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Displaying 476 – 500 of 636 Awards
Company: HAWAII BIOTECH, INC. Agency/Program/Year/Phase: NSF / SBIR / 1993 / 1
Abstract: THE DEVELOPMENT OF MICROBIAL SYSTEMS FOR EXPRESSION OF HETEROLOGOUS PROTEINS HAS ENABLED THE ISOLATION OF GREATER AMOUNTS OF SOURCE PROTEINS, OFTEN IN GREATER PURITY THAN IS POSIBLE FROM THE ORIGINAL SOURCE. PROTEINS SO EXPRESSED HAVE APPLICATIONS RANGING FROM INDUSTRIAL USE, THROUGH PROTEIN… more
Company: HAWAII BIOTECH, INC. Agency/Program/Year/Phase: HHS / SBIR / 1993 / 1
Abstract: Regulation of gene expression is critical for cellular and organismal development, and it often plays an important role in expression of heterologous recombinant proteins. Toward development of regulated expression vectors for filamentous fungi that will minimize materials cost and manipulation of… more
Company: HAWAII BIOTECH, INC. Agency/Program/Year/Phase: HHS / SBIR / 1993 / 1
Abstract: The filamentous fungi, owing to their ability to secrete high levels of proteins, are attractive organisms for the expression and secretion of heterologous proteins of commercial and medical value. Secretion is a key element in their attraction; secretion provides the opportunity for complex… more
Company: Hawaii Fish Company Agency/Program/Year/Phase: USDA / SBIR / 1993 / 1
Abstract: THE STRIPED SNAKEHEAD CHANNA STRIATUS IS A HIGHLY ESTEEMED FOODFISH IN SOUTHEAST AND SOUTH ASIA. MILLIONS OF FISH ARE CONSUMED ANNUALLY IN COUNTRIES OF THIS REGION. SEVERAL THOUSAND METRIC TONS OF FROZEN WHOLE SNAKEHEAD ARE ALSO IMPORTED ANNUALLY INTO NORTH AMERICA FOR SALE IN DOMESTIC ASIAN SEAFOOD… more
Company: Kona Cinder & Soil Agency/Program/Year/Phase: USDA / SBIR / 1993 / 1
Abstract: KONA CINDER & SPOILS, INC. IS A SMALL-BUSINESS INVOLVED IN THE AGRICULTURAL/LANDSCAPE SOIL BUSINESS IN KONA, WEST HAWAII (ON THE ISLAND OF HAWAII, 30 MINUTES BY AIR FROM HONOLULU). THE ISLAND OF HAWAII SUPPORTS AN AGRICULTURAL-BASED ECONOMY, RANKING FIRST IN MACADAMIA NUT AND COFFEE PRODUCTION IN… more
Company: Royal Hawaiian Sea Farms Inc. Agency/Program/Year/Phase: USDA / SBIR / 1993 / 2
Abstract: THIS PROJECT IS TO DETERMINE IF CREATIVE AQUACULTURE TECHNIQUES CAN BE APPLIED TO CULTIVATE SEA CUCUMBERS ON A COMMERCIAL SCALE. THREE MAJOR EXPERIMENTS WILL TEST THE NEWTECHNIQUES DESIGNED FOR COMMERCIAL APPLICATION. THE OBJECTIVES ARE: 1) TO INCREASE REPRODUCTIVE EFFICIENCY AND DEVELOP ASSOCIATED… more
Company: Synthetic Technology Agency/Program/Year/Phase: HHS / SBIR / 1993 / 1
Abstract: N/A
Company: TECHNICAL RESEARCH ASSOC., INC. Agency/Program/Year/Phase: DOD / SBIR / 1993 / 2
Abstract: THE OVERALL OBJECTIVE OF THIS PROJECT IS TO INTEGRATE TERFENOL-D INTO NEW ACTUATOR DESIGNS APPLICABLE TO DEXTEROUS EXOSKELETAL FEEDBACK SYSTEMS FOR TELEROBOTIC APPLICATIONS. THE DEVELOPMENT OF NEW EFFICIENT, RESPONSIVE, SMALL, LIGHTWEIGHT ACTUATORS IS CRITICAL TO THE ACHIEVEMENT OF SENSORY FEEDBACK… more
Company: TECHNICAL RESEARCH ASSOC., INC. Agency/Program/Year/Phase: DOD / SBIR / 1993 / 2
Abstract: THERMOSET RESIN IMPREGNATED YARNS, FABRICS AND TAPES (PREPREGS) COMPRISE A SIGNIFICANT FRACTION OF THE MATERIALS USED IN THE FABRICATION OF CURRENT AND DEVELOPING AIR FORCE AIRCRAFT SYSTEMS. TWO PROBLEMS EXIST, HOWEVER, WITH THE PREPREG MATERIALS. THESE MATERIALS HAVE ONLY A SIX-MONTH SHELF LIFE AND… more
Company: TECHNICAL RESEARCH ASSOC., INC. Agency/Program/Year/Phase: HHS / SBIR / 1993 / 1
Abstract: Feeding rats a semipurified diet containing casein as a protein source results in severe gastrointestinal (GI) toxicity when the chemotherapeutic drug methotrexate (MTX) is given. However, when soy concentrate protein is used in place of casein, rats are completely protected from toxicity. The… more
