Abstract:A number of studies have suggested that noninvasive surgery using high intensity ultrasound ablatiofeasible, and offers significant advantages over conventional surgical techniques for many applicatiultrasound transducer is used to insonate a small tissue target or targets deep within the body… more
Abstract:We will develop an optimized transformation system with Agrobacterium to provide marker-free transgGenetically engineered plants that lack antibiotic or herbicide resistance genes are free of concernenvironmental effects that might arise from the use of these marker genes. Moreover, with each new… more
Abstract:We will test the application of hypermedia for promoting health and safety in the worksite. Specifically, we plan to develop a hypermedia based program for presenting to workers site- specific information on working conditions. The program would be a health promotion and risk management tool as well… more
Abstract:The recently discovered class of remarkably effective anti-HIV-1 natural products known as the calanolides are extremely difficult to obtain from natural sources. We herein propose a total synthesis of calanolide A, the most potent of the compounds reported. What is proposed is more than a natural… more
Abstract:A series of novel fluorinated acyclonucleotides will be synthesized and evaluated for in vitro antiimmunodeficiency virus (HIV) activity. It is expected that selective fluorine substitution in suchsignificant changes in biological activity, thus providing new agents or lead compounds for… more
Abstract:The screening of Chinese medicinal plants for anti-HIV activity has led to the detection of such acSiegesbeckia pubescent. Fractionation of this plant has led to four partially purified fractions witreverse transcriptase. Further fractionation to homogeneity and structure elucidation are proposed… more
Abstract:Our objective is to discover new anti-HIV agents or lead compounds which may be developed into clinthis Phase I program, our research interest will focus on the design and synthesis of novel fluorinanucleotide analogues which would isosterically and isoelectronically mimic the monophosphates of… more
Abstract:Extracts of Blumea aromatic and Blumea riparian were found to exhibit strong inhibitory activity agreverse transcriptase. The extract of Blumea riparian also exhibited antitumor activity. The activethese extracts will be isolated and the chemical structures of the active principles will be… more
Abstract:Nanoscale powders with narrow particle-size distributions significantly reduce sintering time and temperature during the processing of high performance coatings and structural ceramics; their superplastic behavior can be exploited to net-shape form structures. Nanoscale powders can be made by a… more
Abstract:Nanoscale, highly reactive metal oxide powders with very high surface areas are required as destructive adsorbents to treat hazardous substances. Destructive Absorption Technology (DAT) is a non-polluting treatment process that has demonstrated the capability of treating hazardous substances and… more
Abstract:Today\'s submarine towed array handling system operating parameters an methods are equivalent to those used in the late sixties. Attempts to utilize conventional cable handling methods are not suitable for array handling, and appropriate methods have not yet been defined. Outboard system volume,… more
Abstract:LIQUID CRYSTAL MATERIALS HAVE BEEN INVESTIGATED IN THE PAST FOR DETECTING AND VISUALIZING ULTRASOUND IMAGES. HOWEVER, BECAUSE OF THEIR LIMITED DETECTION SENSITIVITY, THE RESULTING "ACOUSTO-OPTICAL" DISPLAYS HAVE NOT BEEN INVESTIGATED FOR MEDICAL IMAGING PURPOSES. RESEARCHERS ARE DEVELOPING NEW… more
Abstract:Galactosyl ceramide (GalCer) acts as an alternative receptor for HIV in CD4 negative cells throughto the HIV envelope glycoprotein gp 120. The design and synthesis of GalCer analogs capable of bindiblocking its interaction with GalCer is potentially a powerful therapeutic approach against HIV… more
Abstract:We will develop a regulated expression system for the extreme thermophile Thermus flavus. This systproduction of commercially important thermostable enzymes. In the Phase I feasibility study we willfrom Thermus, perform minimal structural analyses, and test their regulation using reporter genes… more
Abstract:We propose to develop a what-if analysis tool for hardware/software co-design. It will provide a test-bed in which the user can quickly evaluate hardware/software co-design trade-offs. No tool currently available in the ESDA market supports this essential step in hardware/software co-design. … more
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