Abstract:DESCRIPTION (provided by applicant): Ataxia-telangiectasia (A-T) is a multi-systemic, recessively inherited disorder that affects between 1 in 40,000 to 1 in 100,000 individuals worldwide. It is characterized primarily by early onset cerebellar ataxia andtelangiectasia, from which the disease name… more
Abstract:Project Summary/Abstract Cancer is the second deadliest disease in the United States, killing more than 500,000 Americans annually. This year, another 1.5 million will be diagnosed with one of nearly 200 different cancer types. Despite an ever---growing understanding of the environmental risk… more
Abstract:DESCRIPTION (provided by applicant): Aortic aneurysms and dissections are a cause of frequently preventable death for over 13,000 people annually in the US alone. Many more patients live under a constant threat of a catastrophic aortic event from atherosclerotic or congenital causes. Therefore,… more
Abstract:ASW training requires an accurate simulation of both sonobuoy data content and geolocation in order to maintain peak crew proficiency. Unfortunately, existing systems can generate and emit the necessary field of 64 sonobuoy signal simulations, but without the geographic dispersion of a real sonobuoy… more
Abstract:During initial design studies, parametric variation of vehicle geometryis routine. In addition, rotorcraft engineers traditionally use the wind tunnel to evaluate and finalize designs. Correlation between wind tunnel results and flight tests, when not good, have been often attributed in part to… more
Abstract:In this highly interconnected world, transportation systems must feature increased flexibility and shorter door-to-door trip times to be successful. Shorter door-to-door trip times require an increased usage of rotary wing and runway independent V/STOL technology. One of the limiting factors to… more
Abstract:Human Campylobacter disease caused by the foodborne pathogens, Campylobacter jejuni and Campylobacter coli, is a huge public health problem globally. The economic burden of this disease, which ranges from mild self-limiting diarrhea to devastating neurological complications, in the United States… more
Abstract:Rural communities, comprised of both residential and commercial buildings, are struggling to maintain their populations and the vitality of their downtown districts and schools. They are spending significant dollars on energy bills and wasting as much as 25% of that energy. Buildings accounted for… more
Abstract:DESCRIPTION (provided by applicant): Alzheimer's disease afflicts an estimated 5.1 million people in the United States, and as life expectancies increase it is anticipated that this number will continue to rise (Institute of Medicine, 2008). Besides the personal toll on the patients and their… more
Abstract:The development of complex aviation weapons systems involves flight testing at various stages of the design cycle. Test pilots are highly trained individuals with flight and assessment skills necessary to evaluate the performance of test articles. Test pilots might subconsciously use their high… more
Abstract:As the focus on survivability, injury prevention, armor design, and human centric design increases, more attention must be paid to human modeling, especially with regards to the head and neck, not only for protection against ballistics and impact, but also for biomechanical issues as a result of… more
Abstract:This Small Business Innovation Research (SBIR) Phase II project will further develop a fully hardened, user friendly ASL Pichia monitor for commercial protein production. The Phase I effort demonstrated the commercial feasibility of the continuous, real-time near infrared monitor for tracking… more
Abstract:This application addresses the USDA NIFA "Global Food Security and Hunger" primary societal challenge area by developing a countermeasure against a potential agricultural disease threat - Rift Valley fever virus (RVFV). RVFV is an arthropod-borne pathogen that often results in severe… more
Abstract:Development of an energy harvesting system utilizing the magnetostrictive material, Galfenol, will be completed in this effort. The energy harvesting system will consist of Galfenol plates or sheets, magnetic circuit components, coupling structure, power conditioning electronics, sensor, and… more
Abstract:Etrema proposes to develop a modified acoustic projector design that provides broad bandwidth, high source level, directional output, high duty cycle, and high reliability in a compact package. The design will target the same acoustic source levels as the baseline Vector Projector with higher duty… more
Abstract:Etrema proposes to develop a free-flooded Galfenol split-ring transducer that will provide 50-75 Hz of bandwidth on a 200 Hz carrier wave capable of operating at depths up to 1000 m with a source level greater than 190 dB re 1uPa @ 1m. While there are no specifications on size, the desire expressed… more
Abstract:Etrema is developing an acoustic projector that provides broad bandwidth, high source level, directional output, high duty cycle, and high reliability in a compact package. Specific objectives of the Phase II effort are: demonstrate performance of a prototype projector, optimize the full-scale… more
Abstract:DESCRIPTION (provided by applicant): Project Summary/Abstract Duchenne muscular dystrophy (DMD) is an X-linked recessive disorder caused by mutations in the DMD gene with a prevalence of 1 in 3500 male births. The consequent loss of functional dystrophin results in the progressive degeneration… more
Abstract:DESCRIPTION (provided by applicant): Ataxia-Telangiectasia (A-T) is a multi-systemic, recessively inherited disorder characterized primarily by early onset cerebellar ataxia and telangiectasia, from which the disease name is derived. In addition, patientsalso exhibit a number of other clinical… more
Abstract:DESCRIPTION (provided by applicant): Atherosclerosis is the primary cause of cardiovascular disease, which is the most common cause of death in the United States. Atherosclerosis is characterized by the accumulation of lipids, cholesterol, calcium deposits, and cellular debris in vessel walls, and… more
Abstract:Currently there are no truly effective interventions or therapeutic treatments for White spot syndrome virus (WSSV) in farmed shrimp. Current production practices focus on pathogen exclusion by stocking specific pathogen free (SPF) larvae, decontamination and filtration of water to prevent pathogen… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project is about developing an Educational Interactive Hemodynamics Flow Visualization and Analysis System to be used in physiology courses for anyone studying blood flows such as medical or bioengineering students. Study of hemodynamics is very… more
Abstract:The incorporation of viscous analysis in design is vital for a completeunderstanding of aerodynamic problems.This proposal offers to develop and integrate with RotCFD a method for semi-automatically generating grids suitable for viscous
analysis on complex configurations as well as parallelize the… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project aims to use nitrocarburizing plasmas to generate nanostructured layer on top of nitride case on cast iron surfaces of cast iron dies used in the stamping of high-strength-steel sheets. To deposit nanostructured coatings, reactive… more
Abstract:DESCRIPTION (provided by applicant): In approximately 30% of epileptic patients, seizures are not controlled by currently available therapeutic agents. Even though a number of new chemical entities have entered the marketplace, therapy resistant seizures remain. This project is innovative in that… more
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