Abstract:Orbital pipe welding systems can function like skilled welders, to certain extent, who can move the torch very smoothly/evenly. However, their adjustment of welding parameters is not a true emulation of skilled welders who observe the weld pool and adjust welding parameters based on the observation… more
Abstract:DESCRIPTION (provided by applicant): Assenti LLC is a 10-person start-up company formed out of collaborative research teams from the University of Louisville's Speed School of Engineering and the Department of Ophthalmology & Visual Sciences along with key industry partners. Assenti's enclosed SBIR… more
Abstract:DESCRIPTION (provided by applicant): Oral candidiasis (oropharyngeal candidosis or thrush) is a common infection in immunosuppressed individuals, and, if not blunted, can transit to esophageal candidosis or life-threatening candidemia. These potentially life-threatening fungal infections originate… more
Abstract:DESCRIPTION (provided by applicant): Irritant and allergic contact dermatitis affect approximately 10% of adults, and hand eczema represents one of the four most common occupationally related diseases, accounting for substantial lost earning potential in otherwise healthy populations. Both irritant… more
Abstract:DESCRIPTION (provided by applicant): The goal of this project is to develop a safe biocidal vaginal gel for treatment of vulvovaginal candidiasis (WC). WC is caused by one of several airborne species of the yeast Candida that are normal inhabitants of humans at several sites, including the vagina. C… more
Abstract:DESCRIPTION (provided by applicant): This project proposes to develop an electrical stimulation augmented exercise device for individuals with incomplete spinal cord injury (iSCI). The device will provide a closed-chain, load bearing lower extremity exercise that has the potential to increase muscle… more
Abstract:DESCRIPTION (provided by applicant): Thousands of people every year experience long-term or lifelong disabilities in motor, sensory, and cognitive function as result of central nervous system (CNS) injuries. There has been little hope for recovery from these dysfunctions because axons from injured… more
Abstract:This SBIR Phase I project will bring together research in biometrics and information systems by developing new techniques that learn and then continuously monitor a user's biometric features locally, freeing the information system from the task of managing identities or participating in the… more
Abstract:DESCRIPTION (provided by applicant): The overall goal of this project is to develop a retina implantation instrument kit that will allow: 1) retinal surgeons to harvest, dissect, and transplant sheets of undifferentiated fetal retinal tissue with its retinal pigment epithelium (RPE) and then… more
Abstract:Insects are major pests of plant and animal food and fiber and also vector diseases causing millions of human deaths and untold suffering annually. Moreover, our efforts to control insect pests have caused massive environmental contamination and continue to cause human and animal fatalities annually… more
Abstract:DESCRIPTION (provided by applicant): The incidence of congestive heart failure (CHF) is increasing worldwide with over one million new cases diagnosed annually. Over the past 30 years, counterpulsation with an intra-aortic balloon pump (IABP) has been widely and successfully used as a short-term… more
Abstract:DESCRIPTION (provided by applicant): The long term objective of this project is to develop validated, genotype-based biomarkers to aid in more accurate diagnosis of schizophrenia and related schizophrenia spectrum disorders, including bipolar disorder. SureGene, LLC is developing two novel genetic… more
Abstract:The target of the proposed work is to provide additional properties to aircraft composite surfaces including color play that is heat sensitive and/or impact sensitive and which provides the coatings with a special mechanism that recognizes external force (heat/impact) to the coating and also… more
Abstract:Farmers in Kentucky are looking for ways to diversify their production and marketing. High value crops, such as specialty peppers may provide one avenue for diversification. However, storability of certain specialty peppers has not been determined, and if the peppers can not be stored, the… more
Abstract:DESCRIPTION (provided by applicant): Cancer is one of the major causes of death in the U.S. and many developed countries with an estimated economic burden of over 100 billion dollars in direct and indirect costs in the U.S. alone. Although surgery, chemotherapy, and radiotherapy are commonly used… more
Abstract:DESCRIPTION (provided by applicant): The goal of this project is to develop a novel topical drug delivery vehicle to treat postherpetic neuralgia [PHN). PHN is defined as pain in the affected dermatome that persists or appears after the rash of herpes zoster (HZ) has healed. Although many cases of… more
Abstract:DESCRIPTION (provided by applicant):
The goal of this project is to develop a unique, safe and efficacious mouth rinse to treat oral candidiasis in patients with cancer. Oral candidiasis or oral thrush is a disease caused by all species of the fungus Candida and is a common infection for… more
Abstract:DESCRIPTION (provided by applicant): Disorders of keratinization are a heterogeneous group of diseases characterized by dry and scaly skin that demonstrate changes in the biophysical properties of the stratum corneum, especially with respect to the water permeability barrier. These diseases, also… more
Abstract:DESCRIPTION (provided by applicant): This project proposes to develop a device that will improve the quality and availability of motor retraining for individuals with neuromotor disorders due to stroke or incomplete spinal cord injury. Biofeedback of postural control variables such as ground… more
Abstract:DESCRIPTION (provided by applicant):
The purpose of this proposal is to provide proof-of-concept that a novel therapy that prevents complement activation could be effective in reducing ischemia reperfusion injury (IRI) in transplanted organs. Complement activation after IRI in transplanted organs… more
Abstract:This proposal describes the continued development of passive, orthogonal frequency coded (OFC) surface acoustic wave (SAW) sensors and multi-sensor systems, an enabling technology for remote wireless sensing of temperature, pressure, and a range of other measurands, for application to space… more
Abstract:This Small-Business Innovation Research (SBIR) Phase I project will explore the feasibility of developing a multi-media data structure to model and store geometric measurement and motion characteristics of a living, moving creature. The objective is to develop tools for storing and accessing data… more
Abstract:DESCRIPTION (provided by applicant): Autologous skin grafts are the preferred method for covering large burn surfaces. The healing of autologous skin grafts, and the re-harvesting of skin donor sites for autologous skin grafts, is often slowed by the altered metabolic state of burn victims.… more
Abstract:DESCRIPTION: This proposal is submitted in response to the program announcement PA-03-123 "Development of diagnostic screening test for salt sensitivity (SBIR/STTR)" from the National Institute of Diabetes and Digestive and Kidney Diseases. The overall hypothesis of our laboratory is the principle… more
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