Abstract:DESCRIPTION (provided by applicant): The incidence of pancreatic adenocarcinoma (PDA) is gt 45,000 cases per year in the US and is increasing. While new chemotherapy regimens such as Abraxane and FOLFIRINOX extend overall survival, none offer the promise of long-term disease-free survival. We submit… more
Abstract:? DESCRIPTION (provided by applicant): Manual drug compounding of chemotherapy medications permits deadly dosing errors and toxic drug exposure and therefore poses unnecessary risks to patients and healthcare professionals. Some robotic compounding devices have been developed in response;… more
Abstract:DESCRIPTION (provided by applicant): The primary objective of the current project is to develop and evaluate the efficacy of on-line brain plasticity-based computerized assessment tool and training program for the prevention and delay of the onset of Alzheimer's disease (AD). This novel… more
Abstract:DESCRIPTION (provided by applicant): The goal of the current project is to revise a prototype of a computerized attention training program (Memory Lane-Amplified Attention Training, M-AAT) designed for age-related cognitive decline completed in Phase I, and conduct a multi-site, randomized,… more
Abstract:DESCRIPTION (provided by applicant): The goal of the current project is to revise a prototype of a computerized, web-deliverable, social cognition training program (SocialVille) for schizophrenia completed in Phase I, and conduct a multi-site, randomized,controlled trial to establish efficacy in… more
Abstract:DESCRIPTION (provided by applicant): Sarcopenia, or the deterioration of muscle health with advancing age, is a major public health concern in the developed world. Some of the most important factors underlying the development of sarcopenia are age- relatedchange in muscle composition, including the… more
Abstract:DESCRIPTION (provided by applicant): The neuromuscular assessment of children is uniquely challenging. Unlike examination of the heart or lung, the complete bedside assessment of the neuromuscular system requires the active participation of the child and results must be evaluated in the context of… more
Abstract:DESCRIPTION (provided by applicant): Individuals with intellectual disabilities (ID) are at higher risk for abuse than the general population. Increasing numbers of people with ID are living independently in the community with both its benefits and its risks. Many individuals with ID are subjected… more
Abstract:Use of high-concentrate diets in cattle production is a common practice in the United States to maximize production efficiency, enhance meat quality, and minimize meat and milk cost of production. Transition from high-fiber to high-concentrate diets is challenging and put the animals at risk for… more
Abstract:ABSTRACT: Recent demand for broadband satellite communications (SATCOM) has risen sharply for both the defense and commercial sectors. Tactical SATCOM, such as WGS, AEHF, and GBS, require increasingly high capacity to support DoD's C4ISR requirements, while on the other hand, civilian… more
Abstract:The long-term objective of this project is to develop an ultrasound contrast agent for detecting and characterizing vulnerable plaque. Vulnerable plaque is responsible for myocardial infarction and stroke. Early detection of vulnerable plaque would enableintervention to be performed before heart… more
Abstract:DESCRIPTION (provided by applicant): Glioblastoma multiforme (GBM) is a highly aggressive, malignant brain tumor widely known to be hypoxic and hypoxia is an important factor in the poor response of GBM to treatment. The most common therapy for GBM is surgical excision followed by fractionated RT +… more
Abstract:DESCRIPTION (provided by applicant): Ovarian cancer is a highly lethal gynecologic cancer with an estimated 21,860 new cases and approximately 13,850 deaths in the USA per year. A large majority of the patients, cancer reoccurs after initial treatment and manifest resistance to conventional and… more
Abstract:ABSTRACT: Solar arrays play a key role in the operation of spacecrafts and unmanned aerial vehicles. Traditionally, inorganic semiconductor based solar arrays have been used for space applications because of their highest efficiencies. However, these solar arrays have several major limitations like… more
Abstract:Worldwide there are a number of synchrotron beamlines dedicated to resonant soft x-ray inelastic scattering. There are also new beamlines currently being designed to take advantage of improved third generation synchrotron radiation sources and this powerful experimental technique for probing… more
Abstract:The effectiveness of synchrotron radiation science is being hindered by the limited availability of advanced detectors. This is due to the limited deployment of existing detectors as well as limited development effort to provide new advanced capabilities. As synchrotron radiation experiments become… more
Abstract:Unlike raw wood pellets, energy dense torrefied biomass pellets or briquettes share important traits with coal which make them a promising alternative clean fuel to use directly in coal plants. They are brittle (not fibrous, like raw pellets), so they can be pulverized just like coal before being… more
Abstract:The Department of Energy and other federal agencies have made significant investments in software performance engineering tools, which can be complex and difficult to use. Novice users first encountering a tools complexity and vast array of features are intimidated and easily frustrated. There is… more
Abstract:Numerical simulations of chemical kinetics are a critical component of aerospace research, Earth systems research, and energy research. These simulations enable a better understanding of the evolution of chemical species over time in domains as diverse as climate and weather prediction, combustion… more
Abstract:The use of advanced ceramic materials, such as silicon carbide, for light water reactor fuel cladding is being investigated, in part due to the increased safety margin afforded by this technology over conventional zircaloy metallic claddings. In light of the Fukushima events, safety concerns have… more
Abstract:525 Solutions will manufacture highly economical and biodegradable uranium-from-seawater sorbents from fishing industry waste, and provide them to government-designated mining companies, at the same time leveraging the governmental funds to create a sustainable chitin products business, enabling… more
Abstract:Brayton Energy is a developer of turbomachinery systems, specializing in gas turbines, turbojets, turbochargers, and turbo-compounding equipment. In the proposed program, Brayton will design and bench-test the critical elements of novel single-shaft turbocharger with integral motor/alternator… more
Abstract:Molten salt heat transfer fluid a desirable upgrade to solar plant designs because of its superior temperature, thermal, and pumping properties compared to steam or heat transfer oil. It is non- hazardous to the environment, not flammable, and easy to transport and clean up. It is advantageous for… more
Abstract:At NOVATIO Engineering, our solution to this problem is practical, novel, proven at a smaller scale and now demonstrated at the 3 kW size range: conversion of a commercial lightweight gasoline generator to operate with diesel fuel or JP-8 in spark ignition mode. Prior to this Phase I SBIR effort,… more
Abstract:A development program is proposed for a design automation software package that enables the generation of complex surfaces, with user defined or automated definition of point charge and hydrophobic/hydrophilic properties, using DNA origami as a presentation substrate. Building upon Parabon"s… more
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