Abstract:The proposed effort will design and build a 64 channel ASW test/training system that relays individual sonobuoy acoustic data from a master scenario generator to each randomly located/drifting relay sonobuoy. The data is retransmitted as simulated sonobuoy data for purposes of training and testing.… more
Abstract:There is a manifest need in the US and the world for renewable, lowcost energy. However, conventional and small hydropower systems for (20,000+) low head dams (550ft.) in the US tend to be extremely costintensive due to a variety of configurational issues. These include coffer dams, power houses,… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project involves the development of the Design environment for Aerospace Vehicles in Classroom Interaction (DAVinCI). DAVinCI is a collaborative, guided inquiry environment and game targeted for grades 9-12. This concept will integrate aerospace… more
Abstract:DESCRIPTION (provided by applicant): HIV-associated neurocognitive disorders (HAND) remain prevalent despite effective anti-retroviral treatments. Cognitive impairments in the current treatment era are often mild and not readily detectable because currentscreening measures (e.g., the HIV Dementia… more
Abstract:DESCRIPTION (provided by applicant): Juvenile neuronal ceroid lipofuscinosis (JNCL), also known as Batten disease, is an autosomal recessive disorder caused by mutations in the CLN3 gene with a worldwide incidence of 1 in 12,500 live births. It is part ofa group of lysosomal storage disorders - the… more
Abstract:Aortic aneurysms and dissections are a cause of frequently preventable death for over 13,000 people annually in the US alone. Many more patients live under a constant threat of a catastrophic aortic event from atheroscle- rotic or congenital causes. Therefore, early and comprehensive diagnosis of… more
Abstract:Softronics Ltd. proposes employing a novel circuit topology to create a state-of-the-art replacement for the emergency buoy HF transmitter. Using less than 24 components per transmitter, it features very high power efficiency and extended battery life. The 5 cubic inch, 3 ounce transmitter module is… more
Abstract:ABSTRACT: Softronics Ltd. proposes to implement an advanced VLF receiver front end utilizing a trio of advanced technologies. The first is a digital cancellation DSP technique that reduces both atmospheric noise and jamming signals within the desired passband, significantly improving the SNR of… more
Abstract:DESCRIPTION (provided by applicant): The goal of these studies is to determine the efficacy of proprietary geranylgeranyl diphosphate synthase inhibitors (GGSIs), for inhibition of osteoclast mediated bone resorption in comparison to current standard-of-care agents. We have developed a group of… more
Abstract:DESCRIPTION (provided by applicant): Acute kidney injury (AKI) affects more than 10 million people worldwide each year with reported mortalities from 15 to 60% in different patient populations. However, methods are lacking to support the early diagnosis ofAKI that could lead to early intervention,… more
Abstract:This Small Business Technology Transfer (STTR) Phase I project proposes to develop and commercialize a new scalable manufacturing capability that will produce bio-based chemicals for surfactants, lubricants, and polymers. At the core of this new manufacturing platform is a re-designed microorganism… more
Abstract:The objective of this proposal is to demonstrate a new method that will make possible the treatment of large-scale problems with current computational resources. The idea behind the proposed technique is the use of analytical rotated overset grids to define the geometry. Instead of exactly fitting… more
Abstract:The innovation proposed is to develop a video game for elementary school teachers and students using inquiry-based learning to demonstrate interdependencies in ecological systems. High-quality science teaching tools are needed because the US is ranked 17th in science education among developed… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project aims to evaluate the use of a marine organism for production of the polyunsaturated fatty acid (PUFA), docosahexaenoic acid (DHA). DHA is important for maintaining good health and is in serious supply shortage worldwide. Metabolic… more
Abstract:DESCRIPTION (provided by applicant): Heavy alcohol use is common and presents a major social/economic challenge. Although chronic use of small amounts of alcohol is not always harmful, heavier use (gt2 drinks/day) is generally harmful and frequently leadsto alcoholism-the most common forms being… more
Abstract:DESCRIPTION (provided by applicant): Aging-induced skeletal muscle atrophy, also known as sarcopenia, affects approximately 30 million people in the United States, often leading to weakness, reduced quality-of-life, falls, fractures, debilitation, insulinresistance, prolonged hospitalizations and… more
Abstract:Identification and Significance of the Problem: The United States alone has over 80,000 dams, unused for power generation. The cost of installing conventional hydro power generation equipment would be high and uneconomical. DOE research confirms that at least 165,000MW of untapped hydroelectric… more
Abstract:DESCRIPTION (provided by applicant): There is a tremendous need for tools that allow NIH sponsored investigators to easily share and disseminate data from brain imaging studies. Access to large neuroimaging data sets is a critical aspect of learning abouthow the brain works both in health and… more
Abstract:In November 2011 the worlds human population reached 7 billion. Concurrent role shifts in world economies (e.g., competition for seafood products with China) make it necessary for aquaculture to grow at a pace much faster than previously estimated. In addition, the American seafood trade deficit now… more
Abstract:This STTR is aimed at developing methods and tools to characterize the impact of free-play on control surface flutter and overall stability and performance of the system. A successful completion of this two-phased STTR effort will lead to a modeling, analysis, design, and simulation tool that will… more
Abstract:DESCRIPTION (provided by applicant): Chemotherapy drugs tend to be highly cytotoxic and genotoxic, with well-documented carcinogenic, mutagenic, and teratogenic effects. Long-term occupational exposure to these highly toxic drugs presents serious health risks (e.g., cancers, infertility,… more
Abstract:This effort will develop a comprehensive, validated toolkit to aid product designers and Government procurement personnel in evaluating alternative designs for head-borne equipment. In the first phase of this project, Viz-Tek, Inc. completed an initial concept for an advanced head-neck model that… more
Abstract:This Small Business Innovation Research Phase I project will develop a fiber optically coupled in situ probe utilizing a superluminescent diode (SLD) optical source for monitoring bioreactor fermentations with ASL?s bioreactor monitor. The current ASL monitor uses a conventional, thermal light… more
Abstract:DESCRIPTION (provided by applicant): Ataxia-telangiectasia (A-T) is a multi-systemic, recessively inherited disorder that affects between 1 in 40,000 to 1 in 100,000 individuals worldwide. It is characterized primarily by early onset cerebellar ataxia andtelangiectasia, from which the disease name… more
Abstract:Project Summary/Abstract Cancer is the second deadliest disease in the United States, killing more than 500,000 Americans annually. This year, another 1.5 million will be diagnosed with one of nearly 200 different cancer types. Despite an ever---growing understanding of the environmental risk… more
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