Abstract:DESCRIPTION (provided by applicant): The goal of this application is to empower anxiety disorders researchers to manage, share, and repurpose their research data more effectively throughout the research lifecycle by delivering an open--source, integrated data management platform that meets their… more
Abstract:DESCRIPTION (provided by applicant): Since the first procedure in 2002, there has been an explosive growth in transcatheter aortic valve replacement (TAVR). Up to date, more than 50,000 TAVR had been performed worldwide. Despite the increased global experience with TAVR, severe adverse events… more
Abstract:DESCRIPTION (provided by applicant): A flexible, protein-based, ion-mediated retinal implant is proposed for the restoration of vision for patients with retinal degenerative diseases, such as age-related macular degeneration (AMD) and retinitis pigmentosa(RP). The implant under development uses the… more
Abstract:DESCRIPTION (provided by applicant): This aim of this Phase I SBIR proposal from Applikate Technology, LLC, is to validate the use of ClearView, a novel approach to performing complete and non-destructive imaging of tissue specimens, for primary pathologyof lung biopsies. Error rates for diagnoses… more
Abstract:Solid oxide fuel cells (SOFCs) offer exceptional promise for electrical power generation with reduced carbon footprint, but SOFC reliability must be improved for the technology to be widely commercialized. SOFCs utilize ferritic stainless steel sheets as… more
Abstract:This proposal describes a novel method for the refrigeration and storage of food products that does not use electricity and is cleaner for the environment than any method currently in use. Our concept addresses many important economic and social development issues facing rural America such as access… more
Abstract:The broader impact/commercial potential of this project is in enabling the development of inexpensive miniature pumps that can be integrated with bandages in order to apply negative pressure therapy to wounds. Negative pressure wound therapy (NPWT) is the most commonly prescribed therapy for wounds… more
Abstract:Our objective is to design and build a compact system that provides turnkey readiness for commercial and defense use of SNSPDs. Conventional SNSPDs face several limits that lead to tradeoffs between detection efficiency, bandwidth, dark count rate, jitter
Abstract:A great deal of progress has been made in delivery of highly mature building systems energy simulation tools. However, application of these highly sophisticated methods tends to remain limited to a relatively small population of high profile buildings. Elements that influence this limitation… more
Abstract:The Automated Ply Inspection (API) system autonomously inspects layups created by high speed automated fiber placement (AFP) machines. API comprises a high accuracy line scanner to measure surface topology of as-made layups driven by a precision articulated arm Robot to perform rapid surface… more
Abstract:DESCRIPTION (provided by applicant): The overarching goal of Phase I is to produce a method that will generate, identify and clone a catalog of protein-protein interactions in a single rapid experiment. In this proposal we will model the technology using antibody-antigen interactions. Recombinant… more
Abstract:DESCRIPTION (provided by applicant): Site-specific binding of proteins to DNA plays an important role in cell development, cell signaling, the cell cycle, and diseases such as cancer. There are two overarching goals to this proposal: (1) to develop a meansfor the identification of proteins bound to… more
Abstract:DESCRIPTION (provided by applicant): Unhealthy behaviors such as smoking, medication non-adherence, and lifestyle habits leading to obesity are major contributors to premature morbidity and mortality among the U.S. population. Participation rates in programs designed to improve these behaviors are… more
Abstract:The broader impact/commercial potential of this Small Business Innovation Research (SBIR) Phase II project results from the development of a new class of graphical-media-design system that lies between today's 2D digital paint systems and 3D computer-aided design systems. This technology will… more
Abstract:DESCRIPTION (provided by applicant): Lung cancer is the leading cause of cancer death in the United States and is responsible for more deaths each year than breast, prostate, colon, hepatic, renal and skin cancers combined. Viewed in economic terms, in theUnited States, the value of life lost from… more
Abstract:The proposed innovation is the development of a cathode feed electrolysis cell stack capable of generating 3600 psia oxygen at a relevant scale for future exploration missions. This innovation is relevant to NASA's need for compact, quiet, efficient, and long-lived sources of pressurized… more
Abstract:Industrial processes for production of ammonia (NH3) and urea nitrogen-based fertilizers aremainly based on the Haber-Bosch process, which involves the heterogeneous reaction ofnitrogen (N2) and hydrogen (H2) on an iron-based catalyst at high pressure (150-300 atm) andhigh temperature (400 &… more
Abstract:DESCRIPTION (provided by applicant): As the Alzheimer's disease (AD) population is growing rapidly, currently there are no cure treatments. The goal of this resubmitted STTR proposal is to conduct a preclinical study with pramlintide to prove a potential treatment for AD. We have revised the… more
Abstract:SpeechPrompts will be an application for Apple iOS devices (iPad, iPhone, iTouch) for use by special education professionals and other caregivers (e.g., special educators, paraprofessionals, SLPs, counselors, and parents) working with students in kindergarten through grade 12 who exhibit prosodic… more
Abstract:ABSTRACT: The DoD requires increased performance and increased density solid propellants for use on boost, strategic and tactical missile systems, however, simultaneously attaining higher energy and density while maintaining satisfactory physical properties is an extremely challenging goal. Current… more
Abstract:New technology is needed to collect, stabilize, safen, recover useful materials, and store human fecal waste for long duration missions. The current SBIR Phase I proposal will examine an innovative torrefaction (mild pyrolysis) processing system that can be used to sterilize feces and produce a… more
Abstract:The NASA objective of expanding the human experience into the far reaches of space requires the development of regenerable life support systems. This proposal addresses the development of an integrated air-revitalization system for the space suit used in Extravehicular Activities (EVAs). The… more
Abstract:The current NASA spacesuit community is focusing on utilizing a 13" hemispherical helmet for the next generation of extravehicular activity spacesuits. This helmet architecture presents the end user with a myriad of positive attributes, including a large field of view, enhanced CO2 washout and… more
Abstract:DESCRIPTION (provided by applicant): ABR's recent series of innovative randomized trials evaluating the efficacy of various strategies for training clinicians to use evidence based therapies in alcohol and drug abuse has indicated that while both in-personworkshop and computer-assisted training… more
Abstract:We propose to develop algorithms to improve debris management for electro-optical/infrared sensors (EO/IR) within C2BMC. Our goal is to improve fire control solutions, increase the quality of communicated sensor information, and reduce communication demands. We characterize the pre-intercept… more
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