Abstract:DESCRIPTION (provided by applicant): Cystic fibrosis (CF) is caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. The CFTR gene encodes a chloride channel that regulates ion flow across epithelial cell membranes. Most
CF patients have a mutation that deletes… more
Abstract:This Small Business Innovation Research Phase 1 project develops a technology by which diesel fuel consumption can be significantly reduced while increasing productivity in recovering woody biomass. Diesel fuel is the number one operating cost of an industrial grinder and it is estimated that the… more
Abstract:Commercial soybeans require heat processing to deactivate anti-nutrition factors/enzymes. Schillinger Seed has developed a new soybean free of the key anti-nutrition Kunitz Tyrpsin Inhibitor (SKTI-Null). This new SKTI-Null) soybean presents the opportunity for ambient or cold processing of soybeans… more
Abstract:DESCRIPTION (provided by applicant): Our understanding of complex biological phenomena and disease progression has led to the realization that changes in the expression of genes underlie many of these processes. Developing reagents that can selectively al
ter the expression level of any desired… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project is to develop a low cost educational particle image velocimetry (PIV) suite including both hardware and software for fluid science and engineering education at high-school, undergraduate and graduate school levels. PIV technology is… more
Abstract:This Phase I SBIR project develops a novel technology to help plants defend themselves against aphid attack. The currently available insecticidal control methods have the risks of killing beneficial insects and polluting the environment. Plants are capable of using aphid-induced volatile signals for… more
Abstract:DESCRIPTION (provided by applicant): Humans develop natural antibodies against a sugar molecule called Gal, which is present on proteins and lipids in most other species. These antibodies represent one of the strongest natural barriers to infection with ba
cteria, parasites and viruses. NewLink… more
Abstract:This SBIR Phase I project aims to develop a novel surface modification technology for aluminum alloys used in automotive internal combustion engines to improve resistance to friction. The related energy loss due to wear of components directly impacts the fuel efficiency of the automobile. The… more
Abstract:DESCRIPTION (provided by applicant): Parkinson's disease (PD) is a debilitating neurodegenerative disorder characterized by progressive and substantial loss of dopaminergic neurons in the substantia nigra compacta (SNc), resulting in severe neurological si
gns including tremors, bradykinesia, and… more
Abstract:Rotorcraft engineers traditionally use the wind tunnel to evaluate and
finalize designs. Insufficient correlation between wind tunnel results and flight tests,
have been often attributed in part to uncertainty in blockage corrections.
Estimation of rotor blockage is significantly more complex than… more
Abstract:The lack of proper estimation of air loads encountered during transient maneuvers introduces excessive design conservatism. A reduced fidelity CFD methodology based on momentum source (Rot3DC) and a comprehensive analysis code (RCAS) were coupled in Phase I to validate the ''proof-of-concept'' that… more
Abstract:Homologous recombination (HR) permits the precise insertion, deletion, or substitution of genetic material in the genome of an organism. HR offers numerous opportunities for modifying plant genomes to enhance our understanding of plant gene function and regulation, especially with respect to… more
Abstract:We propose to use physiological sensors to measure the quality of a trainee's interaction with a virtual environment (VE) as a function of VE fidelity to enable design improvements in VEs and to enhance training effectiveness through feedback of physiological-based performance information. Currently… more
Abstract:DESCRIPTION (provided by applicant): A collaborative effort between ASL Analytical, Inc. and a research team at the University of Iowa is proposed to development a noninvasive nocturnal hypoglycemic alarm. The goal for the alarm system is to provide con
tinuous noninvasive measurements during the… more
Abstract:Consumers and an ever growing segment of the pork industry know that more optimal levels of
marbling must be put back into the high-value pork cuts. Biotronics, Inc. is developing
technology to solve this problem by using real-time ultrasound to measure the percent of
intramuscular (% IMF) fat in… more
Abstract:The proposed development will result in a compact, efficient, broadband transducer module including amplifier and wet-end transducer. To facilitate multiple mission requirements, the transducer performance goals are a broad bandwidth (7-30 kHz), compact size on the order of 1/2 wavelength at the… more
Abstract:Current ASW missions require low frequency off-board sound sources that can operate monostatically or bistatically. Since these sources may or may not be recoverable, and may require a substantial number to cover the designated operating areas, the low frequency source transducers also need to be… more
Abstract:The size of conventional split ring transducers is much smaller than a wavelength at operating frequency leading to a high Q resonance and limited operating bandwidth. The proposed work will investigate two different modifications to the split ring structure that allow its resonance frequency to be… more
Abstract:"This proposal, lead by Frontline BioEnergy, teams with the Iowa State University (ISU),
Center for Sustainable Energy Technologies (CSET) to develop high quality, time-stable
and storable fast pyrolysis oils in phase-I that are useful for production of fungible liquid
fuels such as diesel, gasoline… more
Abstract:There is a clear and immediate need for improved PRRSV vaccines. PRRS is estimated to cost pork producers in the U.S. nearly $600 million annually and with a national eradication effort being proposed, the need for a second generation vaccine tool that is effective and safe is crucial. The use of a… more
Abstract:DESCRIPTION (provided by applicant): Synthetic DNA and RNA oligomers are important tools for biological and medical assays including polymerase chain reactions, sequencing, DNA microarrays, antisense technology and RNA interference. Oligomers are generally
used in experiments where they anneal to… more
Abstract:This SBIR Phase II project aims to develop and commercialize a novel, next-generation photoluminescence (PL)-based, palm-size and miniaturizable dissolved oxygen (DO) sensor. DO sensors are primary monitors of water quality in industrial wastewater treatment. The new sensor is based on a pioneering… more
Abstract:This Small Business Technology Transfer (STTR) Phase I project aims to develop a novel chemistry to prepare metal fluorides by the direct reaction of metals with fluorocarbons. The new process is highly suited to the manufacture of: (1) wires for optical communications; (2) high-surface-area metal… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project will develop nanolaminate Nd-Fe-B permanent magnets that will increase their operating temperatures, potentially expanding their applications in automobiles and others. An advanced yet affordable excimer laser surface modification method… more
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