agency/Program/Year/Phase: HHS / SBIR / 2010 / 1
Abstract: DESCRIPTION (provided by applicant): This Fast-Track SBIR proposal submitted by SoloHealth of Duluth, Georgia, requests grant funds to build and test a multifunction health-screening kiosk. Our current kiosk prototype, EyeSite, has demonstrated efficacy in
reaching low income, high health disparity… more
Company: ORCHARD KINETICS, LLC Agency/Program/Year/Phase: HHS / SBIR / 2010 / 1
Abstract: DESCRIPTION (provided by applicant): High-fidelity clinical movement analysis with body mounted sensors Summary Clinical movement analysis is an important tool for management of orthopedic and neurological movement disorders. Despite scientific and clinic
al successes, this tool has not found… more
Company: ABC FOR HEALTH, INC. Agency/Program/Year/Phase: HHS / SBIR / 2010 / 1
Abstract: DESCRIPTION (provided by applicant): Reducing Health Disparities: A Health IT Solution, proposes a collaborative effort to coordinate community stakeholders in Dane County, WI, to integrate a replicable and innovative health IT solution to overcome syste
mic barriers that exacerbate health… more
Company: Limaging, LLC Agency/Program/Year/Phase: HHS / SBIR / 2011 / 1
Abstract: DESCRIPTION (provided by applicant): For this SBIR Limaging, LLC teams with researchers in Ophthalmology at the Wilmer Eye Institute at Johns Hopkins University to develop DBillScan, a camera phone based currency reader to identify U.S. dollar bills for the blind and visual impaired (VI). In many… more
Company: MUREX PHARMA Agency/Program/Year/Phase: HHS / SBIR / 2010 / 1
Abstract: The three basic requirements for an effective RNA interference-based therapy are 1) identification of key genetic defect[s] that provide pivotal survival advantage(s) to the overall cancer cell population; 2) construction of a potent and durable target-specific therapeutic agent; and 3)… more
Company: KeraNetics, LLC Agency/Program/Year/Phase: HHS / SBIR / 2010 / 1
Abstract: DESCRIPTION (provided by applicant): This is a proposal to develop a keratin based resuscitation fluid that greatly improves outcomes for patients following treatment of hemorrhage. Inadequate fluid resuscitation technology has contributed to tens of thous
ands of lives lost and billions of dollars… more
Company: BLACKROCK MICROSYSTEMS Agency/Program/Year/Phase: HHS / SBIR / 2010 / 1
Abstract: DESCRIPTION (provided by applicant): This project addresses the process development and evaluation of an extremely flexible, Parylene C, micro-ribbon cable that is both biocompatible and biostable. Such a cable would be employed to link micro-electrode arr
ays with percutaneous connectors as well as… more
Company: BLACKROCK MICROSYSTEMS Agency/Program/Year/Phase: HHS / SBIR / 2011 / 1
Abstract: DESCRIPTION (provided by applicant): The array technology developed by Normann et.al. two decades ago at the University of Utah is currently being manufactured and marketed to the neuroscience research community by Blackrock Microsystems (formerly known asCyberkinetics, Inc., CKI). The Utah… more
Company: Masstech, Inc. Agency/Program/Year/Phase: HHS / SBIR / 2010 / 1
Abstract: DESCRIPTION (provided by applicant): The primary goal of this proposal is to develop a novel fragmentation technique based on interaction of peptide ions with radical beam. We plan to demonstrate that this technique will produce different type of fragment
ions compared to those obtained in… more
Company: Masstech, Inc. Agency/Program/Year/Phase: HHS / SBIR / 2011 / 1
Abstract: DESCRIPTION (provided by applicant): The primary objective of this proposal is to develop a novel ion source for the efficient on-line coupling of a wide array of chromatographic techniques with mass spectrometry. The use of liquid chromatography separation is a prerequisite for high-throughput mass… more
Company: Masstech, Inc. Agency/Program/Year/Phase: HHS / SBIR / 2012 / 1
Abstract: DESCRIPTION (provided by applicant): Significant increase in the efficiency and speed of electron transfer dissociation (ETD) in tandem mass spectrometry (MS) will have a profound impact on its applications to the entire analytical field of characterization of posttranslational modifications (PTM)… more
Company: Masstech, Inc. Agency/Program/Year/Phase: HHS / SBIR / 2012 / 1
Abstract: DESCRIPTION (provided by applicant): Increasing efficiency of ion detection in Fourier Transform Mass Spectrometry (FTMS) can have a tremendous impact on its applications in proteomics and entire analytical field. At present, the sensitivity of FTMS instruments is limited by electrical noise of… more
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