Abstract:We propose the development of a simple, low cost technology for the field placement of ultra-high performance concrete (UHPC) that consists of a modified Gunite system and an improved UHPC formulation. The Gunite system includes modifications that overcome a number of problems related to the… more
Abstract:DESCRIPTION (provided by applicant): The baculovirus expression vector system (BEVS) is a proven, powerful and versatile method of eukaryotic protein expression. It is used to produce vaccines, diagnostics, and biologically active proteins for a multitudeof research projects. Like all expression… more
Abstract:DESCRIPTION (provided by applicant): We have developed a protocol that reproducibly induces transplantation tolerance in individuals undergoing a living related donor kidney transplant. Three subjects have been off all immunosuppression for 10 months, 2 months, and 1 month respectively and have… more
Abstract:DESCRIPTION (provided by applicant): The major barriers to preventing or treating Alzheimer's disease (AD) are its unknown pathogenesis/etiology and the lack of an objective, sensitive and specific biomarker of the disease, particularly at the early stageswhen therapeutic interventions would… more
Abstract:DESCRIPTION (provided by applicant): Heart failure (HF) remains one of the largest unsolved problems in health care today and continues to increase in incidence and cost ( 34.8 billion in US in 2008). Prognosis remains limited especially in patients with advanced heart failure. Transplantation is… more
Abstract:DESCRIPTION (provided by applicant): There are an estimated 26 million Americans with early chronic kidney disease (CKD). Early diagnosis and treatment are the only cost-effective means to reverse this growing problem. NIH recognizes the challenge to diagnose CKD early during its initiation and… more
Abstract:ABSTRACT: nGimat proposes to develop a novel technique to sinter ceramic films deposited onto metallic substrates by combining two efficient and inexpensive techniques: flame sintering and field-assisted"flash"sintering. The creativeness of this approach lies in the concept to use a… more
Abstract:DESCRIPTION (provided by applicant): Left ventricular assist devices (LVADs) are increasingly applied to treat advanced heart failure, demonstrating improvement of morbidity/mortality and quality of life. Right heart failure (RHF) affects up to 40% of LVADpatients and significantly contributes to… more
Abstract:In the context of post-combustion CO2 capture processes, solvents with fast CO2 absorption rates will require more energy for regeneration. This challenge is exacerbated when aqueous solvents are applied to the capture of post-combustion CO2 from a utility gas stream, which contains such unique… more
Abstract:DESCRIPTION (provided by applicant): In the absence of effective, approved vaccines or therapeutic measures against dengue and other mosquito borne pathogens, public health efforts must focus on the control of mosquito vectors that are required for transmission. Unfortunately, effective control… more
Abstract:Okeanos Technologies is developing a desalination system that used Ion Concentration Polarization (ICP) elements and modular arrays. ICP can separate water from solutes and contaminants far more efficiently than Reverse Osmosis (RO) or Electrodialysis(ED) because no extreme hydraulic pressures or… more
Abstract:DESCRIPTION (provided by applicant): Traditional approaches to drug development for Alzheimer's disease are becoming increasingly expensive and in many cases disappointingly unsuccessful. Based on preliminary in vitro and in vivo studies we have identifieda novel lactam derivative of the… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project aims to eliminate the use of heat during the process of spray drying liquid emulsions into powders. Typically, a liquid emulsion consists of a high-value liquid ingredient emulsified with a carrier system that when dried captures the… more
Abstract:This Small Business Innovation Research Phase I project entitled ?Smart Filter for Fast Chemical Reaction Clean-up? tackles an important problem in the manufacturing industry, namely, the labor-intensive nature of chemical synthesis and its hazardous conditions, which, unfortunately, have not… more
Abstract:CEPEDA's Shipboard Cardboard Preprocessing System utilizes modular sensing and stripping sections that ensure all tape and plastic labels are removed from the input cardboard. An innovative sensor has been conceived and tested on the bench top that can accurately distinguish tape and labels on… more
Abstract:DESCRIPTION (provided by applicant): Cervical cancer, which is caused by HPV infection, is characterized by the progressive formation of dysplastic lesions, known as cervical intraepithelial neoplasia (CIN). Although vaccinations for the prevention of cervical cancer have been developed, the… more
Abstract:DESCRIPTION (provided by applicant): Amongst the different cancer types afflicting the US population, glioblastoma multiforme (GBM) is a dreadful disease with an overall average survival of 10 months. With about 8,000 new cases per year, representing onlyabout 2% of new cancer patients, this disease… more
Abstract:DESCRIPTION (provided by applicant): Brockman-Hastings LLC seeks to reduce vision loss for glaucoma sufferers by creating a simple, accurate, and clinically acceptable sensor for monitoring intraocular pressure (IOP). Trends indicate that by 2020, approximately 80 million people worldwide will… more
Abstract:DESCRIPTION (provided by applicant): The specific aims of this proposal are to use a newly developed intracellular energy delivery technique to enhance resuscitation, and to study the relationship between tissue high-energy phosphate supplementation and tissue necrosis and apoptosis during… more
Abstract:Recent study by Candes et al. proves that that matrix completion is able to recover the missing entries from a surprising small fraction of random known entries if the matrix admits certain properties. The theoretical advance of the matrix recovery fosters a number of applications such as… more
Abstract:DESCRIPTION (provided by applicant): The present lack of blood-based diagnosis requires AD patients to be subjected to either invasive spinal fluid (CSF) tapping, expensive MRI or PET imaging, or arduous psychological testing, all unsuitable and costly forour elderly. Strategically, we shall address… more
Abstract:Research is proposed for the development of a state-of-the-art computational aeroelastic tool. This tool will include various levels of fidelity and the ability to perform computational uncertainty quantification for data-driven risk analysis and certification. A number of novel reduced-order in… more
Abstract:The proposed work will establish high fidelity computational methods and wind tunnel test model in support of new freeplay criteria for the design, construction and controlled actuation of control surfaces with varying amounts of freeplay and their aeroelastic response. These methods will be… more
Abstract:The need to accurately predict aeroelastic phenomenon for a wide range of Mach numbers is a critical step in the design process of any aerospace vehicle. Complex aerodynamic phenomenon such as vortex shedding, shock-turbulence interaction, separation, etc. dominate at transonic and supersonic Mach… more
Abstract:DESCRIPTION (provided by applicant): With over 8.5% of the U.S. population and 75 million people worldwide meeting the diagnostic criteria for alcohol use disorders (AUDs), alcohol abuse is among the top three preventable public health problems in the U.S.and the world. AUDs, commonly referred to as… more
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