Abstract:The DoD requires an increase in performance and density of solid propellants for use on boost, strategic and tactical missile systems. Attaining ingredients with higher energy and density while simultaneously maintaining satisfactory physical properties is extremely challenging. Current low-cost… more
Abstract:The treatment of glyoxal with benzyl amine or allyl amine towards the formation of the corresponding tetraazaisowurtzitane cage structure has established a cornerstone in the preparation of caged nitramines and has led to significant research aimed at converting these precursors into compounds of… more
Abstract:Preparation of caged nitramines has led to significant research aimed at converting these precursors into compounds of interests such as CL-20. This unique ability highlights the fine balance required from electronic and steric contributions in the formation of the cage structure. We propose to… more
Abstract:Current Thermally Initiated Venting Systems (TIVS) consist of a thermal sensor, trigger, out-of-line blocking device, initiator, transfer energetic, and linear-shaped charge. TIVS reduce the reaction violence of munitions exposed to cook-off events by scoring the case of the rocket motor, not… more
Abstract:The NASA objective of expanding the human experience into the far reaches of space requires the development of regenerable life support systems. This proposal addresses the development of an integrated air-revitalization system for the space suit used in Extravehicular Activities (EVAs). The… more
Abstract:Mathematical models of physical and biological systems contain parameters that need to be estimated from measured data. Models with parameters distributed probabilistically require the estimates of a probability measure over the set of admissible parameters. We propose to use frequentist-based… more
Abstract:Abstract The ability of the immune system to recognize and initiate an immune response to foreign particles such as bacteria and viruses has generated interest in development of particulate vaccine technologies. We are developing an innovative approach toproduce particulate vaccines via… more
Abstract:Abstract This Phase II project will develop a novel synthetic microparticle vaccine for malaria, using the T1BT* epitopes of the circumsporozoite (CS) protein of Plasmodium falciparum, the causative agent of human malaria. There is no approved vaccine formalaria, a disease that causes up to 500… more
Abstract:The proposed project is to demonstrate a novel technique for producing GaN single-crystal boules that yield GaN wafers and substrates suitable for fabrication of GaN high-power devices. The two key attributes of the proposed novel GaN growth technique (a bulk crystal growth technique) are: a high… more
Abstract:Global Engineering and Materials, Inc. (GEM) along with its team members (National Institute for Aviation Research (NIAR) at Wichita State University, Carnegie Mellon University, and Air Force Research Lab (AFRL)) will develop an add-on toolkit for Abaqus with high fidelity prediction of residual… more
Abstract:ABSTRACT: Global Engineering and Materials, Inc. (GEM) along with its team member Columbia University propose to develop a simulation tool for modeling mixing process of multi-particle composite systems and generating the ultimate microstructure. A combined theoretical, numerical, and experimental… more
Abstract:Through this project, investigators will evaluate a novel nutritive immune-enhancing delivery system (NIDS) to assess its potential to lower the dose requirement for pandemic influenza vaccines. PUBLIC HEALTH RELEVANCE
Abstract:DESCRIPTION (provided by applicant): Over 34 million people are currently living with HIV/AIDS. Combination antiviral therapies have significantly reduced the morbidity and mortality of the disease; however, there is currently no cure for the disease. Discovery that a naturally occurring variant of… more
Abstract:ABSTRACT The long-term product goal of this project is a small molecule therapeutic for choroidal neovascularization (CNV, the hallmark of wet age-related macular degradation), an abnormal growth of blood vessels in the choroid layer of the eye that results in damage to the retina and consequent… more
Abstract:DESCRIPTION (provided by applicant): This proposal seeks to develop a novel vaccine against Lyme disease -- by targeting Ixodes scapularis proteins critical for Borrelia burgdorferi transmission from the tick to mammalian host. Earlier work has identifiedfour tick proteins, Salp15, TRE31, tHRF and… more
Abstract:DESCRIPTION (provided by applicant): Leptospirosis, a zoonotic disease, is an important public health problem worldwide. It is caused by spirochete bacteria belonging to nine species and more than 200 serovars of the genus Leptospira. In the US, there is increasing awareness of the importance of… more
Abstract:DESCRIPTION (provided by applicant): All forms of diabetes are characterized by the death of insulin producing ? cells. In Type 1 diabetes (T1D) this leads to the reliance on exogenous insulin for survival. Death of ? cells is silent - it cannot be detected in vivo until it has progressed to such an… more
Abstract:DESCRIPTION (provided by applicant): Lyme disease (LD) caused by the Ixodes tick-borne spirochete Borrelia burgdorferi (Bb), is the most common vector-borne disease in the United States. Despite public health preventive measures, the annual confirmed caseincidence has risen to over 30,000, the vast… more
Abstract:DESCRIPTION (provided by applicant): Current testing for Lyme disease is suboptimal because it requires two assay platforms, including one with subjective interpretation of results, and because it has lower sensitivity in the early stage of the illness. Infection with Borrelia burgdorferi, the… more
Abstract:Advanced wing configurations where traditional control surfaces are replaced by dynamically controlled distribution of wing twist and/or camber can provide significant benefits to aircraft performance, such as reduced vibration and noise, increased fuel efficiency. Elimination of traditional control… more
Abstract:Dielectric materials are ubiquitous in accelerator structures for discovery science, industrial and medical applications. Further use of dielectrics in advanced accelerators, such as the dielectric wake field accelerator, also promises improved performance and cost savings. But undesirable… more
Abstract:The overall goal of this proposed project (through Phase III) is to develop a field-ready, easy to use Pathogen Analyzer to rapidly identify, quantify, and characterize viability of microbial pathogens in food and water at the required sensitivity (e.g. 1-1000 cfu/g). During the Phase I project,… more
Abstract:The goal of this proposed program through Phase III is to build a space-worthy Drug Stability Analyzer that can determine the extent of drug degradation. It will be able to monitor the drug active pharmaceutical ingredient (API) and its degradation product concentrations as a function of time, as… more
Abstract:DESCRIPTION (provided by applicant): The overall aim of this SBIR program is to develop a surface-enhanced Raman spectroscopy (SERS) based device for point-of-care analysis of drugs in patient saliva. This device will allow immediate assessment of both prescription and illicit drug use by patients… more
Abstract:Precision Combustion, Inc. (PCI) proposes an ultra-compact JP-8 fueling system that will enable a lightweight spark-ignited engine as a man portable multi-fueled 1 1.5 kW generator. This is based on a breakthrough fueling technology that is different from vaporization approaches. This enables… more
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