Abstract:DESCRIPTION (provided by applicant): The goal of this Phase I SBIR is the pre-clinical development of a novel gene-based delivery system for bevacizumab (anti-VEGF antibody) to treat wet age-related macular degeneration (AMD). The premise is based on: (1)the demonstrated efficacy of monthly… more
Abstract:ABSTRACT: Our objective is to develop a vision system for a micro air vehicle (MAV) or other robotic system that allows it to operate in extremely low light levels. We will develop systems capable of operating in ambient light or with active illumination carried aboard the vehicle, and will explore… more
Abstract:The objective of this project is to develop a software based FOB energy simulation model that will enable the USMC to effectively analyze FOB energy efficiency under various configurations and assess the impacts of current and emerging conventional and alternative power systems. At the end of Phase… more
Abstract:DESCRIPTION (provided by applicant): Brain ischemia is a leading cause of morbidity and mortality in the United States. We seek to develop therapeutics to reduce the extent of damage and functional impairment resulting from ischemic injury to the brain, anarea of significant unmet medical need. We… more
Abstract:DESCRIPTION (provided by applicant): Early identification of developmental problems and delays means that interventions can begin sooner and are more effective and less resource-intensive than later interventions, after a problem has festered and worsened.Despite these benefits, statistics indicate… more
Abstract:DESCRIPTION (provided by applicant): There is no more important target audience for smoking cessation efforts than pregnant women. The goal of this Fast Track project is to establish the scientific and technical feasibility of using an interactive text- and web-based application to support smoking… more
Abstract:Applied Research in Acoustics LLC will formulate and develop new concepts and algorithms for data-driven clutter-adaptive waveform-synthesis and CFAR normalization processing based on physical models of resonant backscattering from heterogeneous aggregations of swim-bladder-bearing fish that will… more
Abstract:DESCRIPTION (provided by applicant): Mucopolysaccharidosis type I (MPS I) is an autosomal recessive storage disease caused by the absence of a-L-iduronidase (IDUA), resulting in systemic accumulation of glycosaminoglycan (GAG) storage materials, hepatosplenomegaly, skeletal dysplasias,… more
Abstract:DESCRIPTION (provided by applicant): The overall goal of this project is to develop a novel gene-based delivery system to treat neovascular age- related macular degeneration (wet AMD), a debilitating ocular disease. AMD is the leading cause of blindness inAmericans over 60 years of age, with wet AMD… more
Abstract:The goal of this effort is to build a fully on-board vision based navigation system for small micro air vehicles (SMAVs) that will allow autonomous flight and navigation in a ship-borne environment. The target platform is a hovering air vehicle of 7cm to 20cm in size with a payload capacity between… more
Abstract:Consumers are now demanding more information about farm production processes and their resulting harvests. Harvest records, although difficult for farmers to capture, can contain rich product data such as grading information and macro and micronutrient content, allowing farmers to differentiate… more
Abstract:DESCRIPTION (provided by applicant): The overall goal of this application is to develop a quantitative in-vivo small animal imaging system for fluorescent reporter probes that fuses fluorescence light emitting computed tomography (FLECT) with X- ray computed tomography (CT). The proposed… more
Abstract:DESCRIPTION (provided by applicant): The long-term aims of this project are to improve the engineering practices of synthetic biologists, and thereby to hasten the pace of synthetic biology research. Synthetic biology is poised to make great contributions to health, medicine, energy, and the… more
Abstract:Marine Design Dynamics, Inc. is pleased to propose an advanced, analytical method for the development of concepts and systems to improve energy efficiency and reduce logistics requirements to sustain USMC Forward Operating Bases (FOB). In its simplest form, our concept is to provide a capability to… more
Abstract:DESCRIPTION (provided by applicant): The NIH Blueprint for Neuroscience Research is committed to implementing a ten-month initiative to create a proof-of-concept of the NITRC Image Repository (NITRC-IR). The goal of the NITRC-IR is to promote publication,indexing, and sharing of anonymized fMRI… more
Abstract:DESCRIPTION (provided by applicant): Treatment for head and neck squamous cell carcinoma (HNSCC) often confers considerable functional impairment. As a result, HNSCC patients experience significant decrements in quality of life, high levels of emotional distress, deteriorations in interpersonal… more
Abstract:DESCRIPTION (provided by applicant): healthEworks' mission is to improve discharge health education for the 100 million patients discharged from U.S. emergency departments (EDs) annually. healthEworks aims to accomplish this goal by creating and distributing Video Prescriptions - concise videos… more
Abstract:DESCRIPTION (provided by applicant): The overall goal of this application is to develop a quantitative in-vivo small animal imaging system for fluorescent reporter probes that fuses fluorescence light emitting computed tomography (FLECT) with X- ray comput
ed tomography (CT). The proposed… more
Abstract:DESCRIPTION (provided by applicant): The overall goal of this application is to develop a scalable production system for the manufacture of an adeno- associated virus (AAV) serotype 8-based gene therapy vector bearing a human low density lipoprotein recept
or (hLDLR) transgene for the treatment of… more
Abstract:This Phase I Technical Approach will provide the Government with an approach to identify, assess, and monitor the manner in which terrorist websites influence target audiences. Our approach is unique in that it applies psychological and sociological approaches to understanding the information and… more
Abstract:The objective of this research is to demonstrate the feasibility of developing a software toolkit to describe, define and create visual data models that can be dynamically linked into a spatial framework to facilitate more rapid understanding of complex data sets for leadership decision making. The… more
Abstract:Defense Group Inc. (DGI) proposes a unique approach to Cross Layer Modeling of JTRS MANETs. Our approach integrates admission control with congestion management schema. We propose a schema of "Intelligently" dropping packets with three possibilities for improved JTRS network throughput: 1) Using a… more
Abstract:DESCRIPTION (provided by applicant): The goal of the proposed research is to determine the feasibility of, and create prototype software for, a library of reusable synthetic biology components using Semantic Web technologies OWL, RDF, SPARQL and SWRL. Thislibrary will dramatically increase the… more
Abstract:While current Air Force logistics processes have served us well, and provided unparalleled support since the end of the Cold War, the need to significantly reduce costs while improving weapons system availability is essential. Senior Air Force officials have stated in numerous documents that the… more
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