Abstract:DESCRIPTION (provided by applicant): The presence of Her-2, estrogen receptor (ER) or progesterone receptor (P) on breast cancer cells is a very important biomarker which facilitates physicians in making decisions on treatment schemes and in proposing prog
nosis of the disease. Current methods for… more
Abstract:DESCRIPTION (provided by applicant): This NIH SBIR project intends to develop a new generation of iron oxide nanoparticles as target specific MRI contrast agents for early detection of breast cancer. Recent advances in iron oxide synthesis in organic solve
nts at elevated reaction temperature allow… more
Abstract:DESCRIPTION (provided by applicant): The goal of this SBIR project is to develop a multiplexing method to simultaneously quantify the expression levels of biomarkers in heterogeneous tumor tissue. The current method for diagnostic and prognostic classifica
tions of biomarkers is based on… more
Abstract:This Small Business Innovation Research (SBIR) Phase II research project focuses on the development of a product line of miniature pumping systems for the controlled delivery of fluids in ultra-low flow rate range (nanoliters to microliters per minute). This line of micropump systems will provide… more
Abstract:This Phase I SBIR proposal seeks funding to develop a radiation-hardened circuit architecture to achieve SEU and SEL immunity by using delay-insensitive asynchronous logic, and to demonstrate its feasibility, effectiveness, and efficiency. Further, early studies reveal that an operational… more
Abstract:DESCRIPTION (provided by applicant): The main goal of this Phase I SBIR project is to optimize the fabrication process and demonstrate the feasibility of using a novel carbon-based nanopipette (CNP electroprobe) for penetration of cell membrane in single c
ells with minimal cell intrusion and allow… more
Abstract:DESCRIPTION (provided by applicant): Vegrandis proposes to develop a rapid, sensitive, high throughput, inexpensive, and easy to use system for the ante-mortem diagnosis of prion infection. The proposed system offers a fully automated equipment with a disp
osable microelectrochemical cartridge for… more
Abstract:DESCRIPTION (provided by applicant): The ultimate goal of this STTR proposal is to develop a rapid, sensitive, and specific diagnostic test that can identify acetaminophen (APAP) protein adducts in human sera. APAP toxicity is the most common cause of acut
e liver failure (ALF) in the United States… more
Abstract:DESCRIPTION (provided by applicant): It is proposed to develop a target for production of iodine-124 for commercial distribution and to develop a radiolabeling business for I-124 radiotracers. I-124 is an increasingly useful nuclide for positron emission t
omography, especially to label molecules,… more
Abstract:The objective of this proposal is to develop multi-echelon logistics management tools based on Agile principles and integrate them into the Manufacturing Repair Overhaul (MRO) environment. The Oklahoma City Air Logistics Center (OC-ALC) current processes are sub-optimized and focus on each… more
Abstract:The objective of this proposal is to develop inventory flow tools based on Just In Time (JIT) principles and integrate them into the Manufacturing Repair Overhaul (MRO) environment. The Oklahoma City Air Logistics Center (OC-ALC) current processes vary greatly based on the specific needs of an… more
Abstract:APEI, Inc. is proposing to develop a low profile, non-intrusive, high temperature (300 degrees C) bearing data transmitter system that will allow the in-situ monitoring and diagnostic of bearing health. The proposed high-temperature data transmitter system will be built on high temperature… more
Abstract:Advances in radar systems are pushing the limits of present radar power supply technology. To enable new concepts, such as active array radar systems, significant improvements (i.e., power densities >200 W/in3, efficiency > 90%, transient response < 10 s, etc.) in radar power supply technology is… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project seeks to develop an advanced flexible self-powered robust high power density solid-state circuit breaker (SSCB) through the incorporation of emerging silicon carbide (SiC) device technology and the implementation of advanced thermal… more
Abstract:This project will develop high-voltage, high-performance Solid-State Fault Current Controller (SSFCC) technology, needed to minimize recovery time and vulnerability of the electricity network in the event of a large-scale natural disaster. The SSFCC technology, which utilizes Silicon Carbide (SiC)… more
Abstract:The terminal objective of this Phase II work will be the development of compact, fully integrated, high-temperature (250 degrees C), high-power-density SiC-based motor drives for avionics applications. The developed multi-chip power module (MCPM) will target an advanced motor drive application such… more
Abstract:Fast and accurate fault protection and isolation has always been an important feature of electric networks; in particular, this includes high reliability and robust networks such as the electric distribution systems of US Navy warships. This feature, however, is now critical for the development of… more
Abstract:Nosocomial transmission of multi-drug-resistant microorganisms in combat support hospitals is a well-recognized and growing problem. BioDetection Instruments proposes a rapid, simple and safe method for reducing contamination in hospital wards with a novel bacteriophage-based aerosol application. … more
Abstract:This SBIR Phase II project completes the design, construction, and testing of the largest readily portable Supersaturated Dissolved Oxygen (SDOXTM) injection system developed in smaller scale in Phase I. During the first year of the project, the SDOX will be used to study the effect of dissolved… more
Abstract:This Small Business Innovation Research Phase I research develops a bacteriophage-based spray/dip to disinfect whole or sliced fresh produce. This research will utilize key patent pending processes that will reduce the cost and safety concerns of commercial-scale production of bacteriophage… more
Abstract:This Small Business Innovation Research Phase I research project will develop a versatile high throughput bioassay system. The proposed system will be built on a patent-pending biosensing technology that has been exclusively licensed from the University of Arkansas. Using this technology, the… more
Abstract:DESCRIPTION (provided by applicant): This Small Business Innovation Research Phase I project will develop a reagentless biosensor for online monitoring of microbial contaminants in drinking water. The biosensor is based on incorporating several newly emerg
ing technologies into BioDetection… more
Abstract:DESCRIPTION (provided by applicant): This Small Business Innovation Research Phase I project will develop an innovative biochip for rapid screening of pesticide residues in water and food samples. The proposed biochip will be built on BioDetection Instrume
nts' exclusively-licensed patented… more
Abstract:DESCRIPTION (provided by applicant): In this Phase II project, BlueInGreen, LLC will build a hypersaturated dissolved ozone (HYDOZTM) unit to deploy in a large pilot-scale study at Springdale Wastewater Treatment Facility (SWWTF) in Springdale, Arkansas. F
urthermore, BlueInGreen will collaborate… more
Abstract:The primary focus of this project is to develop new high valued health related agricultural products through the application of biotechnological research approaches. Domestic and wild fowl, as the disease reservoir for avian influenza virus, play a central role in the re-emergence of this… more
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