Abstract:This Small Business Innovation Research (SBIR) Phase I project is about developing an Educational Interactive Hemodynamics Flow Visualization and Analysis System to be used in physiology courses for anyone studying blood flows such as medical or bioengineering students. Study of hemodynamics is very… more
Abstract:The incorporation of viscous analysis in design is vital for a completeunderstanding of aerodynamic problems.This proposal offers to develop and integrate with RotCFD a method for semi-automatically generating grids suitable for viscous
analysis on complex configurations as well as parallelize the… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project aims to use nitrocarburizing plasmas to generate nanostructured layer on top of nitride case on cast iron surfaces of cast iron dies used in the stamping of high-strength-steel sheets. To deposit nanostructured coatings, reactive… more
Abstract:DESCRIPTION (provided by applicant): In approximately 30% of epileptic patients, seizures are not controlled by currently available therapeutic agents. Even though a number of new chemical entities have entered the marketplace, therapy resistant seizures remain. This project is innovative in that… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project will test the baseline requirements necessary for the development of an employee performance measurement platform that utilizes technology to accomplish a continuous service performance data flow used to motivate employees to higher… more
Abstract:The Smart Grid opens the door to the development of many companion devices which will in turn enable the development of a variety of devices for household electricity-consuming appliances that can communicate with it; especially, many major appliance manufacturers (such as Whirlpool and General… more
Abstract:DESCRIPTION (provided by applicant): Drugs used for cancer chemotherapy tend to be highly cytotoxic and genotoxic, with well-documented carcinogenic, mutagenic, and teratogenic effects. Long-term, occupational exposure to these highly toxic drugs presents
serious health risks to the healthcare… more
Abstract:This SBIR Phase I project will develop the feasibility of using piezoelectric transducers to create an artificial plant, embodied as tall bunchgrass, that will harvest and store energy from wind. This device will have aesthetic appeal and provide a nonpolluting supplement to energy produced by wind… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project aims to demonstrate a unique and affordable method to nanotexture the surfaces of metal platform drug-eluting stents (DES) using ultrafast laser surface modification. This technology is relatively inexpensive and capable of integrating… more
Abstract:This proposal describes an approach to realize InAs/GaSb type II superlattice focal plane arrays through planar processing. A problem with conventional mesa diode processing approaches is that nonradiative surface recombination at the exposed pn junction is extremely rapid, leading to surface… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project will develop a compact, widely-tunable, high-brightness laser diode spectrometer that will be the core of an automated point-of-care (POC) monitor capable of tracking key blood metabolites for patients in intensive care units. The… more
Abstract:DESCRIPTION (provided by applicant): Indigenous population, travelers and troops present in Africa and South America are clearly at risk of exposure to several arenaviruses. Several human pathogenic arenaviruses, e.g., Lassa and Junin viruses, are listed o
n the NIAID's Priority Pathogens and CDC's… more
Abstract:DESCRIPTION (provided by applicant): Atherosclerosis is the primary cause of cardiovascular disease, which is the most common cause of death in the United States. Atherosclerosis is characterized by the accumulation of lipids, cholesterol, calcium deposi
ts, and cellular debris in vessel walls,… more
Abstract:WSSV is the most serious disease in farmed marine shrimp causing considerable financial losses throughout the last decade across the globe. It infects a wide variety of crustacean hosts including numerous species of wild and cultured marine shrimp, crayfish, and prawns. Although a multitude of… more
Abstract:DESCRIPTION (provided by applicant): Sarcopenia, defined as age related loss of muscle mass and muscle function and strength, is very prevalent among the elderly. Sarcopenia is one of the largest public health problems facing a rapidly increasing, aging po
pulation in the United States and leads to… more
Abstract:DESCRIPTION (provided by applicant): According to the American Cancer Society an estimated 182,000 cases of invasive breast cancer occurred in the US in 2008, with 40,000 deaths due to breast cancer. Among women with metastatic breast cancer, the 5-year su
rvival rate is 27%. The studies proposed in… more
Abstract:DESCRIPTION (provided by applicant): If left undetected and untreated, reduced vision in one eye can lead to monocular blindness in an amblyopic eye. Most vision screening is conducted on children once they have started kindergarten; this is after the crit
ical detection period for the treatment of… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project will develop sensing technology capable of continuously monitoring concentrations of critical metabolites during protein expression with the yeast Pichia pastoris. Presently, continuous monitoring is unavailable and this process is… more
Abstract:DESCRIPTION (provided by applicant): In contrast to the conventional wisdom that the interior problem does not have a unique solution, in 2007 we developed and patented the interior tomography technology (exact and stable interior reconstruction from x-ray
projection data associated with only lines… more
Abstract:DESCRIPTION (provided by applicant): The goal of these studies is the development of a treatment for hormone refractory prostate cancer based on the inhibition of an enzyme geranygeranyl disphosphate synthase (GGDPS). We have developed a group of proprieta
ry bisphosphonates containing isoprene… more
Abstract:This Small Business Innovation Research Phase I project is for the development of technology to crystallize proteins using less sample and with higher speed and success than current high throughput protein crystallization methods. Protein crystallization is an intermediate step in determining the… more
Abstract:The objective of this study is to demonstrate the efficacy and broad applicability of the human immune-modulating alphaGal Adjuvant Technology for antiviral vaccine development. We will use viral vaccine candidates for the select Category A viral pathogens Zaire ebolavirus (ZEBOV, filovirus), Rift… more
Abstract:Determining meat quality attributes in food animals is essential for genetic selection, sorting, and marketing. Ultrasound techniques have the potential to benefit the swine industry for improvements in both quality and yield measures by non-destructive means. There is a need to continually improve… more
Abstract:DESCRIPTION (provided by applicant): Cystic fibrosis (CF) is caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. The CFTR gene encodes a chloride channel that regulates ion flow across epithelial cell membranes. Most
CF patients have a mutation that deletes… more
Abstract:This Small Business Innovation Research Phase 1 project develops a technology by which diesel fuel consumption can be significantly reduced while increasing productivity in recovering woody biomass. Diesel fuel is the number one operating cost of an industrial grinder and it is estimated that the… more
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