Abstract:DESCRIPTION: The following proposal is a follow-on Phase 2 b application from our initial proposal (1-R42 DA 030001). U.S. drug overdose deaths, mostly commonly from opioids, now exceed deaths from automobile accidents. There is a significant unmet medical need to provide additional pharmacologic… more
Abstract:This proposed Small Business Innovation Research Phase II project will develop a novel nano- scale process for synthesizing sulfur-infused carbon composite cathode materials to produce high- energy density lithium-sulfur (Li-S) secondary batteries with a high rate of charge/discharge and… more
Abstract:This Small Business Innovation Research Phase I project will develop a novel secondary battery platform based on a lithium sulfide-carbon composite cathode and a silicon anode that demonstrates high energy density and long cycle life. Today, mobile devices require faster performance and smaller… more
Abstract:Lack of fresh water hinders economic development, devastates human health, leads to environmental degradation and foments political instability. We obtain our water from limited and unevenly distributed surface and underground fresh water sources. Over withdrawal from these quasi-renewable… more
Abstract:This Small Business Innovation Research Phase II Project of ?No Heat Spray Drying? fundamentally changes the process of spray drying liquids to powders by eliminating the use of heat. Typically, a liquid emulsion consists of a high value liquid ingredient that is emulsified with a carrier system… more
Abstract:The innovation will enable real-time decision support for large-scale water infrastructure systems, through the fusion of operational data and infrastructure-aware predictive models. These real-time software instruments will leverage significant investments by drinking water utilities in Supervisory… more
Abstract:DESCRIPTION (provided by applicant): The specific aim of this phase I proposal is to test our newly developed intracellular ATP delivery technique for abdominal wound dehiscence. More than 200,000 incisional hernia repairs are performed annually in the United States at a financial cost of nearly 2.5… more
Abstract:The innovation aims to develop a patent-valuation system that considers the totality of a United States patent's ?prior-art? patent-citations. Using network mathematics of eigenvector centrality, a patent's intrinsic value is calculated based on recursively weighting associations between a… more
Abstract:This Small Business Technology Transfer (STTR) Phase I project proposes to demonstrate the feasibility of software for the development of solutions to complex life science problems. Life science is truly an interdisciplinary field for which real collaborations can substantially advance the level of… more
Abstract:The current installation rate of wind turbine generators is on track to meet DOE published goals of 20% wind source of electricity by 2030. As the most economical sites become populated, future installations will rely more heavily on low wind speed on-shore site locations and high wind speed… more
Abstract:The United States Department of Energy, along with researchers in industry, and academia has identified an urgent need for Bismuth Strontium Calcium Copper Oxide superconducting precursor powder. This material is a high-temperature superconductor that will be used in powerful magnets for… more
Abstract:Electric vehicles, including hybrids in the nearer term, are the principal transportation technology by which the United States can become independent of foreign oil, can become energy independent overall, and can effect control over greenhouse emissions. For this to become reality, electric vehicle… more
Abstract:DESCRIPTION (provided by applicant): Human Microvessel Culture System (hMCS) Angiogenesis-targeting therapies, either inhibiting or promoting new vessel growth, have the potential for treating numerous diseases including cancer, eye diseases, cardiac and peripheral vascular disease, skin disorders,… more
Abstract:DESCRIPTION (provided by applicant): Every year in the United States, approximately 132,000 patients undergoing anti-cancer therapy develop oral mucositis (OM), a painful, debilitating oral wound condition, which is estimated to increase the patient's cost of care by 17,000-43,000. Most… more
Abstract:DESCRIPTION (provided by applicant): Snoring is a condition that affects people of all ages, with a reported prevalence of up to 48% of men and 34% of women. Snoring poses not only an inconvenience with regard to sleep-cycle disruption of the sufferer's bed partner and family, but it can also… more
Abstract:DESCRIPTION (provided by applicant): Colorectal cancer is the third most common form of cancer and the second leading cause of cancer-related death in the US. Yet, if polyps are detected and removed early, colorectal cancer is largely preventable. Althoughoptical colonoscopy (OC), the current gold… more
Abstract:DESCRIPTION (provided by applicant): The basic functions of sleep are still unknown. Abnormal sleep patterns can manifest as a variety of disorders-sleep apnea, parasomnias, REM (rapid eye movement sleep) behavioral disorder (RBD), narcolepsy-many of whichare influenced by heredity. There is an… more
Abstract:DESCRIPTION (provided by applicant): It is well established that aging and many chronic diseases, such as cancer and heart failure, are associated with significant losses in skeletal muscle mass and strength in humans. There is agreement across the musclebiology community that important… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project proposes to develop an ultra-low-power electrostatic switch relay for the purpose of managing ultra-low-power energy harvesting. Normal power management for energy harvesting, which involves controlling the release and storage of the… more
Abstract:ABSTRACT: In the future, numerous military database, documentation, and mission-critical information systems will be migrated to the clouds, due to cloud cost-efficiency and accessing flexibility. However, the cloud servers are generally untrusted either for data owners or users. In this proposal,… more
Abstract:Simply encrypted data storage is unable to prevent data loss or compromise if the storage device is damaged or compromised by an adversary. Distributed data storage is the alternative that divides the original data into fragments and secretly stored them on distributed devices with certain… more
Abstract:We investigate a problem of significant practical importance, namely, the recovery of the data matrix from a partial set of its entries that are collected in a noisy environment (i.e., a noisy partial matrix). Our proposed Near-Optimal Matrix Completion (NOMC) target to provide a leading approach… more
Abstract:ABSTRACT: ADI and ASU propose to develop a novel methodology for blade peak stress prediction from limited strain gage/tip-timing measurements when multiple vibratory modes are present. The current protocol assumes that only one mode is present and only provides upper and lower bound estimates of… more
Abstract:DESCRIPTION (provided by applicant): According to the National Survey of Drug Use and Health (NSDUH) of 2008, 7.2 million Americans are in need of treatment for Substance-Related Disorders (SRDs), and a large proportion of those need treatment for opiate pain reliever, heroin, and alcohol addiction.… more
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