Abstract:DESCRIPTION (provided by applicant): Current LoCs are assay-specific and are custom-built for each single experiment. Performing an experiment requires life scientists to endure the time-consuming process of designing, fabricating, and testing a chip befor
e conducting the actual experiment. This… more
Abstract:DESCRIPTION (provided by applicant): Sickle cell disease (SCD) is a hereditary blood disorder, affecting over 75,000 people in the United States and millions of people worldwide. In the US, those with SCD have an average mortality in their 40s, a poor qual
ity of life and high medical costs. In SCD,… more
Abstract:DESCRIPTION (provided by applicant): In this phase I, Koronis Biomedical Technology Corporation (KBT) proposes to develop and evaluate a prototype device that provides non-invasive, real-time intracranial pressure (ICP) monitoring. The proposed device will
measure ICP with the simplicity of a… more
Abstract:DESCRIPTION (provided by applicant): Koronis Biomedical Technologies (KBT) proposes to develop a wireless implantable dosimeter with the ability to track both location and orientation in real-time by combining radiation sensitive field- effect-device (RADF
ET) technology together with… more
Abstract:DESCRIPTION (provided by applicant): Koronis Biomedical Technology Corporation (KBT) proposes to develop an indoor wayfinding device utilizing a novel indoor location technology based on magnetic anomaly detection, and augmented with inertial dead-reckonin
g technology. Unique magnetic anomaly… more
Abstract:DESCRIPTION (provided by applicant): The objective is to use a new innovative sensor technology called a Doppler velocimeter (DV) for solving the problem of wayfinding indoors for the vision impaired. By performing a Doppler measurement of the floor movement relative to the walking person it is… more
Abstract:DESCRIPTION (provided by applicant): Koronis Biomedical Technologies Corporation (KBT) proposes to develop a spirometer device targeted toward the needs of lung transplantation patients. Spirometers are standard care for the management of post-operative lung transplantation patients due to their… more
Abstract:DESCRIPTION (provided by applicant): Koronis Biomedical Technology Corporation (KBT) proposes to develop and evaluate a miniature ultralow power pulse oximeter for long-term wearable monitoring. There continues to be a clinical need for an unobtrusive pulse oximeter sensor that is small and can be… more
Abstract:DESCRIPTION (provided by applicant): Sudden cardiac death (SCD) results in approximately 450,000 deaths each year in the United States alone of older adults. Most fatal SCD events are caused by ventricular arrhythmias (ventricular tachycardia and ventricular fibrillation) in patients both with and… more
Abstract:DESCRIPTION (provided by applicant): Koronis Biomedical Technologies (KBT) proposes to develop a hearing aid with the ability to replay a recent period of audio. The hearing aid will be equipped with an additional memory to temporarily store the recently recorded audio and will have buttons to… more
Abstract:DESCRIPTION (provided by applicant): In this Phase I research Koronis Biomedical Technologies Corporation (KBT) will construct a system to improve mobility and transportation access for the cognitively impaired. The proposed system is intended to allow thecognitively impaired to use public… more
Abstract:DESCRIPTION (provided by applicant): Koronis Biomedical Technologies Corporation (KBT) proposes to develop a spirometer device targeted toward home-based monitoring of asthma patients. Spirometry has well established advantages over peak flow meters for the monitoring of pulmonary function in asthma… more
Abstract:DESCRIPTION (provided by applicant): Clinical diagnostic laboratories determine the presence, or absence, of viruses, parasites, bacteria, or fungi in biological specimens submitted under physicians' order for testing. The medical field has estimated that
over 70% of all health care decisions are… more
Abstract:DESCRIPTION (provided by applicant): Chronic total occlusions (CTOs), defined as vessels that have been completely occluded for 3 months, are a prevalent vascular disease found in about one-third of patients undergoing a coronary angiogram and in 30-50% of
peripheral procedures. Revascularization… more
Abstract:DESCRIPTION (provided by applicant): With the increasing requirements for assuming prominent disease management and preventive screening activities, primary care physicians find themselves lacking cost-effective resources to improve the quality of medical
care they provide to patients with chronic… more
Abstract:DESCRIPTION (provided by applicant): The goal of the Enhanced Medication Management Program (eMMp) being developed by MedMinder Systems, Inc. is to increase the ability of frail elders to adhere to complex medication regimens for chronic conditions. Ad
herence will facilitate effective self-care… more
Abstract:DESCRIPTION (provided by applicant): This proposal addresses PHS 2009-02 Omnibus Solicitation of the NIH, CDC, FDA and ACF for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44]). Hypertrophic scars commonly form during healing of
deep dermal wounds and are characterized… more
Abstract:DESCRIPTION (provided by applicant): The long-term goal of this project is to create an efficient, unique, and versatile laser instrument that will have applications in a large range of surgical procedures including dermatology, laryngology, otology, and o
phthalmology. In the near-term, these… more
Abstract:DESCRIPTION (provided by applicant): Innovative products that reduce the costs and increase the quality and productivity of drug discovery research are more important than ever. We will rigorously validate prototypes of compound management products that wi
ll help overcome limitations in the field… more
Abstract:DESCRIPTION (provided by applicant): The overall goal of this work is to produce a wearable continuous alcohol monitor that is pain- free and noninvasive, with wireless communications capability to enable remote monitoring. The monitor centers around a nov
el biosensor consisting of a multi-well… more
Abstract:DESCRIPTION (provided by applicant): Vitamin D plays a critical role in calcium metabolism and bone health in children and adults. It is now recognized that every tissue and cell in the body have a vitamin D receptor and thus every tissue and cell in the b
ody is a target for vitamin D action.… more
Abstract:DESCRIPTION (provided by applicant): Carbonix LLC proposes a Phase I research program on its novel process that abates indoor allergenic proteins that are implicated in allergies and asthma attacks. Common allergenic proteins are produced, for example, by
household dust mites and cats. It is… more
Abstract:DESCRIPTION (provided by applicant): Allergens and Induced Asthma: Eradicating Indoor Allergens and Dust Mites The mission of CarboNix LLC is the clinically effective abatement of common indoor allergens that cause allergic reactions and frequently induceasthma, especially in children. The focus of… more
Abstract:DESCRIPTION (provided by applicant): To meet the Agency's requirement for rapid, precise and on-site measurement of emerging contaminants such as fire retardant chemical PBDEs, critical technologies must be developed where upon mixing a reagent and a detec
tion target, a signal is generated without… more
Abstract:DESCRIPTION (provided by applicant): To meet Agency requirement for reliable assessment of botulinum neuron toxin A (BoNT/A) in manufactured products, we propose to apply the fluorescent peptide beacon technology for measurement of both binding function and proteolytic function of the toxin in a… more
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