Abstract:Use of data from multiple sensors provides the opportunity for improved ballistic missile defense search and tracking. Algorithms for combining multi-sensor data are required. Ballistic missile defense sensor data fusion is a challenging problem because of incompatibility in coordinate systems for… more
Abstract:Sonar performance predictions are often unreliable due to the lack of accurate information about the acoustic properties of the ocean around the globe. We propose to demonstrate an environmental estimation technique that uses reverberation from active sonar transmissions to infer environmental… more
Abstract:Applied Physical Sciences Corp. (APS) will develop designs and proof-of-concept devices to demonstrate a marine mammal detection capability for a variant of the AN/SSQ-125 active source sonobuoy. Acoustic transducers, signal processing algorithms, and data interfaces will be developed and tested.… more
Abstract:The Phase II effort consists of a 12-month Base and two 6-month Options. The Base is centered on the design, fabrication, and test of a prototype projector and power electronics. Testing is planned at NUWC Seneca Lake to evaluate the projector"s electro-acoustic performance. The first Option is… more
Abstract:DESCRIPTION (provided by applicant): Type 1 Diabetes (T1D) affects more than 1 million people in the United States Source ADA http://www.diabetes.org/about-diabetes.jsp and is usually diagnosed in children and can lead to blindness, heart disease and kidney failure. A major focus of intervention… more
Abstract:DESCRIPTION (provided by applicant): The proposed work will result in a characterized prototype instrument that will facilitate the identification of a broad range of analytes in small volumes of human blood, urine, saliva and other readily obtainable biological fluids with little sample preparation… more
Abstract:DESCRIPTION (provided by applicant): The objective of this Phase I SBIR proposal is the development of a novel instrumentation platform based on Surface Plasmon Resonance (SPR) that if validated would greatly increase the utility of this label-free technology to researchers utilizing high-content… more
Abstract:DESCRIPTION (provided by applicant): Polymicrobial infections are of great concern to the research community because they have a dramatic impact on the productivity research groups, on the reliability of experimental results, and on the progress that can be made in unraveling fundamental biological… more
Abstract:Dried blood spot (DBS) analysis has gained recognition in recent years in basic science and clinical diagnostics. This impetus relies upon its numerous advantages over the collection, transport and storage of blood samples obtained by conventional venipuncture. Although there is wide-spread interest… more
Abstract:This Small Business Innovation Research (SBIR) Phase II project aims to develop a wireless, needle implantable miniaturized (0.5 x 0.5 x 5 mm) sensor for continuous glucose monitoring, with provisions for internal self-calibration that ultimately eliminates the need for frequent, external… more
Abstract:A combined discrete cohesive interface fracture and continuum damage mechanics initiation and propagation toolkit for Abaqus will be developed for the residual strength prediction of adhesively bonded composite structures subjected to multi-axial loading. This tool will allow us, for the first time,… more
Abstract:Global Engineering and Materials, Inc. (GEM) along with its team members Northwestern University, Lockheed Martin, and Boeing Company, propose to develop an automatic software tool for 2D/3D fatigue crack growth prognosis of complicated structures under multi-axial loading. The XFAT toolkit will be… more
Abstract:A Probabilistic Fatigue Damage Assessment Network (PFDAN) toolkit for Abaqus will be developed for probabilistic life management of a laminated composite structure with both microcracking induced stiffness degradation and cyclic loading induced delamination crack growth without remeshing. It is… more
Abstract:A hybrid damage initiation and propagation toolkit for Abaqus will be developed for residual strength and life prediction of adhesively bonded composite structures. This tool will for the first time be able to simulate concurrently both the continuum and discrete damage based progressive failure… more
Abstract:ABSTRACT: A Hybrid Structure Evaluation and Fatigue Damage Assessment (HYSEFDA) toolkit for Abaqus will be developed for advanced hybrid structures under multi-axial and variable amplitude cyclic loading. The tool will be able to characterize arbitrary geometric configurations of fiber metal… more
Abstract:A fully coupled fire-structure interaction module will be developed and implemented within GEM"s Abaqus Fire Interface Simulator Toolkit (AFIST) for fire response prediction in aluminum ship structures. This enhanced AFIST will be able to characterize a 3D complex geometry where its topology is… more
Abstract:DESCRIPTION (provided by applicant): The long-term product goal of this project is a small molecule therapeutic to treat rheumatoid arthritis (RA), which acts by reducing the inflammatory response triggered by the pro-inflammatory cytokine macrophage migration inhibitory factor (MIF). Since MIF is… more
Abstract:DESCRIPTION (provided by applicant): All forms of diabetes are characterized by the death of insulin producing cells. In Type 1 diabetes (T1D), this leads to the reliance on exogenous insulin for survival. In addition, there is cell loss in T2D and inindividuals who lose islet or pancreas… more
Abstract:Flaviviruses enter mammalian cells by a mechanism involving a structural rearrangement of the stem region of their envelope protein. The stem region establishes specific molecular contacts with amino acid residues of domain II of the rest of the envelope protein. Our hypothesis is that tetrapeptides… more
Abstract:DESCRIPTION (provided by applicant): Lyme disease, due to infection with the Ixodes tick-transmitted spirochete Borrelia burgdorferi, is the most common vector-borne disease in the United States, with over 38,000 confirmed and probable cases reported to the CDC in 2009. Spirochetes first establish… more
Abstract:DESCRIPTION (provided by applicant): This is a proposal to test the feasibility of using triplex molecules for use as a therapeutic to correct Hurler Syndrome (HS). Lysosomal storage diseases (LSDs), such as HS, represent a diverse collection of monogenicdisorders that have devastating clinical… more
Abstract:DESCRIPTION (provided by applicant): Fungal infections continue to be a major cause of morbidity and mortality among HIV-infected patients. Many of the emerging fungal pathogens that are resistant to the three classes of antifungal agents for AID-s-relatedinfections are becoming more common and are… more
Abstract:The Exercise Load Measurement Insole (ELMI) is a system that is designed to measure normal and shear foot forces during exercise. The ELMI system is lightweight, portable, unobtrusive, and its versatility allows it to be used for many purposes outside of exercise load measurement and study. At the… more
Abstract:Considerable research and development effort has been devoted to improving seating in helicopters since the early 1960s when the need for improved ergonomics and crashworthiness was first established. Yet currently a typical rotorcraft crew/pilot seat uses only passive shock absorbers for mediocre… more
Abstract:The overall goal of this Army SBIR program is to develop innovative solutions for mitigation of high-frequency rotor induced whole body vibration of seated occupants in helicopters while providing failsafe adaptive crash safety that surpasses the limited protection provided by the current… more
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