Abstract:Applied Physical Sciences Corp. proposes to develop a Marine Mammal Mitigation Miniature Acoustic Detection Subsystem (MADS) for the AN/SSQ-125 active source sonobuoy or similar system. MADS will consist of a miniature high-frequency active sonar array for detection and tracking of marine mammals… more
Abstract:DESCRIPTION (provided by applicant): The goal of this project is to produce novel synthetic malaria vaccines based on epitopes of the circumsporozoite (CS) protein of Plasmodium falciparum, the causative agent of human malaria. Malaria is one of the major
diseases in the developing world, causing… more
Abstract:DESCRIPTION (provided by applicant): The introduction and implementation of highly active antiretroviral therapy (HAART) in AIDS patients diminished HIV viral load and led to an increase in life expectancy, but HIV infection can still lead to severe complications in the nervous system such as… more
Abstract:DESCRIPTION (provided by applicant): The long-term objective of the proposed effort is to develop an autonomous clinical diagnostics system for monitoring normal and diseased immune function that occurs in the context of rheumatoid arthritis, infection
, inflammation, asthma, autoimmune disease,… more
To detect and identify vapors of contraband currency, not to mention a selection mode for explosives, narcotics, chemical warfare agents, biological threats or other analyte species at trace levels in air, is an important problem with many ramifications. One… more
Abstract:DARPA SBIR solicitation SB082-011 seeks the design and development of high power density electric motors for hybrid electric air platforms, indicating a need for a prototype motor rated at 7 hp, weight less than 1.4 lbs, efficiency greater than 95% and operating at speeds less than 10,000… more
Abstract:The continuing demand for improving the capabilities of Full Authority Digital Engine Control (FADEC) systems while reducing their size, weight and cooling requirements has led to investigations of alternate architectures and electronic devices for the next generation of advanced propulsion systems.… more
Abstract:The Intelligent Sensor Node (ISN) Phase I program successfully demonstrated the feasibility of implementing a high temperature capable, reconfigurable node that can interface with most types of control sensors found in today's propulsion control systems. The proposed Phase II program is aimed at… more
Abstract:FuelCell Energy, Inc., in collaboration with the University of Minnesota, is proposing to develop an innovative fuel processor for person-portable fuel cell power system applications. The system will be designed to reform butanol into a hydrogen-rich stream suitable for use in a low-temperature… more
Abstract:With the depletion of fossil fuel reserves, hydrogen-based energy is becoming increasingly significant. Production, purification and compression of hydrogen represent key technical challenges. Hydrogen is most commonly produced from steam methane reformers, by gasification or as a refining or… more
Abstract:This Small Business Innovation Research (SBIR) Phase II project is to demonstrate a novel technique for producing large-diameter freestanding GaN wafers and substrates. Despite the research efforts in the last decade, affordable GaN wafers and substrates of large diameters have not been widely… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project will investigate a novel technique for growing large-diameter, high-quality ZnO single crystals. ZnO single crystal substrates are suitable for fabrication of epitaxial structures for both GaN-based and ZnO-based devices, such as light… more
Abstract:Cypripedium is a genus of temperate terrestrial ladyslipper orchids of excellent garden size, forming clumps or 12 - 18 inches in diameter or more, with very showy flowers. Many species are easy to grow in northern gardens (USDA zones 2-7) and have excellent horticultural potential. Today, several… more
Abstract:The goal of this proposal is to demonstrate the feasibility of new multi-scale models for linking higher order micro-structure descriptions to failure initiation and crack propagation for high cycle fatigue of high strength titanium alloys. This includes new high temperature materials such as the… more
Abstract:A software tool for fracture evaluation and load deflection prediction of welded aluminum ship structures subjected to impulsive loading will be developed by enhancing and integrating an existing extended finite element method (XFEM) for dynamic fracture of thin shells in Abaqus. The software… more
Abstract:DESCRIPTION (provided by applicant): This is a proposal to test the feasibility of using triplex-forming oligonucleotides to correct the sickle cell disease (SCD) mutation in human CD34+ cells. SCD is one of the most common human genetic diseases and is th
e result of one specific inherited mutation… more
Abstract:The proposed innovation is a static, cathode-fed, 2000 psi, balanced-pressure Advanced Cathode Electrolyzer (ACE) based on PEM electrolysis technology. It electrolyzes water vapor supplied to the hydrogen-evolving electrode and eliminates the need to circulate hydrogen and water on the cathode side… more
Abstract:NOAA uses large-format aerial film cameras to collect data for monitoring marine mammal populations protected under the Marine Mammal Protection Act and the U.S. Endangered Species Act. Historically, the major users of these cameras have been the military and… more
Abstract:We propose a suite of nonlinear image processing algorithms derived from the analysis of the underlying diffusion geometry of a collection of hyperspectral images of interest. These tools enable the comparison of spatio-spectral features of hyperspectral images acquired under different conditions,… more
Abstract:DESCRIPTION (provided by applicant): Oligodendrocytes (OLs) are the myelinating cells of the central nervous system and play a critical role in white matter formation. Serious clinical disorders affect central nervous system white matter during early devel
opment. These conditions include… more
Abstract:DESCRIPTION (provided by applicant): Fragile X Syndrome (FRAX) is the most common genetic cause of mental retardation in males. FRAX is caused by the expansion of a CGG trinucleotide repeat of the 5' untranslated region (UTR) of the FMR1 gene. In norma
l individuals, the 5' UTR of the FMR1 gene… more
Abstract:DESCRIPTION (provided by applicant): Lyme disease, due to infection with the Ixodes tick-transmitted spirochete Borrelia burgdorferi, is the most common vector-borne disease in the United States, with over 20,000 cases reported to the CDC annually. There i
s controversy over the length of antibiotic… more
Abstract:DESCRIPTION (provided by applicant): Exposure to isocyanate, the essential cross-linker for making polyurethane, is a leading cause of occupational asthma world-wide. Three major types of isocyanate are used commercially, methylene-diphenyl diisocyanate (MDI) and toluene diisocyanate (TDI), or… more
Abstract:DESCRIPTION (provided by applicant): Epidermal Growth Factor Receptor (EGFR) bearing tumors remain as one of the most insidious and difficult to treat human malignancies, affecting thousands of individuals each year. Our proposed studies are aimed at developing novel tumor immunotherapy by using… more
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