Abstract:DESCRIPTION (provided by applicant): Recovery of independent locomotion is among the most significant therapeutic aims following incomplete spinal cord injury (iSCI) and may lead to dramatic improvements in quality of life for the affected individual as we
ll as dramatic cost savings to both the… more
Abstract:DESCRIPTION (provided by applicant): Recovery of quadriceps muscle force following post-surgical knee immobilization is a significant therapeutic aim which is associated with quality of gait and the ability to perform activities of daily living. Several st
udies from various research groups have… more
Abstract:This Small Business Technology Transfer Research (STTR) project will develop a novel real-time depth sensor that exploits the inverse square law, e.g., the light radiance falls off as a function of distance. Compared to existing commercial full-frame sensors, it is expected to provide high… more
Abstract:DESCRIPTION (provided by applicant): Tissue and organ transplantation procedures save and/or improve the lives of hundred of thousands of patients annually in the US. The goal of this research is to develop a local anti-complement therapy for donor organ e
x vivo application that will reduce… more
Abstract:Despite the importance of jet fighter afterburner designs, there exists very little data on the majority of the individual components of jet fuel, especially JP-8, to enable development of a detailed kinetic mechanism. Although the Multi University Research Initiative program has been initiated for… more
Abstract:Since 1990, the cost of hydrogen needed to treat one barrel of oil has increased from 10 cents to $1. This problem is being exacerbated because of stricter environmental regulations and because the crude now being processed by refiners contains less hydrogen and more sulfur. To deal with the… more
Abstract:It is fairly assumed that if a substitute for natural gas is not found, energy intensive industries such as glass, cement, and steel will suffer irreparable damage, with higher unemployment and lower productivity for the U.S. economy. Amongst many alternatives, inexpensive small-and-medium-scale… more
Abstract:This SBIR Phase II project will develop and deliver a software media architecture that removes a critical barrier to the widespread use of multi-projector, high-resolution, ultra definition displays. The approach defines a set of layered abstractions from the low-level display driver to higher-level… more
Abstract:DESCRIPTION (provided by applicant): Alcohol abuse, dependence, and related societal effects exert a tremendous toll on world-wide and American health and economics. Given this devastating impact, the significant lack of pharmaceutical intervention, even f
or those patients seeking treatment, is… more
Abstract:DESCRIPTION (provided by applicant): The total cost of caring for Parkinson's disease is about 25 billion per year in the United States. There is an urgent and unmet need for an effective treatment for the patients who have suffered debilitating loss of n
eurons and motor function. Development of… more
Abstract:The Small Business Innovation Research (SBIR) Phase I project will utilize highly processed fly ash in combination with the stir-casting technology to advance the manufacturing of coal ash-aluminum metal matrix composites (MMC). Fly ash, a ceramic glass sphere is produced when coal is burned, will… more
Abstract:Insects are major pests of economically important plant-based food and fiber crops and also vector diseases causing millions of human deaths and untold suffering annually. Moreover, our efforts to control insect pests have caused massive environmental contamination and continue to cause human and… more
Abstract:DESCRIPTION (provided by applicant): Warfarin is the most commonly used oral anticoagulant medication. Because an individual's proper warfarin dose is difficult to assess, most physicians initiate therapy at a standard dose and follow up with an INR blood
test to ensure the medicine is working… more
Abstract:DESCRIPTION (provided by applicant): The purpose of this Phase II STTR project is to develop a nanoparticle-based drug delivery system for use in the treatment of dry age-related macular degeneration (AMD). AMD is the leading cause of blindness for individ
uals over fifty-five years of age that live… more
Abstract:DESCRIPTION (provided by applicant): Sickle Cell Disease (SCD) is a genetic abnormality of red blood cells (RBC) that affects over 70,000 people in the United States, or approximately 1 in every 500 African-Americans. With current therapies, the mortality
in the United States is 50% by age 40. SCD… more
Abstract:DESCRIPTION (provided by applicant): SCR, Inc. (Louisville, KY) has developed a long-term implantable counterpulsation device (CPD) to treat heart failure (HF) patients who may be responsive to a milder form of cardiac assist. The CPD is 32-ml stroke vol
ume, valveless pneumatically-driven blood… more
Abstract:DESCRIPTION (provided by applicant): Project Summary: In Phase I we developed a model system and a prototype Salt Sensitivity Assay to establish proof-of-principle . In Phase II we propose the evaluation of the prototype that will quantitatively
measure our biomarker in the target… more
Abstract:DESCRIPTION (provided by applicant): There are no FDA approved pharmacological therapies for the acute treatment of traumatic brain injury (TBI) that mitigate damaging neurological effects. However, the potential for effective pharmacological intervention
exists in that a majority of post-traumatic… more
Abstract:This Small Business Innovative Research Phase I project demonstrates the feasibility of a device for rapidly determining the susceptibility of infectious bacteria to antibiotic treatments. Whereas standard susceptibility tests take between 24-96 hours, this device promises to provide assessments in… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project will reduce the cost and risk of manufacturing nanoparticle-containing coatings. Metal and metal oxide nanoparticle-polymer compositions are becoming more important in a number of fields, including pharmaceuticals, materials, sensors and… more
Abstract:Section 306 of the Public Health Security and Bioterrorism Preparedness and Response Act, known as 'the Bioterrorism Act', requires the establishment and maintenance of records that allow for the identification of the immediate previous sources and the immediate subsequent recipients of food. These… more
Abstract:This Small Business Innovation Research Phase I project will develop a nanocomposite ophthalmic lens utilizing nanoparticles and UV curable monomers. The objectives are to increase the impact resistance of the lens by 33% and to improve the modulus at elevated temperatures keeping haze to 1% or less… more
Abstract:The proposed research program aims at developing a variable-fidelity software tool set for aeroservothermoelastic-propulsive (ASTE-P) modeling that can be routinely applied to the design of aerospace vehicles. The tool set can be applied to conventional vehicle types as well as hypersonic vehicles.… more
Abstract:The proposed research program aims to develop a physics-based identification, modeling and management infrastructure for aeroelastic limit-cycle oscillations. This infrastructure will be built upon high fidelity state-of-the-art theoretical/computational methods as validated and verified by… more
Abstract:DESCRIPTION (provided by applicant): Type 1 Diabetes (T1D) is an autoimmune disease that targets insulin secreting pancreatic beta cells for destruction and remains a major cause of morbidity and mortality in over 1% of the population worldwide. Although i
nsulin therapy and islet transplantation… more
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