Abstract:DESCRIPTION (provided by applicant): The majority of ovarian cancer patients have advanced disease at the time of diagnosis, and ovarian cancer has the highest mortality rate among gynecological malignancies. Immunotherapy based on induction of tumor-specific cytotoxic T lymphocyte (CTL) responses… more
Abstract:DESCRIPTION (provided by applicant): Despite many applicable developments in the field of ergonomically improved manual drive wheelchairs, the standard fixed pushrim remains the most prevalent method of propulsion. These ubiquitous fixed pushrim drives, while inexpensive and intuitively simple to… more
Abstract:DESCRIPTION (provided by applicant): Current conventional manual standup wheelchairs have serious drawbacks: propulsion requires suboptimal arm ergonomics, they are biomechanically inefficient, and they only allow manual mobility in a sitting position. We propose the development of a manual… more
Abstract:DESCRIPTION (provided by applicant): The purpose of this research is to determine the feasibility of a unique eye-tracking concept for controlling assistive devices. This access method may be exceptionally tolerant of head movement and can theoretically determine where the eye is targeted on a… more
Abstract:DESCRIPTION (provided by applicant): The objectives of the project are to develop an upper extremity orthosis that acts as an assistive device and a therapeutic tool. This will be done by using an existing prototype called the WREX - which was developed at the A.I. duPont Hospital for Children-… more
Abstract:DESCRIPTION (provided by applicant):
The proposed project is to develop an instrument for cell biology research based on a technique for perturbing local cytosolic concentrations of key signal transduction mediators with sustainable submicrometer resolution. In this technique, microspheres are… more
Abstract:This Small Business Innovations Research Phase I project is to develop a new generation of sensitive, rapid, portable, robust and inexpensive biosensor for simultaneous detection of multipe watergorne pathogens in water products and environment. Specificaly, NN-labs team will develop new biomarkers… more
Abstract:This Small Business Innovation Research (SBIR) Phase I research project intends to develop commercial scale production protocols for high quality, highly stable, biocompatible, bio-accessible, and yet affordable magnetic Fe3O4 nanocrystals. Current state-of-the-art methodology used to make Fe3O4… more
Abstract:DESCRIPTION (provided by applicant): This NIH SBIR project intends to develop three product lines of near infrared (NIR) bio-medical labeling reagents based on semiconductor nanocrystals (NIR NanoLabels), including conventional core/shell nanocrystals, type-II core/shell nanocrystals, and quantum… more
Abstract:This Phase II proposes to develop an innovative nanostructured coating, with a unique integration of hard phases and lubrication phases, for dry machining of austenite steels for the automotive and aerospace industries. This novel coating will be synthesized using a combination of electrostatic… more
Abstract:DESCRIPTION (provided by applicant): It is proposed to develop a nanoparticle coating of hydroxyapatite (HAp) on titanium dental implants. Osseointegration is of critical importance in dental implant surgical operation because it is affected by the proper selection of construction materials, design,… more
Abstract:We have developed an innovative lensless optical power limiting system for green region exploiting photoanisotropy of azobenzene films for low power continuous wave and high power nanosecond pulsed lasers (also with picosecond in solutions). It is a promising technique for next generation laser eye… more
Abstract:This NASA SBIR project will develop modular spray-cooled assemblies that satisfy NASA power and mass budgets and can be scaled to cool multiple heat sources subjected to high heat fluxes and microgravity conditions. Much of the work on spray cooling has been experimental in nature and technological… more
Abstract:SFC Fluidics in coordination with the University of Arkansas proposes to develop an immunoassay based lab-on-a-chip using the advantages of self-contained microelectrochemical detection and redox magnetohydrodynamic (MHD) microfluidics for the rapid detection of biomarkers of traumatic brain injury… more
Abstract:Space Photonics proposes a miniature, low power, high speed, optical communications turret utilizing a unique system design requiring no gimballing. This technology and design enables optical communications turrets specifically for unmanned aerial vehicle (UAV) and other airborne vehicle… more
Abstract:The Managed FPGA is a system component that contains a Field Programmable Gate Array (FPGA), System-on-a-Chip (SoC), and security features, packaged within a Multichip Module (MCM), that make this enhanced FPGA a sustainable, upgradeable component for use in DoD applications. Innovations include… more
Abstract:This Small Business Innovation Research (SBIR) Phase II project aims to develop an automated instrument for rapid and specific detection of waterborne pathogens in municipal water supplies using methods combining immunoassay with electrochemistry. Although the disposable cartridges for this… more
Abstract:Cryptosporidium parvum, a protozoan parasite that invades the gastrointestial system, is a serious threat to the nation's water supply. Assays for pathogen using self-contained microelectrochemical detection are desirable because precise detection can be performed with simple instrumentation on… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project will use a novel self-contained micro-electrochemical detection technology to measure the human protein response to specific biological agents. The end result will be an embedded computer controlled, automated, hand held device that… more
Abstract:DESCRIPTION (provided by applicant): Pig-to-human xenotransplantation may alleviate the critical shortage of organs available for transplantation. However, hyperacute rejection (HAR), acute vascular rejection (AVR), and cell-mediated rejection pose significant immunological hurdles to making… more
Abstract:Although biocontrol technology, including mycoherbicides, has been investigated for a long period of time, few products have actually made it into the commercial loop. The reasons for this are varied and include unfavorable environmental conditions, small markets and poor shelf-life. The test… more
Abstract:This Small Business Innovation Research (SBIR) Phase II research project will develop highly miniaturized power converters by developing a functional, scaled-down hardware prototype of a high-temperature multichip power module (MCPM). To achieve this goal, the company has taken advantages of the key… more
Abstract:This Phase II SBIR proposal seeks to develop high-temperature electronics by integrating motor drive control and SiC power electronics into a single, compact, highly efficient, reliable, high power density multichip power module (MCPM). Phase II will build upon the Phase I "proof of concept"… more
Abstract:This Small Business Innovation Research (SBIR) Phase II project will develop a portable, rapid and specific capillary channel based immuno-sensing system for food pathogens. The tests will be able to detect concentrations of
Abstract:This Small Business Innovation Research (SBIlR) Phase I project will develop a portable device for oxygenating streams and other surface water bodies using a combination of aeration and Dissolved Air Flotation (DAF), a process often used in settling tanks.
The commercial application of this… more
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