Abstract:DESCRIPTION (provided by applicant): Dysfunction of G protein-coupled receptors (GPCRs) results in diseases as diverse as Alzheimer's, Parkinson's, diabetes, dwarfism, color blindness, retina pigmentosa and asthma. GPCRs are also involved in depression, sc
hizophrenia, sleeplessness, hypertension,… more
Abstract:The objective of our Phase II work is to develop and demonstrate the Magnetic Underwater Mine (MAGNUM) confirmation sensor and associated integrated UUV sensor module. In the Phase I project, Sky Research and Geometrics explored the use of Micro-Fabricated Atomic Magnetometers (MFAM) technology to… more
Abstract:DESCRIPTION (provided by applicant): The proposed project builds upon Phase I proof of concept efforts wherein the basic foundational components of an Internet-based Treatment Fidelity Monitoring System, the ITFMS, were created to assist MTFC consultantsand implementing agencies to improve… more
Abstract:DESCRIPTION (provided by applicant): Flow cytometry is used to rapidly gather large quantities of data on cell type and function. The manual process of classifying hundreds of thousands of cells forms a bottleneck in diagnostics, high-throughput screening,
clinical trials, and large-scale research… more
Abstract:Recovery of water from brine is critically important for future manned space exploration. Resupply of water is prohibitively costly for such extended missions. Water reclamation processes typically recover 90-95% of the water present in wastewater formed by combining urine, hygiene water, and… more
Abstract:A back-illuminated planar InGaAs photodiode tested to have 95% quantum effiiency (QE) at 1550 nm, area greater than 1 mm2, low capacitance (<23 pF), and high bandwidth (>125 MHz) will be improved. Although the existing Phase I device exhibited bulk material dark current generation better… more
Abstract:Visible-transparent upconverting films consisting of lanthanide-doped metal-oxide nanocrystal (NC) quantum dots functionalized with near-infrared (NIR) and short-wavelength infrared (SWIR) sensitizers will be optimized for integration with polycarbonate optical elements. In Phase I, upconversion was… more
Abstract:A 128 x 128-format avalanche photodiode (APD) focal plane array (FPA), including a low-power dual-mode readout integrated circuit (ROIC) and low excess noise, high gain (M>1,200) will be developed for laser radar (LADAR) applications requiring reduced SWAP. The FPA gives LADAR seekers an advanced… more
Abstract:Current methods of growing carbon nanotubes (CNTs) of specific chirality yield mixtures of single-walled CNTs (SWNTs) with different structures and electronic properties, and methods to separate nanotubes by their electronic properties remain expensive and small-scale. Accordingly, synthesis today… more
Abstract:90087S09-II Expanding user demand for X-ray beamline time for science experiments in diverse fields necessitates expensive new beamlines, or the more efficient use of existing resources. Detectors that collect more data, with efficient on-chip and off-chip processing of the resulting data streams,… more
Abstract:Nighttime bioluminescence poses a large naval tactical problem. Therefore a navigation aid is required for underwater vehicles (manned or un-manned) that will sense the platform-induced (e.g. an Unmanned Underwater Vehicle, SEAL Delivery Vehicle, or diver) bioluminescence, water optical properties,… more
Abstract:DESCRIPTION (provided by applicant): Highly Active Anti-Retroviral Therapy (HAART) used to treat HIV/AIDS has serious side-effects, including metabolic complications from mitochondrial toxicities that can be life-threatening, and limit effectiveness and patient compliance. Adverse metabolic effects… more
Abstract:DESCRIPTION (provided by applicant): The long-range goal of this project is to restore functional movement to low-functioning stroke patients using a novel therapeutic regimen and robotic device called AMES, an acronym for Assisted Movement with Enhance
d Sensation. In AMES-as it is currently… more
Abstract:The previously conducted Phase I project had two goals: (1) to prototype and evaluate the feasibility of an intelligent computer-based task management application that would improve the ability of persons with cognitive disabilities to perform activities of daily living (ADL) and (2) to… more
Abstract:DESCRIPTION (provided by applicant): Responsible beverage service (RBS) training originated some quarter century ago to prevent driving under the influence among patrons of public drinking establishments, from which half of DUI arrests and alcohol-related
crashes originate. These programs train… more
Abstract:DESCRIPTION (provided by applicant): DesignMedix has developed a novel class of compounds to address the pressing need for an orally available, inexpensive drug to counter the spread of chloroquine-resistant malaria. Preliminary data showed that this novel
class of molecules, called reversed… more
Abstract:Wide-area networks are essential to productivity in commercial enterprises and military organizations. Reliability is difficult to achieve because wide-area networks, such as the Internet, are built from many autonomously configured component networks. Today there exists a large gap between the… more
Abstract:Highly productive, third-rotation commercial plantations have been successfully managed in the United States by the pulp and paper, timber, and the environmental-remediation industries for more than 40 years with great success in terms of wood yields and job creation. The success of the poplar… more
Abstract:DESCRIPTION (provided by applicant): Establishments that serve alcohol are a vast industry in America, but are unfortunately a common setting for aggressive and violent behaviors that are sometimes associated with alcohol consumption. Many servers (bartend
ers and wait staff) have limited training,… more
Abstract:DESCRIPTION (provided by applicant): During the first 3 years, children's long-term developmental trajectories are established, and the quality of parenting the child receives on a daily basis profoundly influences these trajectories. The transition to par
enthood is a difficult one for many parents… more
Abstract:This Small Business Innovation Research Phase II project aims to develop new, sensitive, accurate, and reliable detection methods for measuring genomic DNA or RNA samples isolated from living cells. The intellectual merit of this project lies in the development of new detection methods that are… more
Abstract:DESCRIPTION (provided by applicant): The purpose of this project is to develop and evaluate a specialized online version of a marital education program for resource (i.e., foster, kinship, and adoptive) parents. The program, called Prevention and Relations
hip Enhancement Program (PREP), is a… more
Abstract:DESCRIPTION (provided by applicant): In Phase II we will complete and evaluate a Web-enhanced pre-service training program for prospective foster caregivers. The program, developed by the Institute for Human Services, is a standardized pre-service training
curriculum in current use nationally.… more
Abstract:DESCRIPTION (provided by applicant): This project will develop and evaluate a theoretically-based interactive multimedia program for use by parents and their adolescent children (10-14 years of age) to prevent adolescent pregnancy. The program will include
behaviorally focused communication skills… more
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