Abstract:Our long-term objective is the approval of a new drug application (NDA) for civamide as a topical therpes simplex virus (HSV) infections. In the United States, genital HSV affects more than 25 millioHSV effects up to 100 million individuals. The enormous number of affected individuals makes this… more
Abstract:A novel and ultra-sensitive x-ray fluorescence detector system has been proposed. The detector systconcept of selecting x-ray fluorescence from an elastically scattered background by the diffractionmultilayer. The multilayer will be graded as to satisfy the diffraction condition everywhere on… more
Abstract:ALTHOUGH THIS NATION HAS SOME OF THE GREATEST COAL RESERVES IN THE WORLD, MANY OF THEM WILL REMAIN UNUSABLE UNTIL TECHNOLOGY IS DEVELOPED TO MEET BOTH CLEAN AIR ACT MANDATES AND NEW SOURCE PERFORMANCE STANDARDS (NSPS) FOR PARTICULATE, SULFUR DIOXIDE (SO2), AND NITROUS OXIDE EMISSIONS, EFFECTIVELY… more
Abstract:This project is aimed at building robotic assistants to work with humans in space environments. The key technical innovation is the software integration of a high-level memory architecture capable of deliberative planning and natural language understanding with a reactive execution system capable of… more
Abstract:Oral pharmaceuticals currently are not delivered in gel form because doses cannot be accurately meapouring a gel into a calibrated cup or a spoon. However, an aerosol dispenser recently invented by tfor this project, Dr. James Martin, appears to offer potential as a means for orally administering… more
Abstract:The proposed research effort will provide a new and improved numerical technique for predicting dynamic structural failure. The technique is based on the use of an innovative numerical technique referred to as Element Free Galerkin (EFG) or "gridless" technique developed by Professor Ted Belytschko… more
Abstract:A number of studies have suggested that noninvasive surgery using high intensity ultrasound ablatiofeasible, and offers significant advantages over conventional surgical techniques for many applicatiultrasound transducer is used to insonate a small tissue target or targets deep within the body… more
Abstract:We will develop an optimized transformation system with Agrobacterium to provide marker-free transgGenetically engineered plants that lack antibiotic or herbicide resistance genes are free of concernenvironmental effects that might arise from the use of these marker genes. Moreover, with each new… more
Abstract:We will test the application of hypermedia for promoting health and safety in the worksite. Specifically, we plan to develop a hypermedia based program for presenting to workers site- specific information on working conditions. The program would be a health promotion and risk management tool as well… more
Abstract:The recently discovered class of remarkably effective anti-HIV-1 natural products known as the calanolides are extremely difficult to obtain from natural sources. We herein propose a total synthesis of calanolide A, the most potent of the compounds reported. What is proposed is more than a natural… more
Abstract:A series of novel fluorinated acyclonucleotides will be synthesized and evaluated for in vitro antiimmunodeficiency virus (HIV) activity. It is expected that selective fluorine substitution in suchsignificant changes in biological activity, thus providing new agents or lead compounds for… more
Abstract:The screening of Chinese medicinal plants for anti-HIV activity has led to the detection of such acSiegesbeckia pubescent. Fractionation of this plant has led to four partially purified fractions witreverse transcriptase. Further fractionation to homogeneity and structure elucidation are proposed… more
Abstract:Our objective is to discover new anti-HIV agents or lead compounds which may be developed into clinthis Phase I program, our research interest will focus on the design and synthesis of novel fluorinanucleotide analogues which would isosterically and isoelectronically mimic the monophosphates of… more
Abstract:Extracts of Blumea aromatic and Blumea riparian were found to exhibit strong inhibitory activity agreverse transcriptase. The extract of Blumea riparian also exhibited antitumor activity. The activethese extracts will be isolated and the chemical structures of the active principles will be… more
Abstract:Nanoscale powders with narrow particle-size distributions significantly reduce sintering time and temperature during the processing of high performance coatings and structural ceramics; their superplastic behavior can be exploited to net-shape form structures. Nanoscale powders can be made by a… more
Abstract:Nanoscale, highly reactive metal oxide powders with very high surface areas are required as destructive adsorbents to treat hazardous substances. Destructive Absorption Technology (DAT) is a non-polluting treatment process that has demonstrated the capability of treating hazardous substances and… more
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