Abstract:The proposed research program aims at developing a variable-fidelity software tool set for aeroservothermoelastic-propulsive (ASTE-P) modeling that can be routinely applied to the design of aerospace vehicles. The toolset can be applied to conventional vehicle types as well as hypersonic vehicles.… more
Abstract:DESCRIPTION (provided by applicant): A high percentage of the ~ 470,000 children born prematurely each year in the US require intravenous feeding after birth because they do not tolerate oral feeding. This is accomplished with a total parenteral nutrition
(TPN) solution, which is prepared from… more
Abstract:This Small Business Innovation Research (SBIR) Phase I research project aims to develop a yeast-based platform for the generation of novel sesquiterpene compounds, as well as commercially unavailable sesquiterpene scaffolds. The technique combines metabolic, protein and biochemical approaches to… more
Abstract:DESCRIPTION (provided by applicant): Cervical cancer is one of the most common cancers affecting women and is a worldwide health problem. Unlike most cancers, cervical cancer is caused by a virus - the human papillomavirus (HPV). Two preventative vaccines
against HPV were recently licensed in the… more
Abstract:DESCRIPTION (provided by applicant): The objective of this NIAID Advanced STTR Phase I proposal is to combine the strengths of academic investigators from the fields of immunology and animal disease modeling with the resources of ApoImmune Inc. to develop
a novel vaccine, ApoVax104-TB targeting… more
Abstract:Aluminum alloys are known to suffer from Stress Corrosion Cracking(SCC). SCC of high strength alloys can proceed rapidly, and can lead to devastating structural failures. However, a solid understanding of combined interactions of metallurgical, environmental and mechanical factors surrounding the… more
Abstract:Connecting deep submergence systems (submarines) in the field can be a dangerous and difficult task. The rigid piping systems used today have little flexibility to accommodate for variations in connection points and differences in tolerances between vessels. Atkins & Pearce, a 200 year old… more
Abstract:DESCRIPTION (provided by applicant): We are proposing to develop a new treatment for targeting and eliminating glioblastoma multiforme (GBM, high grade glioma), a deadly and invasive brain tumor with no effective treatment. Of the 12,000 patients expected
to be diagnosed with GBM this year, most… more
Abstract:DESCRIPTION (provided by applicant): Carcinoma of the pancreas is the 4th leading cause of cancer deaths. The American Cancer Society has estimated 37,170 new cases and 33,370 deaths in 2007. The cancer generally develops without early symptoms and most pa
tients present to treating physicians with… more
Abstract:DESCRIPTION (provided by applicant): Otitis media is a common childhood disease with annual direct costs estimated to exceed 3 billion. Otitis media is the most frequent cause of pediatric practitioner visits and results in more than 20 million antibiotic
prescriptions annually. However, the… more
Abstract:DESCRIPTION (provided by applicant): Urinary tract infections (UTIs) are very common bacterial infections that affect millions of people each year. In the U.S., approximately 10% of women are diagnosed with cystitis annually, with an associated cost of 1.
6 billion. UTIs are also the most commonly… more
Abstract:DESCRIPTION (provided by applicant): This Phase II SBIR project proposes to develop an electrical stimulation augmented exercise device for individuals with incomplete spinal cord injury (iSCI). The device will provide a closed-chain, load bearing lower
extremity exercise that has the potential… more
Abstract:DESCRIPTION (provided by applicant): Recovery of independent locomotion is among the most significant therapeutic aims following incomplete spinal cord injury (iSCI) and may lead to dramatic improvements in quality of life for the affected individual as we
ll as dramatic cost savings to both the… more
Abstract:DESCRIPTION (provided by applicant): Recovery of quadriceps muscle force following post-surgical knee immobilization is a significant therapeutic aim which is associated with quality of gait and the ability to perform activities of daily living. Several st
udies from various research groups have… more
Abstract:This Small Business Technology Transfer Research (STTR) project will develop a novel real-time depth sensor that exploits the inverse square law, e.g., the light radiance falls off as a function of distance. Compared to existing commercial full-frame sensors, it is expected to provide high… more
Abstract:DESCRIPTION (provided by applicant): Tissue and organ transplantation procedures save and/or improve the lives of hundred of thousands of patients annually in the US. The goal of this research is to develop a local anti-complement therapy for donor organ e
x vivo application that will reduce… more
Abstract:This SBIR Phase II project will develop and deliver a software media architecture that removes a critical barrier to the widespread use of multi-projector, high-resolution, ultra definition displays. The approach defines a set of layered abstractions from the low-level display driver to higher-level… more
Abstract:DESCRIPTION (provided by applicant): Alcohol abuse, dependence, and related societal effects exert a tremendous toll on world-wide and American health and economics. Given this devastating impact, the significant lack of pharmaceutical intervention, even f
or those patients seeking treatment, is… more
Abstract:DESCRIPTION (provided by applicant): The total cost of caring for Parkinson's disease is about 25 billion per year in the United States. There is an urgent and unmet need for an effective treatment for the patients who have suffered debilitating loss of n
eurons and motor function. Development of… more
Abstract:The Small Business Innovation Research (SBIR) Phase I project will utilize highly processed fly ash in combination with the stir-casting technology to advance the manufacturing of coal ash-aluminum metal matrix composites (MMC). Fly ash, a ceramic glass sphere is produced when coal is burned, will… more
Abstract:Insects are major pests of economically important plant-based food and fiber crops and also vector diseases causing millions of human deaths and untold suffering annually. Moreover, our efforts to control insect pests have caused massive environmental contamination and continue to cause human and… more
Abstract:DESCRIPTION (provided by applicant): Warfarin is the most commonly used oral anticoagulant medication. Because an individual's proper warfarin dose is difficult to assess, most physicians initiate therapy at a standard dose and follow up with an INR blood
test to ensure the medicine is working… more
Abstract:DESCRIPTION (provided by applicant): The purpose of this Phase II STTR project is to develop a nanoparticle-based drug delivery system for use in the treatment of dry age-related macular degeneration (AMD). AMD is the leading cause of blindness for individ
uals over fifty-five years of age that live… more
Abstract:DESCRIPTION (provided by applicant): Sickle Cell Disease (SCD) is a genetic abnormality of red blood cells (RBC) that affects over 70,000 people in the United States, or approximately 1 in every 500 African-Americans. With current therapies, the mortality
in the United States is 50% by age 40. SCD… more
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