Abstract:Project Abstract Concordance Health Solutions (CHS) is an Indiana company with a mission to improve patient medication adherence in partnership with pharmacists and other healthcare providers. With this SBIR grant, CHS will develop and test an innovative product, the SMARxT Med Reminder (SMR) Plus… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project aims to develop an efficient remote monitoring and diagnostic software system to detect and diagnose software defects in cyber-physical systems (CPSs). CPSs have the potential to bring about a revolution in efficiency, robustness, and… more
Abstract:This Small Business Innovation Research Phase II project aims to further develop large-scale manufacturing methods for inorganic semiconductor nanowires. These nanowires will be used to make printed photosensors, a superior alternative to conventional light sensing devices. Traditional synthetic… more
Abstract:DESCRIPTION (provided by applicant): Mass spectrometry-based proteomics is an emerging technology that has seen possible applications everywhere. The technique can potentially use one drop of our blood to reveal onset and progress of diseases. Current RandD using plasma/serum proteome sample sets,… more
Abstract:The U.S.s global leadership position in the manufacture of high value chemicals (HVCs) relies on its ability to produce and utilize simple and useful organic (SUO) building block chemicals, a $400 billion a year enterprise based on nonrenewable petroleum feedstock. To maintain U.S.s leadership… more
Abstract:The broader impact/ commercial potential of this project is the development of a catalytic process for the selective production of high value specialty chemicals from lignin. 70 million tons lignin waste, generated by paper and pulp industries and biorefineries annually. While lignin is a rich… more
Abstract:This Small Business Technology Transfer (STTR) Phase I project will demonstrate the superiority of new biomaterial-based excipients (NBBE) to improve drug efficacy and safety and to reduce drug cost. In the pharmaceutical industry, modern drug discovery has brought a large number of drug candidates;… more
Abstract:Abstract Bladder cancer is the fourth most common cancer among men and the seventh most common cancer in women with a life expectancy of only five years after diagnosis. Repair of advanced bladder cancer requires removal of the bladder and construction ofa neo bladder or urinary conduit using… more
Abstract:DESCRIPTION (provided by applicant): The broad and long-term objective of this research project is to use, develop and market an instrument for the simultaneous recording of sympathetic nerve activity (SNA) and electrocardiogram (ECG) using electrodes on the skin. This method (neuECG) was discovered… more
Abstract:DESCRIPTION (provided by applicant): People with traumatic brain injury (TBI) are often plagued with socio-emotional deficits that include difficulty identifying emotions in oneself (alexithymia), difficulty recognizing other peoples' emotions (impaired affect recognition), and empathy loss.… more
Abstract:DESCRIPTION (provided by applicant): The present application Novel Treatment for Posttraumatic Stress Disorder addresses the critical need for efficacious treatments for posttraumatic stress disorder (PTSD). A key neural signaling cascade activated by atrauma experience is initiated by the… more
Abstract:Indiana Integrated Circuits, LLC (IIC) proposes to develop the customizable, high-performance microchip interconnect technology called Quilt Packaging (QP) to address NASA's requirement for high performance integration of heterogeneous microwave systems. QP is an affordable, scalable, patented… more
Abstract:DESCRIPTION (provided by applicant): In recent years there has been increased interest throughout the world in the use of proton radiation therapy for treatment of cancer and independent studies project a 20% annual increase in the installed base. The replacement of X-ray therapy with proton… more
Abstract:The broader impact/commercial potential of this project lies in the ability of the Extended Analog Computer (EAC) to perform filtering operations not possible with current technology. The low power, near instantaneous filtering of complex analog signals, differentiates the EAC technology from DSP… more
Abstract:The broader impacts/commercial potential of this Small Business Innovation Research (SBIR) Phase I project are to enable ultra-high capacity disk drives. The explosion of global digital data and the need to store it is continuing to drive demand for disk storage. Approximately 550 million drives are… more
Abstract:Although rural seniors (people 65 years and over) are living longer, they frequently require ongoing support from caregivers and medical professionals to make that possible. However, rural America has long been represented as having a unique set of obstacles and conditions that make the delivery of… more
Abstract:DESCRIPTION (provided by applicant): The measurement, monitoring and use of bioelectric signals has evolved from the measurement of the electrical activity of the heart to encompass tissues ranging from cardiac, skeletal and smooth muscles, to brain and peripheral nerve tissues. Together with this… more
Abstract:DESCRIPTION (provided by applicant): Most clinical assays begin with blood collection in a laboratory setting. The Gates foundation and many others have recognized and attempted to deal with the fact that in much of the world clinical testing is done in aprimitive setting. The luxury of having a… more
Abstract:The broader impact/commercial potential of this project is significant. The proposed technology could drastically improve the overall effectiveness of pest management programs in various agricultural industries. The proposed system not only eliminates one of the most laborious and dreaded activities… more
Abstract:Domestic US aquaculture is moving toward fishmeal replacement in aquafeeds with a variety of alternative protein sources including plant-based, terrestrial and marine proteins. In our Phase I work we showed the feasibility of modifying the protein quality of several alternate protein sources,… more
Abstract:DESCRIPTION (provided by applicant): Metastasis or dissemination of primary tumor cells is the major cause of mortality in cancer patients. Circulating tumor cells (CTCs) in the bloodstream are key players in the establishment of metastatic tumors. Recentstudies demonstrated that the number of CTCs… more
Abstract:The broader impact/commercial potential of this Small Business Innovation Research (SBIR) Phase I project is to develop a new microscope that integrates biodynamic imaging with conventional phase contrast microscopy for use in drug development and other research applications. Accurately capturing… more
Abstract:Model-based image reconstruction (MBIR) has been demonstrated to have great potential value in a variety of DHS applications including baggage and
cargo CT scanning. However, while MBIR has the potential to reduce artifacts and increase resolution, the computational requirements remain a
barrier to… more
Abstract:DESCRIPTION (provided by applicant): The long-term objective of this STTR project is to commercialize the protein multi-blot Western device, which contributes to improving the productivity and accuracy of conventional Western blot analysis. Although Western blotting has been used for more than three… more
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