Abstract:DESCRIPTION (provided by applicant): The application's broad, long-term objectives are to develop a rapid, high-throughput clinical assay for 3' fibrinogen that will be used to assess the risk of a patient developing venous thromboembolism. This assay will
guide clinical management, particularly… more
Abstract:DESCRIPTION (provided by applicant): Chronic obstructive pulmonary disease (COPD) is one of the leading causes of morbidity and mortality worldwide. The currently available treatments are largely palliative and have minimal impact on the inflammatory proce
ss in COPD that inexorably leads to a… more
Abstract:DESCRIPTION (provided by applicant): Despite notable achievements over the past two decades, cancer remains a challenging 21st century epidemic demanding new, more effective drugs. Nitric oxide (NO) is well known to kill cancer cells without harming norma
l bone marrow cells, but until now has not… more
Abstract:DESCRIPTION (provided by applicant): Ohmx Corporation is developing integrated point-of-care (POC) bioelectronic sensor technologies for protein biomarkers relevant to cancer diagnosis and risk stratification. The principal goal of this SBIR proposal is to
develop an assay for prostate-specific… more
Abstract:DESCRIPTION (provided by applicant): Loss of ambulatory function due to disease and injury has an increasing societal impact as the US population ages and has an even greater impact on veterans. The development of methods for effective assessment and reha
bilitation of impairments of the ambulatory… more
Abstract:DESCRIPTION (provided by applicant): There is a strong need for the development and dissemination of effective prevention programs for mental health problems with college students, who are at risk for depression, anxiety, eating disorders, substance use, a
nd many other difficulties (American… more
Abstract:DESCRIPTION (provided by applicant): Nearly half of all college students have a diagnosable mental health problem (Blanco et al., 2008). College counseling centers (CCCs) are faced with increasing demands for services from Universities, students and parents to meet the treatment needs of their… more
Abstract:DESCRIPTION (provided by applicant): 5-Aminosalicylic acid (5-ASA) and its analogs such as the prodrug sulfasalazine are front line therapy for Inflammatory Bowel Disease (IBD), which include both Crohn's disease and ulcerative colitis. 5-ASA is only moder
ately efficacious in putting patients into… more
Abstract:DESCRIPTION (provided by applicant): Measurements of the affinity, potency and efficacy of ligands to G protein-coupled receptors (GPCRs) are fundamental to pharmacology and drug discovery. Cellular functional assays measuring the production of GPCR second
messengers such as cAMP and inositol… more
Abstract:DESCRIPTION (provided by applicant): Analogs of the neuropeptide somatostatin are important therapeutics for the treatment of hormone secreting tumors with annual sales in excess of 1.3B. However, currently available peptide depots are only effective in approximately half the patients with growth… more
Abstract:DESCRIPTION (provided by applicant): During the past decade, the discovery of kisspeptin peptides and their cognate receptor KISS1R (aka GPR54) has expanded our mechanistic understanding of the hypthothalamic-pituitary-gonadal (HPG) axis. The kisspeptin system has been shown to be an integrator of… more
Abstract:DESCRIPTION (provided by applicant): With increasing risk of nuclear detonation there is a need for effective medicinal counter-measures that can be delivered after exposure to prevent radiation-induced mortality. Adding to this need, mortality increases s
ignificantly when radiation is combined… more
Abstract:Over 60% of cancer patients are treated with radiotherapy, yet radiation-induced normal tissue damage can cause organ dysfunction and morbidity. Radiotherapy of CNS tumors is problematic due to potential for diminished neurological function or mental retardation. Our proprietary thrombin-derived… more
Abstract:* * Description of team not provided in the application aside from CVs thus making it difficult to assess quality. 3. Innovation: Strengths * Development of inexpensive, simple, disposable, point-of-care screening method attractive. * A
ntigen-modified detector is unique. *… more
Abstract:DESCRIPTION (provided by applicant): For such life-changing impact that bariatric surgery represents for obesity, this popular procedure is noted for its poor post- operative follow-up rates and outcomes tracking. Laparoscopic Gastric Bypass (LGB) has emer
ged as one of the most popular surgical… more
Abstract:ABSTRACT Technological aids supporting medication management for chronically ill patients are proliferating, offered in electronic telehealth devices. Pill organizers, reminders, monitors, and usage communicators have enabled an array of home health aids to support users and caregivers in pill… more
Abstract:Opiate-agonist pharmacotherapy utilizing buprenorphine/naloxone is known to decrease illicit opiate use. However, poor medication management and misuse during self-managed opioid substitution therapy (OST) constrains efficacy, while aggrandizing relapse,hospitalizations and mortality. One of the… more
Abstract:DESCRIPTION (provided by applicant): Bone fractures are common traumatic injuries that often cause temporary disability. In healthy children and adults, fractures normally heal without sequelae, though the temporary disability can lead to muscle atrophy,
rehabilitation, and lost time from the work… more
Abstract:DESCRIPTION (provided by applicant): This Fast-Track SBIR proposal submitted by SoloHealth of Duluth, Georgia, requests grant funds to build and test a multifunction health-screening kiosk. Our current kiosk prototype, EyeSite, has demonstrated efficacy in
reaching low income, high health disparity… more
Abstract:DESCRIPTION (provided by applicant): High-fidelity clinical movement analysis with body mounted sensors Summary Clinical movement analysis is an important tool for management of orthopedic and neurological movement disorders. Despite scientific and clinic
al successes, this tool has not found… more
Abstract:DESCRIPTION (provided by applicant): Reducing Health Disparities: A Health IT Solution, proposes a collaborative effort to coordinate community stakeholders in Dane County, WI, to integrate a replicable and innovative health IT solution to overcome syste
mic barriers that exacerbate health… more
Abstract:DESCRIPTION (provided by applicant): For this SBIR Limaging, LLC teams with researchers in Ophthalmology at the Wilmer Eye Institute at Johns Hopkins University to develop DBillScan, a camera phone based currency reader to identify U.S. dollar bills for the blind and visual impaired (VI). In many… more
Abstract:The three basic requirements for an effective RNA interference-based therapy are 1) identification of key genetic defect[s] that provide pivotal survival advantage(s) to the overall cancer cell population; 2) construction of a potent and durable target-specific therapeutic agent; and 3)… more
Abstract:DESCRIPTION (provided by applicant): This is a proposal to develop a keratin based resuscitation fluid that greatly improves outcomes for patients following treatment of hemorrhage. Inadequate fluid resuscitation technology has contributed to tens of thous
ands of lives lost and billions of dollars… more
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