Abstract:This Small Business Innovation Research (SBIR) Phase II project is aiming to develop and validate a point-of-care monitoring for tacrolimus, an immunosuppressive medication widely used by organ transplant patients. The product being developed combines the existing, well-developed and low cost… more
Abstract:This Small Business Innovation Research (SBIR) Phase II project will advance the development of electrostatic surface haptics as a means of providing tactile feedback for touchscreens. In electrostatic surface haptics, a user's finger(s) are selectively pulled down to a glass surface by an… more
Abstract:AuraSense Therapeutics is developing oligonucleotide-modified gold nanoparticles called Spherical Nucleic Acid (SNA) constructs, which are a powerful new way of regulating cellular gene expression. AuraSense Therapeutics will use SNAs as genetically programmable antimicrobial agents in a manner to… more
Abstract:DESCRIPTION (provided by applicant): Diagnostic imaging in modern dental practice still relies mainly on visual inspection or x-ray radiography, a technology that remains largely unchanged since the late 1800s. The early detection of small caries and the evaluation of microscopic enamel cracks prior… more
Abstract:DESCRIPTION (provided by applicant): Diagnostic Photonics, Inc. (DxP) is a medical device company developing an intraoperative imaging system for surgical guidance and real-time assessment of cancer tumor margins based on interferometric synthetic aperturemicroscopy (ISAM), a novel modality that… more
Abstract:ABSTRACT: This proposal presents two novel approaches for characterizing manufacturing induced damage in fibrous composites. New developments include integration of discontinuous Galerkin ideas with the variational multiscale finite element methods for the modeling of interface and interphase… more
Abstract:ABSTRACT: We present a mixture theory based approach for process modeling in ceramic matrix composites. The model is derived from a consistent thermodynamic framework for diffusive-reactive flow of an anisotropic, non-linear viscoelastic fluid through a poroelastic body. A salient feature of the… more
Abstract:The innovation is to develop very small audio subsystems for mobile audio devices with unprecedented noise and interference reduction. Audio subsystems are fundamental to many high-volume portable devices such as mobile phones, media tablets, and digital voice recorders. Multiple microphones can… more
Abstract:This Small Business Innovation Research Phase I project will focus on the challenge of reducing the cost of manufacturing Surface-Enhanced Raman Spectroscopy (SERS) substrates. SERS is a powerful analytical technique that is not widely adopted in industry due to the high cost of commercially… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project searches for better materials to efficiently and safely store gases used in semiconductor manufacturing. Currently these gases are stored in tanks at low pressures in dilute concentrations for safety reasons, which requires the use of… more
Abstract:DESCRIPTION: Substance use disorder (SUD) is a major health problem with direct and indirect impact on healthcare and societal cost that is estimated at over 181 billion annually in the United States. Opioids are the second most abused substances and buprenorphine (BUP) is an effective and safe… more
Abstract:DESCRIPTION (provided by applicant): While the high costs of healthcare in the U.S. can be felt by everyone in the country, the economic impact to patients with kidney failure is particularl significant as dialysis treatments can reach 85,000 annually, with transplantation being the only known cure… more
Abstract:This Small Business Innovation Research Program Phase I project proposes a new instrument for imaging live cells and tissues. The instrument addresses the current shortcomings of state-of-the art techniques: expensive and invasive contrast agents that bias the results and shorten the lifetime of the… more
Abstract:This Small Business Innovation Research Phase I project will develop a series of primary and rechargeable Zinc-Air batteries of new generation. Individual cells will use a new and improved interior design, as well as will incorporate in their composition a host of novel materials and innovative… more
Abstract:This Small Business Innovation Research Phase I project will effectively and efficiently recycle post-consumer plastic materials for high value applications through an innovative and environmentally benign approach known as solid-state shear pulverization (SSSP). SSSP subjects the materials to high… more
Abstract:This Small Business Innovation Research Phase I project seeks to revolutionize the manufacture of ultra-high precision, x-ray diffraction gratings. Mechanically ruled, x-ray gratings are used mainly at synchrotron radiation facilities, where they define the wavelength of x-rays used for chemical… more
Abstract:This Small Business Innovation Program (SBIR) Phase I project is to conduct a feasibility study for the development of wireless sensor network application for a personal healthcare product that monitors and gives feedback about sedentary work habits. This society is becoming increasingly aware of… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project will resolve key technical challenges associated with the commercialization of an innovative die-less sheet metal forming process, Double Sided Incremental Forming (DSIF). DSIF locally deforms a peripherally clamped sheet metal component… more
Abstract:This Small Business Innovation Research Phase I project proposes to develop and deliver a high-throughput low-cost nanomanufacturing technology for making high-density high-uniformity omnidirectional-antireflection nanostructures on the entire surface of single crystalline and multicrystalline… more
Abstract:The primary goal of this proposed work is to develop a long wave infrared (LWIR) colloidal quantum dot (CQD)-based focal plane array (FPA) in order to significantly reduce the cost of LWIR hyperspectral imagers. In order to realize this goal, it will first be necessary to successfully fabricate and… more
Abstract:In Phase I, Sivananthan Laboratories (SL) demonstrated the ability to polish Si(211) wafers, as supplied by a vendor with an already fine polish, to an even better surface smoothness and uniformity. SL also demonstrated the molecular beam epitaxy (MBE) growth of CdTe films with better crystalline… more
Abstract:Chemical, biological and explosive (CBE) agents are significant threats to the safety of civilians and military personnel. The objective of this research is to develop a SAMDI label-free sensor for threat detection of trace chemical, biological and explo
Abstract:DESCRIPTION (provided by applicant): Pattern recognition (PR) myoelectric control systems can dramatically improve an amputee patient's control over a powered prostheses, but they have not been made commercially available. Coapt, LLC, is a start-up stagecompany that is seeking to commercialize… more
Abstract:With the promise of low cost and high capacity, silicon-based materials have emerged as the anode of the future for lithium ion batteries. Commercial success has been hindered by limited cycle life, expensive precursors and non-scalable processes. The overall approach will use low- cost microsilicon… more
Abstract:Technical Objective 1: Develop a scalable and plug-and-play unified hybrid multi-scale, multi-resolution, and multi-domain modeling framework for component and system level representation of interactive aircraft power system comprising varied energy generation sources, EAUs, complex loads and load… more
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