Abstract:DESCRIPTION (provided by applicant): Our long-term goal is to develop a novel therapeutic strategy for childhood acute lymphoblastic leukemia (ALL), with focus on relapsed T-cell leukemia. We intend to accomplish this by targeting a unique molecular masterregulator using a new generation of… more
Abstract:ABSTRACT: The Air Force is seeking a compact, high torque, rotary EMA technology capable of controlling flight control surfaces directly at the hinge line in the next generation of thin-wing aircraft. Proposed for this application is an advanced EMA technology based on an axial flux,… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project will develop the use of unique artificial protein sequences, known as entropic bristles, to accelerate the study of protein structure by the method of X-ray crystallography. Many interesting proteins have proven to be difficult to… more
Abstract:The development of Wide Bandgap Semiconductors such as GaN has enabled tremendous improvements in power amplifier performance such as operational frequency and output power. These device improvements have in turn enabled performance and capability improvements in the end applications such as EW… more
Abstract:Failures in aircraft electrical power systems can compromise the readiness, safety, and capabilities of the war-fighter. Furthermore, if the root cause for the failure cannot be quickly identified, this can lead to increased maintenance costs and potential downtime for the aircraft. In this effort,… more
Abstract:State-of-the-art electrical starter/generator (ES/G) systems have become increasingly complex in design and integration due to significant power-demand increase in more electric aircraft initiatives such as the Joint Strike Fighter (JSF). They must provide high performance and high efficiency with… more
Abstract:The overall objective of this research project is to investigate autonomous control architectures for spacecraft power systems. Such techniques will be critical for deep space missions that face inhospitable environments, unpredictable operating conditions, and communication delays. The distributed… more
Abstract:The US Army and Marines rely significantly on fossil-fuel based tactical power generation to provide electrical energy to deployed troops in small camps and forward operation bases. These generators are sized to support the expected maximum power but are often operated far below rated power due to… more
Abstract:ABSTRACT: The move towards more-electric aircraft continues to increase the complexity of electrical power systems (EPS) on modern airborne platforms. In addition to ever expanding peak and regenerative power demands, several of the loads can introduce very high rates of current change (dI/dt)… more
Abstract:The movement to more-electric architectures during the past decade in military and commercial airborne systems continues to increase the complexity of designing and specifying the electrical power system. The addition of numerous high-power electric loads has drastically altered the dynamics of… more
Abstract:PCKA has developed a dynamic, real-time thermal capacity algorithm and gauge for predicting current and anticipated fuel heat sink capability on a fifth-generation tactical aircraft. Relevant internal and external sources and sinks are tracked with prognostics and adaptive intelligence designed to… more
Abstract:The proposed SkySight Technologies Quick Release Connector will independently detect an unexpected mechanical load on the power distribution line.
The compact and lightweight SkySight Quick Release Connector uses existing methods and hardware to integrate into the infrastructure, and no
Abstract:The U.S. portion of the International Space Station (ISS), which has been designated by Congress as a National Laboratory, holds great potential for a broad spectrum of researchers who are eager to take advantage of its unique scientific research facilities. The Light Microscopy Module (LMM), which… more
Abstract:Rechargeable batteries self discharge while in storage, and when allowed to remain at an extremely low state of charge for a long period of time, can be damaged permanently and then must be discarded. The USMC finds it far too costly and impractical to perform manual maintenance recharges every 3 to… more
Abstract:DESCRIPTION (provided by applicant): Techshot, Inc. has successfully completed SBIR Phase I and Phase II research demonstrating that magnetically labeled porcine islets of Langerhans can be isolated from contaminating exocrine tissue by flow sorting usinga quadrupole magnetic separator ( Quadrasep )… more
Abstract:ABSTRACT: Computational electromagnetics and inverse methods are the foundations of modern methods of eddy-current nondestructive evaluation (NDE). In this project, we apply these methods to the problem of characterizing, in three dimensions, damage in complex aircraft structures. As the… more
Abstract:ABSTRACT: To achieve the objectives of condition-based maintenance plus prognosis (CBM+), and realize its potential, the location and size of damage at any length scale, e.g., either a crack or a microstructural perturbation, needs to be determined with statistical metrics to feed prognostic… more
Abstract:Wolf Technical Services, Inc. (Wolf) is developing a Modular Anthropomorphic Test Device (ATD) that is specifically designed for use in blast and ballistic testing. The ATD offers improved biofidelity compared to existing ATDs, with a frangible skeletal system and soft-tissue covering that simulates… more
Abstract:The purpose of this multi-phase program is to develop an autonomous system that is capable of aligning probes for eddy current inspections on steam condensers. The system aligns the eddy current inspection probe over the appropriate condenser tube based on a provided positional information and… more
Abstract:This Small Business Innovation Research (SBIR) Phase II project addresses the unmet needs for effective analysis of protein phosphorylation, a process where a phosphate group is added to a protein to change its function. Protein phosphorylation is a crucial modification of proteins; its… more
Abstract:Fuel cell technology as a clean and efficient energy source has several advantages for military applications, including lower weight, better safety, shorter down time (no recharge time, unlike secondary batteries), and lower heat signature (as compared to combustion engines). Ethanol has the… more
Abstract:There are many different RF devices used in military networks. It is highly desirable to have scalable networks, where new devices can be readily installed without hardware or software changes elsewhere in the network. It is known that achieving this goal
Abstract:DESCRIPTION (provided by applicant): Although some gene mutations can predict response to certain targeted therapies, single-gene testing has limits. Multiple important signaling pathways that may be the causes of human malignancy have continuously been discovered and dissected. Pathway and network… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project seeks to develop novel hyperosmotic nanoemulsions for the prevention and treatment of infected wounds. Wound infections, whether acute or chronic, affects millions of Americans and have significant monetary and physiologic impacts on… more
Abstract:DESCRIPTION (provided by applicant): Inhibitors of Mycobacterial Protein Tyrosine Phosphatase B (mPTPB) for therapy of tuberculosis Aarden Pharmaceuticals Project Summary/Abstract The need exists for a new, breakthrough therapeutic for tuberculosis (TB). Current treatment regimens with toxic… more
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