Abstract:DESCRIPTION (provided by applicant): The main objective of this proposal is to develop a novel cancer vaccine, ApoVax-SVN(tm) based on the use of a proprietary costimulatory chimeric ligand, 4-1BBL, designed to specifically deliver survivin, a tumor associ
ated antigen (TAA) to professional… more
Abstract:DESCRIPTION (provided by applicant): Various cancer vaccines based on tumor associated antigens (TAAs) or tumor specific antigens (TSAs) have shown efficacy in preclinical models. However, their therapeutic efficacies have been rather limited in clinical
trial settings. Although the reason for… more
Abstract:DESCRIPTION (provided by applicant): The American Cancer Society estimated a total of 1,372,910 new cancer cases and 570,280 cancer deaths in the U. S. in 2005. The National Cancer Institute solicits research proposals to develop cancer treatments via the
Small Business Innovation Research funding… more
Abstract:DESCRIPTION (provided by applicant): Among the most significant goals of therapeutic exercise following stroke are maintaining strength and endurance of paretic muscles and aiding in restoration of functional use of the affected limbs. One relatively new
and promising device that may address these… more
Abstract:DESCRIPTION (provided by applicant): Recovery of quadriceps muscle force following post-surgical knee immobilization is a significant therapeutic aim which is associated with quality of gait and the ability to perform activities of daily living. Several st
udies from various research groups have… more
Abstract:This Small Business Technology Transfer (STTR) Phase I project will provide a commercial solution to click fraud identification and prevention. The current existing solutions can not detect the so-called software click. This STTR project proposes a real time collaborative click fraud detection and… more
Abstract:This Small Business Innovation Research (SBIR) Phase II project proposes to develop a new process employing the superadiabatic reverse flow reactor to reform hydrogen sulfide into hydrogen with the simultaneous recovery of sulfur. Currently, the seven million tons of hydrogen sulfide produced each… more
Abstract:This Small Business Innovation Research Phase I project will develop an architecture to support the management and display of media on a new class of emerging displays. The proposed architecture is a new approach to supporting displays with the ability to 1) reconfigure themselves as different… more
Abstract:The U.S. poultry industry produces more than 45 billion pounds of poultry annually. A majority of this production is from concentrated animal feeding operations. In a modern poultry growing facility, small chicks are raised in several large houses that typically cover over 20,000 ft2.
Starting with… more
Abstract:DESCRIPTION (provided by applicant): There is an urgent and unmet need for effective treatment methods for stroke patients who have suffered debilitating loss of nervous tissue and neural function. Development of neuroregeneration therapy is an important g
oal because neurological disorders such as… more
Abstract:DESCRIPTION (provided by applicant): The long-term goal of our program is to develop safe and effective techniques to combat tissue damage caused by ischemia. The specific aims of this proposal are to investigate high-energy phosphate contents in human non
-healing chronic wounds, to further improve… more
Abstract:DESCRIPTION (provided by applicant): Global cancer rates are predicted to increase by 50% to 15 million by 2020. Treatments depend on early detection and identification to select the most effective therapies to end the suffering and loss of life. Biomarker
s offer tremendous potential for early… more
Abstract:DESCRIPTION (provided by applicant): PGXL Laboratories has access to a unique computational tool that can significantly reduce the morbidity and mortality associated with warfarin anticoagulation therapy. This project will yield a web-based software tool
that will, for the first time, allow… more
Abstract:DESCRIPTION (provided by applicant): The incidence of congestive heart failure (CHF) is increasing worldwide with over one million new cases diagnosed annually. Over the past 30 years, counterpulsation with an intra-aortic balloon pump (IABP) has been wide
ly and successfully used as a short-term… more
Abstract:DESCRIPTION (provided by applicant): In many aspects the rat is a better animal model than the mouse for functional genomic studies. The physiology and drug metabolism of rats and humans are more similar than that of mice and humans. The rat is larger than
the mouse, making many studies easier to… more
Abstract:Orbital pipe welding systems can function like skilled welders, to certain extent, who can move the torch very smoothly/evenly. However, their adjustment of welding parameters is not a true emulation of skilled welders who observe the weld pool and adjust welding parameters based on the observation… more
Abstract:DESCRIPTION (provided by applicant): Assenti LLC is a 10-person start-up company formed out of collaborative research teams from the University of Louisville's Speed School of Engineering and the Department of Ophthalmology & Visual Sciences along with key industry partners. Assenti's enclosed SBIR… more
Abstract:DESCRIPTION (provided by applicant): Oral candidiasis (oropharyngeal candidosis or thrush) is a common infection in immunosuppressed individuals, and, if not blunted, can transit to esophageal candidosis or life-threatening candidemia. These potentially life-threatening fungal infections originate… more
Abstract:DESCRIPTION (provided by applicant): Irritant and allergic contact dermatitis affect approximately 10% of adults, and hand eczema represents one of the four most common occupationally related diseases, accounting for substantial lost earning potential in otherwise healthy populations. Both irritant… more
Abstract:DESCRIPTION (provided by applicant): The goal of this project is to develop a safe biocidal vaginal gel for treatment of vulvovaginal candidiasis (WC). WC is caused by one of several airborne species of the yeast Candida that are normal inhabitants of humans at several sites, including the vagina. C… more
Abstract:DESCRIPTION (provided by applicant): This project proposes to develop an electrical stimulation augmented exercise device for individuals with incomplete spinal cord injury (iSCI). The device will provide a closed-chain, load bearing lower extremity exercise that has the potential to increase muscle… more
Abstract:DESCRIPTION (provided by applicant): Thousands of people every year experience long-term or lifelong disabilities in motor, sensory, and cognitive function as result of central nervous system (CNS) injuries. There has been little hope for recovery from these dysfunctions because axons from injured… more
Abstract:This SBIR Phase I project will bring together research in biometrics and information systems by developing new techniques that learn and then continuously monitor a user's biometric features locally, freeing the information system from the task of managing identities or participating in the… more
Abstract:DESCRIPTION (provided by applicant): The overall goal of this project is to develop a retina implantation instrument kit that will allow: 1) retinal surgeons to harvest, dissect, and transplant sheets of undifferentiated fetal retinal tissue with its retinal pigment epithelium (RPE) and then… more
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