Abstract:Multiple access protocols are used to permit large numbers of independent transmitters to share a common communication channel. CDMA was developed as a multiple access network protocol for military applications during the last forty years. Recently considerable interest in using CDMA in the civilian… more
Abstract:THE OVERALL GOALS OF THIS PROJECT ARE TO DEVELOP IMMUNOASSAYS FOR THE DETECTION OF BRYOSTATIN 1 AND ITS ANALOGUES IN A VARIETY OF BIOLOGICAL MATRICES. THE BRYOSTATINS HAVE EXHIBITED STRONG ANTINEOPLASTIC ACTIVITY IN PRECLINICAL STUDIES AND ARE SCHEDULED TO ENTER PHASE I CLINICAL TRIALS LATER THIS… more
Abstract:Murine monoclonal antibodies which neutralize maitotoxin will be selected using a functionalassay that exploits the hemolytic action of maitotoxin. The resulting antibodies should be useful forseveral purposes. They will provide a means to measure the toxin content in crude extracts of fishtissues… more
Abstract:Dengue viruses are a leading cause of morbidity and mortality throughout the tropics andsubtropics. It is estimated that more than 100 million people in the tropics are infected annually by thisvirus. This threat has now reached the southern United States with the arrival of the Aedes… more
Abstract:Several fundamental parameters need to be addressed with regard to the development of biosensors. Protein stability is a major criteria for sensors devoted to long-term monitoring. The enzyme label is typically the most unstable componenet in biosensors. Additional problems encountered with… more
Abstract:The filamentous fungi, owing to their ability to secrete high levels of proteins, are attractive organisms for the expression and secretion of heterologous proteins of commercial and medical value. Secretion is a key element in their attraction, for secretion enables proper folding and processing of… more
Abstract:Natural testosterone and numerous synthetic analogs are known to stimulate biosynthesis ofproteins and are used as therapeutic agents. Most of them are DEA controlled substances. Improper usemay cause health risks. Steroid abuse is a widespread problem. There is a practical need to screen forabused… more
Abstract:High rate-of-fire weapons are subject to significant barrel erosion as projectile velocity and burst lengths are increased. Bore temperatures exceeding the melting point of steel can be easily reached because of the low thermal conductivity of the steel barrel. Barrels comprised of copper/graphite… more
Abstract:High-power ammonia arcjet thrusters are being investigated as primary propulsion systems for carrying satellites into high altitude orbits. As a method to enhance the power levels and efficiency of the engine, the thermal emissivity of the outer anode surface must be substantially enhanced. Ideally,… more
Abstract:In the next generation of air-breathing high-performance engines, significant engine performance improvements are envisioned by combusting hydrogen with air in a regeneratively cooled carbon/carbon composite combustion chamber. Surfaces subjected to aerodynamic heating will also be cooled by… more
Abstract:THIS PHASE I PROJECT IS DESIGNED TO TEST THE FEASIBILITY OF PURIFYING TAXOL BY IMMUNOAFFINITY CHROMATOGRAPHY. THE USE OF THIS TECHNIQUE FOR PURIFICATION OF A LOW MOLECULAR WEIGHT COMPOUND WITH LOW AQUEOUS SOLUBILITY HAS NOT BEEN REPORTED TO DATE. TAXOL-SPECIFIC MONOCLONAL ANTIBODIES WILL BE SELECTED… more
Abstract:A Taxol prodrug derivative will be prepared. This compound will be tested for its differential cytotoxicity compared to Taxol and for its ability to be enzymatically activated. The cytotoxicity of the prodrug in combination with a monoclonal-antibody enzyme conjugate in the presence of targeted and… more
Abstract:THE DEVELOPMENT OF MICROBIAL SYSTEMS FOR EXPRESSION OF HETEROLOGOUS PROTEINS HAS ENABLED THE ISOLATION OF GREATER AMOUNTS OF SOURCE PROTEINS, OFTEN IN GREATER PURITY THAN IS POSIBLE FROM THE ORIGINAL SOURCE. PROTEINS SO EXPRESSED HAVE APPLICATIONS RANGING FROM INDUSTRIAL USE, THROUGH PROTEIN… more
Abstract:Regulation of gene expression is critical for cellular and organismal development, and it often plays an important role in expression of heterologous recombinant proteins. Toward development of regulated expression vectors for filamentous fungi that will minimize materials cost and manipulation of… more
Abstract:The filamentous fungi, owing to their ability to secrete high levels of proteins, are attractive organisms for the expression and secretion of heterologous proteins of commercial and medical value. Secretion is a key element in their attraction; secretion provides the opportunity for complex… more
Abstract:THE STRIPED SNAKEHEAD CHANNA STRIATUS IS A HIGHLY ESTEEMED FOODFISH IN SOUTHEAST AND SOUTH ASIA. MILLIONS OF FISH ARE CONSUMED ANNUALLY IN COUNTRIES OF THIS REGION. SEVERAL THOUSAND METRIC TONS OF FROZEN WHOLE SNAKEHEAD ARE ALSO IMPORTED ANNUALLY INTO NORTH AMERICA FOR SALE IN DOMESTIC ASIAN SEAFOOD… more
Abstract:KONA CINDER & SPOILS, INC. IS A SMALL-BUSINESS INVOLVED IN THE AGRICULTURAL/LANDSCAPE SOIL BUSINESS IN KONA, WEST HAWAII (ON THE ISLAND OF HAWAII, 30 MINUTES BY AIR FROM HONOLULU). THE ISLAND OF HAWAII SUPPORTS AN AGRICULTURAL-BASED ECONOMY, RANKING FIRST IN MACADAMIA NUT AND COFFEE PRODUCTION IN… more
Abstract:THIS PROJECT IS TO DETERMINE IF CREATIVE AQUACULTURE TECHNIQUES CAN BE APPLIED TO CULTIVATE SEA CUCUMBERS ON A COMMERCIAL SCALE. THREE MAJOR EXPERIMENTS WILL TEST THE NEWTECHNIQUES DESIGNED FOR COMMERCIAL APPLICATION. THE OBJECTIVES ARE: 1) TO INCREASE REPRODUCTIVE EFFICIENCY AND DEVELOP ASSOCIATED… more
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