Abstract:DESCRIPTION (provided by applicant): The long-term objective of this project is to develop validated, genetic biomarkers to aid in more accurate diagnosis and targeted treatment of schizophrenia and related neuropsychiatric illnesses, including bipolar di
sorder. In Phase I, SureGene demonstrated… more
Abstract:This award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5). This Small Business Innovation Research (SBIR) Phase II project seeks to reduce the cost and risk of manufacturing nanoparticle/resin blends for coatings. Currently nanocoating resin manufacturing… more
Abstract:DESCRIPTION (provided by applicant): The outcome of this SBIR application will be a rat model of colorectal cancer (CRC), which can be used to discover new targets for colon cancer therapy. CRC rats will be produced using Transposagen's novel technology fo
r introducing somatic mutations in rats. A… more
Abstract:DESCRIPTION (provided by applicant): This project aims to rapidly produce rat mutants through a transposon-based method of mutagenesis. The rat is a favored model for many types of human disease for which mice are not suitable. The rat is the most relevant
model for cardiovascular and hypertension… more
Abstract:This Small Business Innovation Research (SBIR) Phase II project addresses the development of a UV curable bulk nanocomposite having enhanced optical and mechanical properties for ophthalmic lenses. The work focuses the incorporation of metal oxide nanoparticles into a transparent polymer to engineer… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project tests the feasibility of using a highly innovative polarized multi-wavelength light extinction spectroscopy approach for on-line non-destructive characterization of coated nanoparticles and nanoparticle agglomerates. From extinction… more
Abstract:This SBIR Phase I project is to prove the feasibility of an innovative weld monitoring technology. This innovative technology is characterized by (1) an innovative non-transferred arc sensor which responds to both surface conductivity and sensor-to-joint distance and can be used to monitor the joint… more
Abstract:Gas Metal Arc Welding (GMAW) is the most widely used welding process. It is also the major process used in shipbuilding. In traditional GMAW and all its modifications, the current which melts the wire is the same as the current which heats the base metal. The base metal heat input is thus… more
Abstract:Orbital pipe welding systems are not true emulation of skilled welders who adjust welding parameters based on observation on the weld pool. This SBIR Phase II project aims at the development of commercial prototype systems which can adaptively adjust welding parameters based on an observation on the… more
Abstract:The objective of the proposed research aims to develop Reduced Order Models (ROMs) (i.e. POD, HB, combined POD and HB) based upon flight data to better predict the aircraft aeroelastic response at next flight condition, e.g. higher Mach number. By incorporating flight test data and using the… more
Abstract:CFD modeling and simulation has been heavily invested in decades of manpower by a large community of researchers. However, the excessive numerical diffusion inherently caused by discretization errors plus the possibly largest/finest grid requirement for rotor wake modeling prevents CFD to be… more
Abstract:This SBIR aims at developing a high-fidelity, yet efficient and easy-to-use, composite rotor blade and wing section design environment to facilitate rapid and confident aeromechanics assessment during conceptual design stages. A well-known technical barrier for composite rotor blade and wing section… more
Abstract:The proposed research program aims at developing a variable-fidelity software tool set for aeroservothermoelastic-propulsive (ASTE-P) modeling that can be routinely applied to the design of aerospace vehicles. The toolset can be applied to conventional vehicle types as well as hypersonic vehicles.… more
Abstract:DESCRIPTION (provided by applicant): A high percentage of the ~ 470,000 children born prematurely each year in the US require intravenous feeding after birth because they do not tolerate oral feeding. This is accomplished with a total parenteral nutrition
(TPN) solution, which is prepared from… more
Abstract:This Small Business Innovation Research (SBIR) Phase I research project aims to develop a yeast-based platform for the generation of novel sesquiterpene compounds, as well as commercially unavailable sesquiterpene scaffolds. The technique combines metabolic, protein and biochemical approaches to… more
Abstract:DESCRIPTION (provided by applicant): Cervical cancer is one of the most common cancers affecting women and is a worldwide health problem. Unlike most cancers, cervical cancer is caused by a virus - the human papillomavirus (HPV). Two preventative vaccines
against HPV were recently licensed in the… more
Abstract:DESCRIPTION (provided by applicant): The objective of this NIAID Advanced STTR Phase I proposal is to combine the strengths of academic investigators from the fields of immunology and animal disease modeling with the resources of ApoImmune Inc. to develop
a novel vaccine, ApoVax104-TB targeting… more
Abstract:Aluminum alloys are known to suffer from Stress Corrosion Cracking(SCC). SCC of high strength alloys can proceed rapidly, and can lead to devastating structural failures. However, a solid understanding of combined interactions of metallurgical, environmental and mechanical factors surrounding the… more
Abstract:Connecting deep submergence systems (submarines) in the field can be a dangerous and difficult task. The rigid piping systems used today have little flexibility to accommodate for variations in connection points and differences in tolerances between vessels. Atkins & Pearce, a 200 year old… more
Abstract:DESCRIPTION (provided by applicant): We are proposing to develop a new treatment for targeting and eliminating glioblastoma multiforme (GBM, high grade glioma), a deadly and invasive brain tumor with no effective treatment. Of the 12,000 patients expected
to be diagnosed with GBM this year, most… more
Abstract:DESCRIPTION (provided by applicant): Carcinoma of the pancreas is the 4th leading cause of cancer deaths. The American Cancer Society has estimated 37,170 new cases and 33,370 deaths in 2007. The cancer generally develops without early symptoms and most pa
tients present to treating physicians with… more
Abstract:DESCRIPTION (provided by applicant): Otitis media is a common childhood disease with annual direct costs estimated to exceed 3 billion. Otitis media is the most frequent cause of pediatric practitioner visits and results in more than 20 million antibiotic
prescriptions annually. However, the… more
Abstract:DESCRIPTION (provided by applicant): Urinary tract infections (UTIs) are very common bacterial infections that affect millions of people each year. In the U.S., approximately 10% of women are diagnosed with cystitis annually, with an associated cost of 1.
6 billion. UTIs are also the most commonly… more
Abstract:DESCRIPTION (provided by applicant): This Phase II SBIR project proposes to develop an electrical stimulation augmented exercise device for individuals with incomplete spinal cord injury (iSCI). The device will provide a closed-chain, load bearing lower
extremity exercise that has the potential… more
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