Abstract:DESCRIPTION (provided by applicant): Cryo-electron microscopy (cryoEM), in the form of single particle reconstruction (SPR) and cryo-electron tomography (cryoET) analysis are rapidly growing methods for determining the three-dimensional molecular structures of biological samples. This burgeoning… more
Abstract:This proposal investigates methods for graphene synthesis on Si (001) orientated substrates to enable high-volume production of graphene transistors and circuits. The proposed approach to generate a surface with the proper symmetry for graphene epitaxy is to deposit symmetry transformation layers… more
Abstract:ABSTRACT: The primary objective of the proposed effort is to develop a variable-fidelity transient thermal management toolset. Particular emphasis will be given to vapor cycle components with two phase flow analysis capability in the Phase I with expansion to additional components and hardware… more
Abstract:The primary objective of the proposed effort is to develop a real-time thermal capacity algorithm. The algorithm will be capable of quantifying remaining thermal capacity providing an assessment of mission capability. The algorithm will be derived from detailed models of the thermal management… more
Abstract:Electrical starter/generators (ESGs) have become increasingly complex in design and integration due to significant power demand increases in more electric aircraft initiatives such as the Joint Strike Fighter (JSF). These new ESG systems must provide high performance and high efficiency with limited… more
Abstract:The move to more-electric architectures during the past decade in military and commercial airborne systems continues to increase the complexity of designing and specifying the electric power system (EPS). The addition of numerous high-power electric loads has drastically altered the dynamics of… more
Abstract:We propose to design an integrated robotic architecture with natural language dialogue as well as high-level planning capabilities that will allow robots to interact with humans in unprecedented naturalness. The design will be based on our DIARC architecture that has been demonstrated to handle… more
Abstract:The proposed project will develop a direct ethanol fuel cell (DEFC) system based on our recent research breakthroughs in non-platinum catalysts, alkaline ionomers, and anion-exchange-membranes. The AEM-DEFC system will have several advantages, including (1) non-Pt catalysts with ethanol tolerance… more
Abstract:DESCRIPTION (provided by applicant): To establish the proof of concept that Nutrabiotix fiber is safe and well tolerated, promotes gut health by increasing production of short chain fatty acids and changes colonic microbiota composition in favor of bifidob
acteria, improves bowel habit and increase… more
Abstract:DESCRIPTION (provided by applicant): The occurrence of obesity is increasingly growing, and it has been projected that 40% of the US population will be obese by the year 2025. The World Health Organization estimates over 1.6 billion adults (age 15+) are ov
erweight, and at least 400 million are… more
Abstract:Wounded soldiers experience a variety of musculoskeletal defects resulting from ballistic and blast trauma. Improved body armor technology and advanced medical care has decreased mortality due to blasts. However, optimal therapies have not been developed to treat the polytissue trauma that remains.… more
Abstract:Malicious alterations of COTS circuits poses major concern in terms of their reliable and trusted field operation. It is extremely difficult to discover such alterations, also referred to as "hardware Trojans" using conventional structural or functional testing strategies. In this proposal, we… more
Abstract:The Missile Defense Agency (MDA) is developing a new kill vehicle to be employed as part of a missile system upgrade program. One of the performance enhancements under consideration involves improving performance through the integration of data from three sensors, each operating in a different… more
Abstract:DESCRIPTION (provided by applicant): Current LoCs are assay-specific and are custom-built for each single experiment. Performing an experiment requires life scientists to endure the time-consuming process of designing, fabricating, and testing a chip befor
e conducting the actual experiment. This… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project addresses the challenge of achieving variable volume fluid mixing at the microfluidic scale in the context of general-purpose programmable lab-on-a-chip devices (GPLoCs). Directly supporting variable volume mixing is fundamental to… more
Abstract:DESCRIPTION (provided by applicant): This proposal addresses PHS 2009-02 Omnibus Solicitation of the NIH, CDC, FDA and ACF for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44]). Hypertrophic scars commonly form during healing of
deep dermal wounds and are characterized… more
Abstract:DESCRIPTION (provided by applicant): Bladder cancer is the fourth most common cancer among men and the seventh most common cancer in women with a life expectancy of only five years after diagnosis. Repair of the mid stage of this cancer requires excision o
f the diseased area. Surprisingly however,… more
Abstract:The purpose of this work is to characterize the environmental performance of a novel anisotropic conductive adhesive for the assembly of electronic components for military and aerospace markets. Electronic components that are attached to printed circuit board substrates using the anisotropic… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project will develop a system to provide text-to-speech capabilities for a vital and popular scientific device thus providing non-visual operating capacity for such a device, an essential feature for blind/print disabled students. The proposed… more
Abstract:This Small Business Innovation Research (SBIR) Phase I research project entitled Courseload Learning Platform: Digital Delivery and Use of Course Materials in Higher Education proposes to test the technical and commercial merits of an innovation aimed at greatly accelerating the use of digital… more
Abstract:The U.S. faces increasing vulnerability as it depends on expensive, non renewable energy supplies from politically unstable regions. The most common renewable energy sources - wind, solar, geothermal, and traditional hydroelectric - are not growing at an adequate pace to meet demand. The U.S. needs… more
Abstract:DESCRIPTION (provided by applicant): More than 43 million Americans have a disability; of those, 18.6 million have visual disabilities, according to the National Fire Protection Association (Emergency Evacuation Planning Guide For People with Disabilities)
. Fire related incidents contribute to 1… more
Abstract:DESCRIPTION (provided by applicant): In comparison to standard x-ray therapy, proton therapy allows an increased dose of radiation to a tumor and by reducing the amount of radiation to healthy tissue. As a result, it provides the best possible option for u
sing radiation to control and eliminate… more
Abstract:DESCRIPTION (provided by applicant): Dramatic growth of the senior population in the U.S. is widely expected to challenge the capacity of this segment of the U.S. health system. Alternative strategies to support seniors living independently will be critica
l in meeting the short fall. My Health Care… more
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