Abstract:DESCRIPTION (provided by applicant): The use of research animals in research has been essential to development of vaccines and study of most human diseases. Modern rodent research is increasingly powerful with the ability to manipulate the genomes of miceand rats such that they closely mimic complex… more
Abstract:DESCRIPTION: Renal transplantation is the preferred therapeutic approach for end organ failure. However, the chronic use of immunosuppressive agents is critical to prevent rejection. The drugs are costly ( 15,000-25,000/year) and have significant toxicities including opportunistic infection, an… more
Abstract:DESCRIPTION (provided by applicant): The laboratory rat is the preferred rodent model in pre-clinical drug studies and encompasses the bulk of accumulated knowledge in drug development. Their larger size facilitates procedures otherwise difficult in mice,including studies using instrumentation,… more
Abstract:nGimat & Oak Ridge National Labs jointly propose to develop safe high-voltage cathode materials for pulsed power applications in the military and commercial sectors. nGimat's versatile NanoSpray Combustion process will be utilized to tailor the bulk & surface composition of the cathode… more
Abstract:AMT Nano, LLC has developed innovative technology for achieving a versatile microrobot platform. The innovation relies on a unique micromolding process, which is low-cost and high-throughput, and high precison. The process achieves versatility by generating deterministic freeform shapes in polymers… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project aims to develop a new method and reactor for continuous and large-scale production of titania and other related metal oxide nanowires. Inexpensive micron scale metal oxide and spherically shaped powders will be converted to nanowires… more
Abstract:DESCRIPTION (provided by applicant): The World Health Organization estimates that over 350 million people are at risk of developing leishmaniasis and infection prevalence is 14 million people in the world. Annually, 2 million people are infected with Leishmania species and 270,000 will die.… more
Abstract:DESCRIPTION (provided by applicant): Over 250,000 new cases of head and neck cancers (HNCs) and non-small cell lung cancers (NSCLCs) are diagnosed every year in the United States. At the time of diagnosis, 60% of these cases are regionally advanced (stageIII and IV). Wide surgical excision is not… more
Abstract:DESCRIPTION (provided by applicant): Sleep apnea is a common respiratory disorder during sleep, which has significant individual, healthcare system, and societal impact. The current gold standard method for sleep apnea assessment is full night polysomnography (PSG). However, its high cost,… more
Abstract:DESCRIPTION (provided by applicant): Medication errors are now the leading cause of accidental death. Smart electronic devices are emerging to aid medication adherence with organizing, reminding, monitoring, and communicating medication use. Most are focused on bulk pills and are structured to… more
Abstract:Longhurst Engineering, PLC and Vanderbilt University propose the innovation of torque control of friction stir welding (FSW) as a replacement to force control of FSW. The value of the torque is significant because it indicates how far the tool is plunged into the work piece. Proper engagement of… more
Abstract:DESCRIPTION (provided by applicant): The Fontan procedure is currently standard care for patients with complex single ventricle congenital heart defects. The Fontan procedure involves the creation of a cavopulmonary (CP) shunt connecting the inferior and superior vena cava (IVC and SVC) directly to… more
Abstract:This Small Business Innovation Research Phase I project will study the feasibility of a novel contaminant-tolerant solvent/stripping chemical hybrid process for post-combustion CO2 capture from utility flue gas. The process will use a proprietary solvent technology to achieve DOEs goal of 90% or… more
Abstract:Certain types of specialty peppers may be desired by chefs. Capsicum baccatum, a relative of peppers commonly grown in the U.S. A, is a diverse species; both wild and cultivated forms occur in South America. However, cultivation of C. baccatum outside of South America is rare, and little scientific… more
Abstract:DESCRIPTION (provided by applicant): There is a significant unmet medical need to provide additional pharmacologic treatments for treatment and prevention of opioid overdose. This Fast Track STTR project proposes to apply drug delivery technologies to develop a novel use for a nasally delivered… more
Abstract:ABSTRACT: For this SBIR Proposal, NOHMs Technology will design a safe, non-flammable, dendrite-suppressing electrolyte from a family of unique class of self-suspended hybrid nanoparticles for use in Li-S batteries. The three electrolytes to be explored are: (1) NOHMs Electrolyte, (2) NOHMs… more
Abstract:The airborne network suffers from the limitations of highly constrained network capacity due to wireless link communication and intermittent connectivity among platforms. Information coding theory is a very new technology that is initially proposed for computer networks in 2001 and for ad hoc… more
Abstract:DESCRIPTION (provided by applicant): For such life-changing impact that bariatric surgery represents for obesity, this popular procedure is noted for its poor post- operative follow-up rates and outcomes tracking. Laparoscopic Gastric Bypass (LGB) has emer
ged as one of the most popular surgical… more
Abstract:DESCRIPTION (provided by applicant): Vitamin D plays a critical role in calcium metabolism and bone health in children and adults. It is now recognized that every tissue and cell in the body have a vitamin D receptor and thus every tissue and cell in the b
ody is a target for vitamin D action.… more
Abstract:DESCRIPTION (provided by applicant): The present lack of blood-based diagnosis requires AD patients to be subjected to either invasive spinal fluid (CSF) tapping, expensive MRI or PET imaging, or arduous psychological testing, all unsuitable and costly for
our elderly. Strategically, we shall… more
Abstract:To overcome the obstacles that previous researchers have been unable to surpass, Talon Technologies has developed a unique hose system that builds on proven high pressure designs. Talon has experience with designing high pressure hoses and understands the challenges facing this project. The concept… more
Abstract:This SBIR Phase I project will develop a biodegradable fabric "pod" for use in reforestation of areas after fires or logging. The company is applying it's expertise in fiber weaving to manufacture an innovative device that allows the growth of seedlings on top of the soil and eliminates the need… more
Abstract:This SBIR project aims at the development of an innovative technology that can be attached to existing submerged arc welding (SAW) systems to monitor and feedback control the depth of weld penetration. Existing SAW systems will be operated using existing welding procedures without modifications. In… more
Abstract:The aluminum alloys have low density, relatively high strength, and high strength-to-weight ratio, which brings some major advantages in marine structure design, fabrication, and operations. However, marine ships are subjected to a complex and severe loading, and the typical failure mode of aluminum… more
Abstract:Research is proposed for the development and implementation of state of the art computational and experimental tools for the investigation of the impact of control surface freeplay on the flutter and limit cycle oscillation characteristics of two-dimensional and three-dimensional wings in subsonic… more
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