Abstract:This proposal is in response to rapid modeling need in our military force. We plan to develop and demonstrate a framework that will allow warfighters to rapidly acquire and edit geospecific terrain databases, including both building exterior and interiors. The output of our models will be in… more
Abstract:DESCRIPTION (provided by applicant): According to the National Survey of Drug Use and Health (NSDUH) of 2008, 7.2 million Americans are in need of treatment for Substance-Related Disorders (SRDs), and a large proportion of those need treatment for opiate pain reliever, heroin, and alcohol addiction.… more
Abstract:This SBIR Phase I project will reduce health costs and increase accessibility to diagnostics by reducing the cost of manufacture, and increasing manufacturing volume of superior quality microfluidic devices. The proposal seeks to develop a platform technology that produces the same manufacturing… more
Abstract:DESCRIPTION (provided by applicant): Neurodegenerative and malignant diseases of the central nervous system affect millions of Americans. These diseases are often devastating and difficult to treat, and effective drug delivery remains a significant challenge. Infusion of drugs nto the brain… more
Abstract:DESCRIPTION (provided by applicant): Obesity is recognized as a national and global epidemic, as approximately 65% of adults in the United States are classified as overweight or obese as defined by body mass index (BMI). In fact, in the year 2000, the human race reached a historical landmark, when… more
Abstract:ScienceTomorrow in collaboration with Dr. David C Joy, at the University of Tennessee Research is proposed to fabricate direct digital Quantitative Secondary Electron Detectors (QSED) for scanning electron microscopes (SEMs). If successful, commercial versions of the QSED would transform the… more
Abstract:DESCRIPTION (provided by applicant): The dental profession has searched for many years for additional real time chair-side measures to provide objective measures to aid in the monitoring of periodontal health and early diagnosis of disease. Research efforts have produced solid evidence that… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project, if successful, will demonstrate the application of filtered light to increase the productivity of large scale microalgal cultivation. Traditionally, algae growth has depended on natural solar radiation to be economically viable. However… more
Abstract:In the tactical wireless ad hoc network, all networking nodes are vulnerable to various security attacks. Therefore, the centralized data storage is unable to protect the tactical data once the storage device is compromised by an adversary. Distributed data storage is the alternative that the data… more
Abstract:ABSTRACT Technological aids supporting medication management for chronically ill patients are proliferating, offered in electronic telehealth devices. Pill organizers, reminders, monitors, and usage communicators have enabled an array of home health aids to support users and caregivers in pill… more
Abstract:Opiate-agonist pharmacotherapy utilizing buprenorphine/naloxone is known to decrease illicit opiate use. However, poor medication management and misuse during self-managed opioid substitution therapy (OST) constrains efficacy, while aggrandizing relapse,hospitalizations and mortality. One of the… more
Abstract:DESCRIPTION (provided by applicant): This project aims to generate blood tests for: 1. mild cognitive impairment (MCI), and 2. conversion risk from MCI to full-blown Alzheimer's disease (AD). We have reported that systemic footprints, increases in key micro- RNA (miR) levels, are identifiable… more
Abstract:The modeling and simulation of human performance is often difficult because there is no uniform framework for expressing the content and structure of a human performance model and all but impossible to compare and contrast across different models despite the abundance of quantitative modeling tools.… more
Abstract:ABSTRACT: In order to make flight combat training more efficient and effective, many strides have been made in the areas of role-based competency definition through the use of Mission-Essential Competencies (MECs), live-virtual-constructive (LVC) simulation for realistic practice and assessment in… more
Abstract:ABSTRACT: The high operations tempo, frequent deployments and other fact-of-life events limit the availability for team training. To mitigate this training availability problem, training simulations need to incorporate constructive entities as teammates in a way that enhances training for the human… more
Abstract:TiER1 Performance Solutions proposes to develop CATS (Competency-based Adaptive Training System)a system to address common warfighter training needs in the Air and Space Operations Center. The goal of this effort is to prepare warfighters for mission readiness by integrating: a Learning Management… more
Abstract:DESCRIPTION (provided by applicant): Our goal is to develop a new molecular entity with a novel mechanism of action for targeting and eliminating glioblastoma multiforme (GBM, high grade glioma), a deadly and invasive brain tumor with no effective treatment. Of the 12,000 patients expected to be… more
Abstract:DESCRIPTION (provided by applicant): This project aims to demonstrate that the evolution of plant biosynthetic pathways can be accelerated and driven to favor the synthesis of ligands which interact with a specific human target protein. This is achieved bysubjecting mutant plant cells to selection… more
Abstract:DESCRIPTION (provided by applicant): The baculovirus expression vector system (BEVS) has been successfully utilized to produce thousands of proteins for use as vaccines, therapeutics, and for structure-function studies. One limitation of BEVS is the propensity of baculoviruses to accumulate… more
Abstract:DESCRIPTION (provided by applicant): Chronic wounds and ulcers are increasing with the growing incidence of diabetes and associated illnesses and have annual costs exceeding 20 billion. These non-healing wounds result in chronic disease, limb amputationsand death and are complicated by antibiotic… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project proposes to demonstrate the feasibility of a new type of advanced hydrodesulfurization (HDS) catalyst for deep desulfurization purposes. Specifically, metal nanoparticles supported on zinc oxide nanowires are proposed for creating higher… more
Abstract:Longhurst Engineering, PLC, and Vanderbilt University propose an in-space friction stir welding (FSW) machine for joining complex structural aluminum components. The proposed FSW machine is innovative because it can be deployed by 2 people and be used to weld complex surfaces that extend beyond… more
Abstract:DESCRIPTION: The following proposal is a follow-on Phase 2 b application from our initial proposal (1-R42 DA 030001). U.S. drug overdose deaths, mostly commonly from opioids, now exceed deaths from automobile accidents. There is a significant unmet medical need to provide additional pharmacologic… more
Abstract:Lack of fresh water hinders economic development, devastates human health, leads to environmental degradation and foments political instability. We obtain our water from limited and unevenly distributed surface and underground fresh water sources. Over withdrawal from these quasi-renewable… more
Abstract:This Small Business Innovation Research Phase II Project of ?No Heat Spray Drying? fundamentally changes the process of spray drying liquids to powders by eliminating the use of heat. Typically, a liquid emulsion consists of a high value liquid ingredient that is emulsified with a carrier system… more
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