Abstract:DESCRIPTION (provided by applicant): The osteoporosis market is still in demand for new therapeutics due to the lack of safe orally available bone building drugs. Currently, parathyroid hormone (PTH; FORTEOTM) and its analogs are the only bone building therapies available yet they capture only 8% of… more
Abstract:DESCRIPTION (provided by applicant): Over the last two decades, fMRI has evolved into a widely used technology in basic biobehavioral research. The user base for this technology continues to increase due to the growth of the field of cognitive neuroscience, and this increase is poised to accelerate… more
Abstract:DESCRIPTION (provided by applicant): The ubiquity of high-performance mobile devices, such as smartphones and tablets, has the potential to significantly broaden and improve the methods of data collection used in the biobehavioral sciences. Contemporary mobile devices are capable of highly engaging… more
Abstract:DESCRIPTION (provided by applicant): Individually housing animals, even for a short period, is known to have a negative influence on behavior, learning ability, and physiology. Group-housed rodents are better able to cope with stress through improved behavioral and physiological responses.… more
Abstract:ABSTRACT Tobacco-related deaths cost the United States approximately 200 billion each year. Nicotine is singularly responsible for the dependence-forming properties of tobacco smoking and, once introduced to the body, affects the brain within 15 seconds.Breaking nicotine addiction is challenging… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project aims at developing advanced analog nonlinear algorithms and circuits for mitigation of in-band noise and interference, especially that of manmade origin, affecting various signals of interest and limiting the performance of the affected… more
Abstract:This Small Business Technology Transfer (STTR) Phase I project aims to use a newly discovered peptide (h9e) hydrogel technology to provide an affordable and easy-to-use 3D cell culture system with high throughput screen and accurate in vivo representative. To bridge the fundamental understanding of… more
Abstract:Combat ration Intermediate Moisture (IM) products currently use low pH and water content (aw) to discourage bacterial growth. The long-term goal of this SBIR project is to maintain the microbial stability of IM ration components over a three-year shelf life while increasing the pH and aw values for… more
Abstract:The objective of this project is to design and build a high-efficiency neutron detector array consisting of 3000 pixels, with each pixel being 100 microns wide and 4 cm tall, all based on the microstructured semiconductor neutron detector (MSND) technology. The MSND technology resulted in over 40… more
Abstract:Wetzel Engineering, Inc., proposes research and development to engineer very large wind turbine rotor blades for land-based machines that avoid expensive and logistically challenging transportation requirements. The proposed solution combines two technologies: Sectional component-based assembly of… more
Abstract:ABSTRACT: Energetic Materials Research and Engineering (EMRE), LLC proposes to develop a technique for using residual missile fuel to generate a detonative event that will significantly enhance the blast of the warhead upon impact. This entails the design of an integrated active case and related… more
Abstract:Combat ration Intermediate Moisture (IM) products use low pH and water content (aw) to discourage bacterial growth. The long-term goal of this proposal is to maintain the microbial stability of ration components over a two-year shelf life while increasing the pH and aw values for an improved… more
Abstract:DESCRIPTION (provided by applicant): Current approaches to treat sudden sensorineural hearing loss (SSNHL) do not maintain inner ear drug concentrations within an appropriate therapeutic window for sufficient lengths of time to achieve therapeutic effect.A novel delivery system for long-term,… more
Abstract:DESCRIPTION (provided by applicant): Pediatric drug development presents many unique challenges in the effective treatment of diseases in children, from adequate dosing information and pediatric-specific testing to palatable flavor profiles and effective delivery formats. A novel technology that… more
Abstract:During the Phase I SBIR project funded by DLA, Fairmount Technologies (FT) has developed and proven a new CNC metal forming process called stretch roll forming (SRF) that can produce complex parts made out of extrusions without part-specific dies. The proofof- concept machine developed has stretch… more
Abstract:DESCRIPTION (provided by applicant): The proposed effort is aimed at the development and evaluation of a wireless electronic location system for reporting the location of individuals with autism and other cognitive disabilities, who may wander or elope. This is a very vexing and routine problem for… more
Abstract:DESCRIPTION (provided by applicant): The proposed effort is aimed at the evaluation of a wireless electronic location system for reporting the location of individuals with Alzheimer's Disease and other Dementia (ADOD), who tend to wander or elope. This isa very vexing and routine problem for… more
Abstract:This proposal details the development of a variable pulsed power circuit and custom load that simulates the audio, visual, and tactile response of a variety of explosive devices. The system operates by tailoring the voltage and current discharge profile through the stimulus generator at the… more
Abstract:The AirCore is a simple and novel atmospheric air column sampler to validate satellite observation data of greenhouse gases, using a lightweight, inexpensive coated stainless steel coil. The simple design of the leads to cost savings during manufacture and operation. The addition of a UAV to the… more
Abstract:Under U.S. defense policy, the Navy is responsible for delivering satellite communications to"disadvantaged"users, the term for intelligence officials and troops working in remote areas, often with no more resources than backpacks or small vehicles. MUOS is slated to provide coverage for… more
Abstract:The proposed research incorporates several inventions to produce structural components that are assembled into a highly enhanced Toxic Material Forensic Container (TMFC) for transport and storage of contaminated articles. Bio-hazardous materials are frequently encountered in investigations, and the… more
Abstract:With the notable exception of glucose, most metabolic biomarkers cannot be accurately, and practically measured over long periods, in vivo and in real-time. A primary reason is stable, selective enzymes suitable for biosensors are not available. Biosensors could revolutionize acute and long-term… more
Abstract:DESCRIPTION (provided by applicant): Degeneration of sleep quality with age is a well-documented phenomenon. While much is known regarding the characterization of this decline, remarkably little of the physiology or genetic underpinnings are understood. Age-related sleep changes in rodents (mice +… more
Abstract:DESCRIPTION (provided by applicant): Tobacco-related deaths cost the United States approximately 200 billion each year. Nicotine is singularly responsible for the dependence-forming properties of tobacco smoking and, once introduced to the body, rapidly affects the brain within 15 seconds. Breaking… more
Abstract:DESCRIPTION (provided by applicant): The aim of this application is to develop, prototype, validate, manufacture and commercialize a new, generalized microbiosensor designed for non-human use and based on functionalized nanoparticles. The microbiosensors produced will enable in vivo monitoring of a… more
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