Abstract:We recently discovered that antibodies can be photolabeled with photoreactive adenosine probes with high efficiency while maintaining full antigen binding capacity. The photoreaction takes place at micromolar concentration under physiological conditions and in short time. Labeled tryptic peptides… more
Abstract:Strategic University Resources porposes to develop a method for detecting internal damage in thick-walled composite structures. The proposed real-time, nondestructive method will be convenient and fast enough to use for 100% inspection of parts prior to their placement in service. The proposed… more
Abstract:The ultra-high strength steels, AF 1410 and AerMet 100, have improved fracture toughness and stress corrosion cracking resistance, desirable mechanical properties for naval aircraft landing gears. However, the absence of accurate machining information on the various operations necessary to… more
Abstract:The collection of sufficient quantities of truly representative ambient samples (e.g., air, water) for analysis is a serious problem with any mobile air sampling and monitoring system. There are several ways this problem can be addressed. The approach proposed in tihs SBIR is twofold. First, a… more
Abstract:Many of the solid-state chemical microsensors, including surface acoustic wave (SAW) devices and the organic or inorganic semiconductors, are ideally suited as sensors for on-chip chemical analysis systems as they are inherently very small, low power and readily manufactured by photolithographic… more
Abstract:This project will design, develop, and field test an interactive multimedia program to enhanceawareness of uses of technology by children with disabilities. The information will be presented in astory.book format using CD-ROM technology. The target audience will be students with disabilities,… more
Abstract:THIS PROJECT DEVELOPS AND FIELDTESTS A COMMERCIAL PROTOTYPE SOFTWARE PACKAGE DESIGNED TO PROVIDE USERS OF SINGLE-SWITCH INPUT DEVICES CONTROL ACCESS TO EDUCATIONAL SOFTWARE, MULTIMEDIA PROGRAMS, AND RECREATIONAL ACTIVITIES FOR IBM AND PC-COMPATIBLE COMPUTERS. THIS POPULATION INCLUDES INDIVIDUALS… more
Abstract:The investigator is developing Enzocide for use in the egg processing industry. The incidence of fooutbreaks associated with Salmonella has risen steadily since the mid 1970s. The monetary cost of saestimated at 4 billion dollars, annually. The primary cause of salmonellosis has been linked to… more
Abstract:The observed antigenic cross-reactivity between the Borrelia species that causes Lyme disease and Bthat causes Relapsing Fever is one of the problems in confirming cases of Lyme disease in areas endeinfections. As thedemand for the development of Lyme disease diagnostic procedures increases, it isbe… more
Abstract:Light induced chemical reactions (so-called photochemical activation) can be done under mild conditare physiological for biologically active macromolecules. We have recently used such photo-chemistryorganic molecules to antibodies. The photolinker contain side chains which can act as chelaters… more
Abstract:STUDIES BY THE APPLICANT ON THE METABOLISM AND PHARMACOLOGY OF ADD17014, A NOVEL TRIAZOLINE ANTICONVULSANT, HAVE LED TO THE DISCOVERY OF THE AMINOAKYLHETEROCYCLES AS A UNIQUE CLASS OF ANTICONVULSANT AGENTS. INITIAL WORK ON AMINOALKYLPYRIDINES INDICATE THEY ARE NONTOXIC, AND HIGHLY EFFECTIVE BY THE… more
Abstract:Solid-state microsensors are very small, rugged, low cost, devices that can be highly sensitive to their chemical environment. Due to their unique capabilities, they have considerable potential as in- place sensors for engine condition monitoring, especially as real-time monitors of lubricants,… more
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