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State:Hawaii
Company: TECHNICAL RESEARCH ASSOC., INC. Agency/Program/Year/Phase: HHS / SBIR / 1993 / 1
Abstract: Feeding rats a semipurified diet containing casein as a protein source results in severe gastrointestinal (GI) toxicity when the chemotherapeutic drug methotrexate (MTX) is given. However, when soy concentrate protein is used in place of casein, rats are completely protected from toxicity. The… more
Company: TECHNICAL RESEARCH ASSOC., INC. Agency/Program/Year/Phase: NSF / SBIR / 1993 / 1
Abstract: THIS PROJECT IS DEVELOPING A NOVEL SEPARATION TECHNOLOGY BASED ON NEW BULK SEPARATION PARAMETERS. FIELD-FLOW FRACTIONATION (FFF) IS A WELL ESTABLISHED SEPARATION METHOD FOR SEPARATION OF MACROMOLECULES AND PARTICLATES. SEPARATION IS EFFECTED BY THE COMBINED ACTION OF AN APPLIED FIELD FORCE AND A… more
Company: TECHNICAL RESEARCH ASSOC., INC. Agency/Program/Year/Phase: NSF / SBIR / 1993 / 1
Abstract: THIS PROJECT SUGGESTS A NOVEL PROCESSING TECHNIQUE FOR FABRICATING A HIGH-SPEED STEEL COMPOSITE. A HOMOGENEOUS DISPERSION OF NANO-SIZED OXIDE PARTICLES WITHIN THE IRON-BASED MATRIX SUBSTITUTES FOR THE CARBIDE PRECIPITATES IN CURRENT FORMULATIONS, WITHOUT COMPLEX HEAT TREATMENTS AND EXTENSIVE… more
Company: TECHNICAL RESEARCH ASSOC., INC. Agency/Program/Year/Phase: DOD / SBIR / 1993 / 1
Abstract: N/A
Company: TECHNICAL RESEARCH ASSOC., INC. Agency/Program/Year/Phase: DOD / SBIR / 1993 / 1
Abstract: N/A
Company: TECHNICAL RESEARCH ASSOC., INC. Agency/Program/Year/Phase: DOD / SBIR / 1993 / 1
Abstract: N/A
Company: TECHNICAL RESEARCH ASSOC., INC. Agency/Program/Year/Phase: DOD / SBIR / 1993 / 2
Abstract: N/A
Company: HAWAII BIOTECH, INC. Agency/Program/Year/Phase: HHS / SBIR / 1992 / 2
Abstract: PALYTOXIN IS AN EXTREMELY CYTOTOXIC LOW MOLECULAR WEIGHT NATURAL PRODUCT ISOLATED FROM SOFT CORALS OF THE GENUS, PALYTHOA. N-ACYLATED DERIVATIVES OF PALYTOXIN HAVE BEEN REPORTED TO BE UP TO 100-FOLD LESS CYTOTOXIC THAN THE UNMODIFIED TOXIN. PALYTOXIN N-ACYL DERIVATIVES WHICH CAN BE CONVERTED TO THE… more
Company: HAWAII BIOTECH, INC. Agency/Program/Year/Phase: DOD / SBIR / 1992 / 2
Abstract: UREASE OFFERS DISTINCT ADVANTAGES OVER OTHER ENZYMES FOR PREPARATION OF CONJUGATES USED IN ENZYME-LINKED IMMUNO-SORBENT ASSAY SYSTEMS. MOLECULAR DEVICES CORPORATION (MENLO PARK, CA) HAS CAPITALIZED ON THESE ADVANTAGES IN THEIR THRESHOLD SYSTEM. THIS IMPRESSIVE SYSTEM UTILIZES AVIDIN-BIOTIN TO… more
