Abstract:DESCRIPTION: The distinctive arginine requirement of hepatocellular carcinomas
and malignant melanomas provides the basis for a new potential chemotherapy.
Just as acute lymphocytic leukemia cells require asparagine and E. coli
asparaginase enzyme can be used to effect a… more
Abstract:DESCRIPTION (PROVIDED BY APPLICANT): The long-term goal of the proposed
research is the development of effective anti-cancer agents, modified human
tumor necrosis factor-alphas (hTNFas). TNFa is a potent anti-neoplastic agent
but its therapeutic application has been… more
Abstract:An extremely simple Permanent Magnetic Linear Shaft Coupler is presented that would magnetically couple the linear motion of a hermetically sealed shaft with an Actuator that operates in ambient conditions. The proposed Coupler will eliminate potential leak paths for the cryogenic valves at the… more
Abstract:DESCRIPTION (provided by applicant): Based on the extensive data generated
during the phase I portion of our studies, there is sufficient and compelling
information to support the further development of the highly lipophilic and
blood-stable topoisomerase inhibitor, DB-67.… more
Abstract:DESCRIPTION (PROVIDED BY APPLICANT): DB-67 is a promising new silatecan
(silylcamptothecin) analog that displays superior blood stability relative to
the FDA-approved camptothecin congeners, topotecan and CPT- 11. DB-67 also
exhibits a high degree of anti-cancer potency… more
Abstract:Not Available This initiative designs and fabricates robust, solid state, ultra-high spectral resolution filters, for use at 1064 nm and 355 nm as a lidar receiver with doppler capability. The two systems are similar, except for pre-filtering and dispersive element co
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