Company: TECHNICAL RESEARCH ASSOC., INC. Agency/Program/Year/Phase: NSF / SBIR / 1993 / 1
Abstract: THIS PROJECT IS DEVELOPING A NOVEL SEPARATION TECHNOLOGY BASED ON NEW BULK SEPARATION PARAMETERS. FIELD-FLOW FRACTIONATION (FFF) IS A WELL ESTABLISHED SEPARATION METHOD FOR SEPARATION OF MACROMOLECULES AND PARTICLATES. SEPARATION IS EFFECTED BY THE COMBINED ACTION OF AN APPLIED FIELD FORCE AND A… more
Company: TECHNICAL RESEARCH ASSOC., INC. Agency/Program/Year/Phase: NSF / SBIR / 1993 / 1
Abstract: THIS PROJECT SUGGESTS A NOVEL PROCESSING TECHNIQUE FOR FABRICATING A HIGH-SPEED STEEL COMPOSITE. A HOMOGENEOUS DISPERSION OF NANO-SIZED OXIDE PARTICLES WITHIN THE IRON-BASED MATRIX SUBSTITUTES FOR THE CARBIDE PRECIPITATES IN CURRENT FORMULATIONS, WITHOUT COMPLEX HEAT TREATMENTS AND EXTENSIVE… more
Company: TECHNICAL RESEARCH ASSOC., INC. Agency/Program/Year/Phase: DOD / SBIR / 1993 / 1
Abstract: N/A
Company: TECHNICAL RESEARCH ASSOC., INC. Agency/Program/Year/Phase: DOD / SBIR / 1993 / 2
Abstract: N/A
Company: HAWAII BIOTECH, INC. Agency/Program/Year/Phase: HHS / SBIR / 1992 / 2
Abstract: PALYTOXIN IS AN EXTREMELY CYTOTOXIC LOW MOLECULAR WEIGHT NATURAL PRODUCT ISOLATED FROM SOFT CORALS OF THE GENUS, PALYTHOA. N-ACYLATED DERIVATIVES OF PALYTOXIN HAVE BEEN REPORTED TO BE UP TO 100-FOLD LESS CYTOTOXIC THAN THE UNMODIFIED TOXIN. PALYTOXIN N-ACYL DERIVATIVES WHICH CAN BE CONVERTED TO THE… more
Company: HAWAII BIOTECH, INC. Agency/Program/Year/Phase: DOD / SBIR / 1992 / 2
Abstract: UREASE OFFERS DISTINCT ADVANTAGES OVER OTHER ENZYMES FOR PREPARATION OF CONJUGATES USED IN ENZYME-LINKED IMMUNO-SORBENT ASSAY SYSTEMS. MOLECULAR DEVICES CORPORATION (MENLO PARK, CA) HAS CAPITALIZED ON THESE ADVANTAGES IN THEIR THRESHOLD SYSTEM. THIS IMPRESSIVE SYSTEM UTILIZES AVIDIN-BIOTIN TO… more
Company: HAWAII BIOTECH, INC. Agency/Program/Year/Phase: NSF / SBIR / 1992 / 1
Abstract: PRODUCTION OF RECOMBINANT PRODUCTS OF PHARMACEUTICAL AND INDUSTRIAL IMPORTANCE IN A VARIETY OF MICROORGANISMS HAS YIELDED A WIDE VARIETY OF BIOLOGICALLY ACTIVE PROTEINS. FUNGI OFFER THE ADVANTAGE OF REDUCED CULTURING AND DOWNSTREAM PROCESSING COSTS BECAUSE THEY ARE CAPABLE OF SECRETING PRODIGIOUS… more
Company: HAWAII BIOTECH, INC. Agency/Program/Year/Phase: HHS / SBIR / 1992 / 1
Abstract: DENGUE VIRUSES ARE A LEADING CAUSE OF MORBIDITY THROUGHOUT THE TROPICS AND SUBTROPICS. ATTEMPTS TO DEVELOP LIVE ATTENUATED DENGUE VACCINES ANALOGOUS TO THE YELLOW FEVER VACINE HAVE BEEN UNSUCCESSFUL. IN AN EFFORT TO CONTRUBITE TO THE DEVELOPMENT OF A RECOMBINANT SUBUNIT DENGUE VACCINE, WE WILL… more
Company: HAWAII BIOTECH, INC. Agency/Program/Year/Phase: HHS / SBIR / 1992 / 1
Abstract: TRANSITION STATE ANALOG HAPTENS WILL BE PREPARED FOR THE ELICITATION OF ANTIBODIES WHICH CAN CATALYZE THE CONVERSION OF PALYTOXIN PRODRUGS TO PALYTOXIN.
Company: HAWAII BIOTECH, INC. Agency/Program/Year/Phase: HHS / SBIR / 1992 / 1
Abstract: WE WILL CONSTRUCT HYBRID POLIO/DENGUE VIRUS GENOMES IN ORDER TO DEVELOP A VACCINE FOR DENGUE VIRUS. IN THE CHIMERIC GENOMES, ONE OF TWO DENGUE VIRUS ENVELOPE GENE FRAGMENTS WILL REPLACE SEGMENT OF THE POLIO VIRUS STRUCTURAL PROTEIN GENES. SUCH CHIMERAE WOULD HAVE THE ABILITY TO REPLICATE IN THE GUT… more
Company: HAWAII BIOTECH, INC. Agency/Program/Year/Phase: HHS / SBIR / 1992 / 1
Abstract: WE WILL ACHIEVE THE SELECTIVE DELIVERY OF CYTOTOXIC AGENTS THROUGH THE USE OF BISPECIFIC ANTIBODIES. TAXOL IS A PROMISING NEW ANTICANCER AGENT ISOLATED IN LOW YIELD FROM THE BARK OF THE PACIFIC YEW TREE, TAXUS BREVIFOLIA. THE APPLICANT WILL PREPARE A THIOETHER-LINKED BISPECIFIC ANTIBODY WITH DIAL… more
Displaying 476 – 500 of 636 Awards
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