Company: HAWAII BIOTECH, INC. Agency/Program/Year/Phase: NSF / SBIR / 1992 / 1
Abstract: PRODUCTION OF RECOMBINANT PRODUCTS OF PHARMACEUTICAL AND INDUSTRIAL IMPORTANCE IN A VARIETY OF MICROORGANISMS HAS YIELDED A WIDE VARIETY OF BIOLOGICALLY ACTIVE PROTEINS. FUNGI OFFER THE ADVANTAGE OF REDUCED CULTURING AND DOWNSTREAM PROCESSING COSTS BECAUSE THEY ARE CAPABLE OF SECRETING PRODIGIOUS… more
Company: HAWAII BIOTECH, INC. Agency/Program/Year/Phase: HHS / SBIR / 1992 / 1
Abstract: DENGUE VIRUSES ARE A LEADING CAUSE OF MORBIDITY THROUGHOUT THE TROPICS AND SUBTROPICS. ATTEMPTS TO DEVELOP LIVE ATTENUATED DENGUE VACCINES ANALOGOUS TO THE YELLOW FEVER VACINE HAVE BEEN UNSUCCESSFUL. IN AN EFFORT TO CONTRUBITE TO THE DEVELOPMENT OF A RECOMBINANT SUBUNIT DENGUE VACCINE, WE WILL… more
Company: HAWAII BIOTECH, INC. Agency/Program/Year/Phase: HHS / SBIR / 1992 / 1
Abstract: TRANSITION STATE ANALOG HAPTENS WILL BE PREPARED FOR THE ELICITATION OF ANTIBODIES WHICH CAN CATALYZE THE CONVERSION OF PALYTOXIN PRODRUGS TO PALYTOXIN.
Company: HAWAII BIOTECH, INC. Agency/Program/Year/Phase: HHS / SBIR / 1992 / 1
Abstract: WE WILL CONSTRUCT HYBRID POLIO/DENGUE VIRUS GENOMES IN ORDER TO DEVELOP A VACCINE FOR DENGUE VIRUS. IN THE CHIMERIC GENOMES, ONE OF TWO DENGUE VIRUS ENVELOPE GENE FRAGMENTS WILL REPLACE SEGMENT OF THE POLIO VIRUS STRUCTURAL PROTEIN GENES. SUCH CHIMERAE WOULD HAVE THE ABILITY TO REPLICATE IN THE GUT… more
Company: HAWAII BIOTECH, INC. Agency/Program/Year/Phase: HHS / SBIR / 1992 / 1
Abstract: WE WILL ACHIEVE THE SELECTIVE DELIVERY OF CYTOTOXIC AGENTS THROUGH THE USE OF BISPECIFIC ANTIBODIES. TAXOL IS A PROMISING NEW ANTICANCER AGENT ISOLATED IN LOW YIELD FROM THE BARK OF THE PACIFIC YEW TREE, TAXUS BREVIFOLIA. THE APPLICANT WILL PREPARE A THIOETHER-LINKED BISPECIFIC ANTIBODY WITH DIAL… more
Company: HAWAII BIOTECH, INC. Agency/Program/Year/Phase: HHS / SBIR / 1992 / 1
Abstract: HIGH AFFINITY ANTIGEN-ANTIBODY BINDING IS ESSENTIALLY ANHYDROUS HYDROPHOBIC ORGANIC SOLVENTS HAS BEEN DEMONSTRATED IN OUR LABORATORY. USING AN ESTRADIOL-ANTIESTRADIOL SYSTEM, A PROTOTYPE ORGANIC PHASE RADIOIMMUNOASSAY (OPRIA) HAS BEEN DEVELOPED WHICH DETECTS 200 PG/ML OR ESTRADIOL IN A HEXANE MEDIUM… more
Company: HAWAII BIOTECH, INC. Agency/Program/Year/Phase: HHS / SBIR / 1992 / 1
Abstract: A PALYTOXIN PRODURG DERIVATIVE WILL BE PREPARED. THIS COMPOUND WILL BE TESTED FOR ITS DIFFERENTIAL CYTOTOXICITY COMPARED TO PALYTOXIN; AND FOR ITS ABILITY TO BE ENZYMATICALLY ACTIVATED.
