Abstract:DESCRIPTION (provided by applicant): Indolamine 2,3-deoxygenase enzymes (IDO-1 and IDO-2) play important counter-regulatory roles in the immune system. IDO-mediated tryptophan catabolism induces T cell suppression, which plays a physiological role in suppr
essing autoimmune and allergic diseases, as… more
Abstract:During initial design studies, parametric variation of vehicle geometry
is routine. In addition, rotorcraft engineers traditionally use the wind tunnel to evaluate and finalize designs. Estimation of rotor tunnel
blockage is significantly more complex than bluff body corrections as the correction… more
Abstract:DESCRIPTION (provided by applicant): The goal of these studies is the development of a treatment for hormone refractory prostate cancer based on the inhibition of an enzyme geranygeranyl disphosphate synthase (GGDPS). We have developed a group of proprieta
ry bisphosphonates containing isoprene… more
Abstract:DESCRIPTION (provided by applicant): According to the American Cancer Society an estimated 21,810 cases of primary malignant brain tumor will be reported in the US in 2008. The ACS also estimates that 13,070 deaths will occur due to these diseases in this
year. This Phase II STTR program advocates… more
Abstract:Today's Warfighter often carries an inordinate load that can lead to injuries and encumbered performance. Equipment is distributed among squad members with little, if any regard for differences in strength and anthropometry. Consequently, the current focus on human-centric design requires a… more
Abstract:This Small Business Innovation Research Phase I project is for the development of technology to crystallize proteins using less sample and with higher speed and success than current high throughput protein crystallization methods. Protein crystallization is an intermediate step in determining the… more
Abstract:The objective of this study is to demonstrate the efficacy and broad applicability of the human immune-modulating alphaGal Adjuvant Technology for antiviral vaccine development. We will use viral vaccine candidates for the select Category A viral pathogens Zaire ebolavirus (ZEBOV, filovirus), Rift… more
Abstract:Determining meat quality attributes in food animals is essential for genetic selection, sorting, and marketing. Ultrasound techniques have the potential to benefit the swine industry for improvements in both quality and yield measures by non-destructive means. There is a need to continually improve… more
Abstract:This Small Business Technology Transfer Phase I project will develop algorithms for a quality control system for colonoscopy (a procedure where the mucosa of the large bowel is inspected via a flexible tube with a camera on it) that has contributed to a marked decline in the number of colorectal… more
Abstract:Etrema Products, Inc. and Applied Research Laboratory at The Pennsylvania State University demonstrated during Phase I that by utilizing the "delta-E" effect in magnetostrictive materials, the resonant frequency of a split ring transducer can be shifted by over 200 Hz for a low frequency transducer.… more
Abstract:The Phase I effort successfully developed an integrated magnetostrictive transducer/amplifier module concept to meet these performance goals: broad bandwidth (7-30 kHz), compact size (approximately 1/2 wavelength at the center frequency), at least 30 Watts output power, and high efficiency. … more
Abstract:DESCRIPTION (provided by applicant): Cystic fibrosis (CF) is caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. The CFTR gene encodes a chloride channel that regulates ion flow across epithelial cell membranes. Most
CF patients have a mutation that deletes… more
Abstract:This Small Business Innovation Research Phase 1 project develops a technology by which diesel fuel consumption can be significantly reduced while increasing productivity in recovering woody biomass. Diesel fuel is the number one operating cost of an industrial grinder and it is estimated that the… more
Abstract:Commercial soybeans require heat processing to deactivate anti-nutrition factors/enzymes. Schillinger Seed has developed a new soybean free of the key anti-nutrition Kunitz Tyrpsin Inhibitor (SKTI-Null). This new SKTI-Null) soybean presents the opportunity for ambient or cold processing of soybeans… more
Abstract:DESCRIPTION (provided by applicant): Our understanding of complex biological phenomena and disease progression has led to the realization that changes in the expression of genes underlie many of these processes. Developing reagents that can selectively al
ter the expression level of any desired… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project is to develop a low cost educational particle image velocimetry (PIV) suite including both hardware and software for fluid science and engineering education at high-school, undergraduate and graduate school levels. PIV technology is… more
Abstract:This Phase I SBIR project develops a novel technology to help plants defend themselves against aphid attack. The currently available insecticidal control methods have the risks of killing beneficial insects and polluting the environment. Plants are capable of using aphid-induced volatile signals for… more
Abstract:DESCRIPTION (provided by applicant): Humans develop natural antibodies against a sugar molecule called Gal, which is present on proteins and lipids in most other species. These antibodies represent one of the strongest natural barriers to infection with ba
cteria, parasites and viruses. NewLink… more
Abstract:This SBIR Phase I project aims to develop a novel surface modification technology for aluminum alloys used in automotive internal combustion engines to improve resistance to friction. The related energy loss due to wear of components directly impacts the fuel efficiency of the automobile. The… more
Abstract:DESCRIPTION (provided by applicant): Parkinson's disease (PD) is a debilitating neurodegenerative disorder characterized by progressive and substantial loss of dopaminergic neurons in the substantia nigra compacta (SNc), resulting in severe neurological si
gns including tremors, bradykinesia, and… more
Abstract:Rotorcraft engineers traditionally use the wind tunnel to evaluate and
finalize designs. Insufficient correlation between wind tunnel results and flight tests,
have been often attributed in part to uncertainty in blockage corrections.
Estimation of rotor blockage is significantly more complex than… more
Abstract:The lack of proper estimation of air loads encountered during transient maneuvers introduces excessive design conservatism. A reduced fidelity CFD methodology based on momentum source (Rot3DC) and a comprehensive analysis code (RCAS) were coupled in Phase I to validate the ''proof-of-concept'' that… more
Abstract:Homologous recombination (HR) permits the precise insertion, deletion, or substitution of genetic material in the genome of an organism. HR offers numerous opportunities for modifying plant genomes to enhance our understanding of plant gene function and regulation, especially with respect to… more
Abstract:We propose to use physiological sensors to measure the quality of a trainee's interaction with a virtual environment (VE) as a function of VE fidelity to enable design improvements in VEs and to enhance training effectiveness through feedback of physiological-based performance information. Currently… more
Abstract:DESCRIPTION (provided by applicant): A collaborative effort between ASL Analytical, Inc. and a research team at the University of Iowa is proposed to development a noninvasive nocturnal hypoglycemic alarm. The goal for the alarm system is to provide con
tinuous noninvasive measurements during the… more
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