Abstract:DESCRIPTION (provided by applicant): Alzheimer's disease afflicts an estimated 5.1 million people in the United States, and as life expectancies increase it is anticipated that this number will continue to rise (Institute of Medicine, 2008). Besides the personal toll on the patients and their… more
Abstract:The development of complex aviation weapons systems involves flight testing at various stages of the design cycle. Test pilots are highly trained individuals with flight and assessment skills necessary to evaluate the performance of test articles. Test pilots might subconsciously use their high… more
Abstract:As the focus on survivability, injury prevention, armor design, and human centric design increases, more attention must be paid to human modeling, especially with regards to the head and neck, not only for protection against ballistics and impact, but also for biomechanical issues as a result of… more
Abstract:This Small Business Innovation Research (SBIR) Phase II project will further develop a fully hardened, user friendly ASL Pichia monitor for commercial protein production. The Phase I effort demonstrated the commercial feasibility of the continuous, real-time near infrared monitor for tracking… more
Abstract:This application addresses the USDA NIFA "Global Food Security and Hunger" primary societal challenge area by developing a countermeasure against a potential agricultural disease threat - Rift Valley fever virus (RVFV). RVFV is an arthropod-borne pathogen that often results in severe… more
Abstract:Development of an energy harvesting system utilizing the magnetostrictive material, Galfenol, will be completed in this effort. The energy harvesting system will consist of Galfenol plates or sheets, magnetic circuit components, coupling structure, power conditioning electronics, sensor, and… more
Abstract:Etrema proposes to develop a modified acoustic projector design that provides broad bandwidth, high source level, directional output, high duty cycle, and high reliability in a compact package. The design will target the same acoustic source levels as the baseline Vector Projector with higher duty… more
Abstract:Etrema proposes to develop a free-flooded Galfenol split-ring transducer that will provide 50-75 Hz of bandwidth on a 200 Hz carrier wave capable of operating at depths up to 1000 m with a source level greater than 190 dB re 1uPa @ 1m. While there are no specifications on size, the desire expressed… more
Abstract:Etrema is developing an acoustic projector that provides broad bandwidth, high source level, directional output, high duty cycle, and high reliability in a compact package. Specific objectives of the Phase II effort are: demonstrate performance of a prototype projector, optimize the full-scale… more
Abstract:DESCRIPTION (provided by applicant): Project Summary/Abstract Duchenne muscular dystrophy (DMD) is an X-linked recessive disorder caused by mutations in the DMD gene with a prevalence of 1 in 3500 male births. The consequent loss of functional dystrophin results in the progressive degeneration… more
Abstract:DESCRIPTION (provided by applicant): Ataxia-Telangiectasia (A-T) is a multi-systemic, recessively inherited disorder characterized primarily by early onset cerebellar ataxia and telangiectasia, from which the disease name is derived. In addition, patientsalso exhibit a number of other clinical… more
Abstract:DESCRIPTION (provided by applicant): Atherosclerosis is the primary cause of cardiovascular disease, which is the most common cause of death in the United States. Atherosclerosis is characterized by the accumulation of lipids, cholesterol, calcium deposits, and cellular debris in vessel walls, and… more
Abstract:Currently there are no truly effective interventions or therapeutic treatments for White spot syndrome virus (WSSV) in farmed shrimp. Current production practices focus on pathogen exclusion by stocking specific pathogen free (SPF) larvae, decontamination and filtration of water to prevent pathogen… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project is about developing an Educational Interactive Hemodynamics Flow Visualization and Analysis System to be used in physiology courses for anyone studying blood flows such as medical or bioengineering students. Study of hemodynamics is very… more
Abstract:The incorporation of viscous analysis in design is vital for a completeunderstanding of aerodynamic problems.This proposal offers to develop and integrate with RotCFD a method for semi-automatically generating grids suitable for viscous
analysis on complex configurations as well as parallelize the… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project aims to use nitrocarburizing plasmas to generate nanostructured layer on top of nitride case on cast iron surfaces of cast iron dies used in the stamping of high-strength-steel sheets. To deposit nanostructured coatings, reactive… more
Abstract:DESCRIPTION (provided by applicant): In approximately 30% of epileptic patients, seizures are not controlled by currently available therapeutic agents. Even though a number of new chemical entities have entered the marketplace, therapy resistant seizures remain. This project is innovative in that… more
Abstract:The aerodynamic performance of aircraft is significantly impacted by the aero-elastic dynamics of its control surfaces. In particular, the dynamics of flutter - an unstable self-excitation of structure due to undesirable coupling of structural flexibility and aerodynamics - has critical impact on… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project will test the baseline requirements necessary for the development of an employee performance measurement platform that utilizes technology to accomplish a continuous service performance data flow used to motivate employees to higher… more
Abstract:The Smart Grid opens the door to the development of many companion devices which will in turn enable the development of a variety of devices for household electricity-consuming appliances that can communicate with it; especially, many major appliance manufacturers (such as Whirlpool and General… more
Abstract:DESCRIPTION (provided by applicant): Drugs used for cancer chemotherapy tend to be highly cytotoxic and genotoxic, with well-documented carcinogenic, mutagenic, and teratogenic effects. Long-term, occupational exposure to these highly toxic drugs presents
serious health risks to the healthcare… more
Abstract:This SBIR Phase I project will develop the feasibility of using piezoelectric transducers to create an artificial plant, embodied as tall bunchgrass, that will harvest and store energy from wind. This device will have aesthetic appeal and provide a nonpolluting supplement to energy produced by wind… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project aims to demonstrate a unique and affordable method to nanotexture the surfaces of metal platform drug-eluting stents (DES) using ultrafast laser surface modification. This technology is relatively inexpensive and capable of integrating… more
Abstract:The SKATE concept was designed to quantify skill levels of trainees, teams, or units, generate skill-appropriate training scenarios, and provide a continuous skill-level assessment of disparately skilled trainees, teams, and units in a joint training exercise while maintaining the overall integrity… more
Abstract:This proposal describes an approach to realize InAs/GaSb type II superlattice focal plane arrays through planar processing. A problem with conventional mesa diode processing approaches is that nonradiative surface recombination at the exposed pn junction is extremely rapid, leading to surface… more
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