Company: Sets Technology Inc Agency/Program/Year/Phase: NASA / SBIR / 1992 / 2
Abstract: THIS PROJECT RESPONDS TO THE NEED FOR AN INFRARED PHOTOMETERTHAT IS CAPABLE OF ACQUIRING, WITH NEAR SIMULTANEITY, DATA IN AT LEAST TWO SELECTABLE PASSBANDS (1.0-TO-5.2 MICRONS AND 8-TO-13 MICRONS). THE PHOTOMETER MUST HAVE HIGH SENSITIVITY, OPERATE WITH A DUTY CYCLE OF ABOUT 100 PERCENT ON-SOURCE… more
Company: Sets Technology Inc Agency/Program/Year/Phase: DOD / SBIR / 1992 / 2
Abstract: THIS PROPOSAL RESPONDS TO TECHNICAL SUBTOPIC A91-021: TOPOGRAPHY, IMAGE INTELLIGENCE, AND SPACE EXPLOITATION, WHICH REQUESTS THAT UNIQUE APPROACHES FOR A REAL TIME KNOWLEDGE ENGINEERING BASED TACTICAL DECISION AIDS SYSTEM BE DEVELOPED INVOLVING PARALLEL COMPUTER ARCHITECTURES. THE OPPORTUNITY IS TO… more
Company: Sets Technology Inc Agency/Program/Year/Phase: NASA / SBIR / 1992 / 2
Abstract: THE GOAL OF THIS PROJECT IS TO PRODUCE AN INSTRUMENT FOR ASTRONOMICAL OBSERVATIONS OF SOLAR SYSTEM OBJECTS IN THE THERMAL INFRARED REGION (5-30MUM), USING AN OPTICAL SYSTEM THAT IS CAPABLE OF RECONSTRUCTING AN IMAGE (WITH MOVABLE APODIZING MASKS) OF ELECTROMAGNETIC RADIATION COLLECTED BY A… more
Company: TECHNICAL RESEARCH ASSOC., INC. Agency/Program/Year/Phase: DOD / SBIR / 1992 / 2
Abstract: THE OBJECTIVES OF THIS PHASE I EFFORT ARE: I. STUDY EUTECTIC COMBINATIONS OF HYDROXYLAMMONIUM PERCHLORATE AND OTHER OXIDIZERS. A. DEVELOP THE PHASE DIAGRAM OF HAP AND AMMONIUM PERCHLORATE. B. DEVELOP THE PHASE DIAGRAM OF HAP AND POTASSIUM PERCHLORATE. II. STUDY THE EFFECTS OF MONOETHANOLAMINE… more
Company: TECHNICAL RESEARCH ASSOC., INC. Agency/Program/Year/Phase: HHS / SBIR / 1992 / 2
Abstract: THE OVERALL OBJECTIVE OF THIS PROJECT IS TO DESIGN, DEVELOP, AND CONSTRUCT A BONE MARROW SEPARATION DEVICE THAT WILL OFFER SIGNIFICANTLY SUPERIOR PERFORMANCE COMPARED WITH CURRENT METHODS OF VELOCITY SEDIMENTATION. IN PHASE I, TECHNICAL RESEARCH ASSOCIATES, INC. (TRA) WILL APPLY PATENTED… more
Company: TECHNICAL RESEARCH ASSOC., INC. Agency/Program/Year/Phase: DOD / SBIR / 1992 / 2
Abstract: TRA PROPOSES TO DEVELOP, CONSTRUCT, AND PRODUCE A SMALL (130 IN [3]) LIGHTWEIGHT (2-3 LBS) MULTIPURPOSE MEDICAL CENTRIFUGE FOR COMBAT CASUALTY CARE UNITS. THE CENTRIFUGE WILL BE POWERED BY EITHER 110-220 VAC, 50-60 HZ OR BATTERIES AND WILL BE DESIGNED AND TESTED TO OPERATE IN EXTREME TEMPERATURE,… more
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