Abstract:DESCRIPTION (provided by applicant): Sickle Cell Disease (SCD) is a genetic abnormality of red blood cells (RBC) that affects over 70,000 people in the United States, or approximately 1 in every 500 African-Americans. With current therapies, the mortality
in the United States is 50% by age 40. SCD… more
Abstract:DESCRIPTION (provided by applicant): SCR, Inc. (Louisville, KY) has developed a long-term implantable counterpulsation device (CPD) to treat heart failure (HF) patients who may be responsive to a milder form of cardiac assist. The CPD is 32-ml stroke vol
ume, valveless pneumatically-driven blood… more
Abstract:DESCRIPTION (provided by applicant): Project Summary: In Phase I we developed a model system and a prototype Salt Sensitivity Assay to establish proof-of-principle . In Phase II we propose the evaluation of the prototype that will quantitatively
measure our biomarker in the target… more
Abstract:DESCRIPTION (provided by applicant): There are no FDA approved pharmacological therapies for the acute treatment of traumatic brain injury (TBI) that mitigate damaging neurological effects. However, the potential for effective pharmacological intervention
exists in that a majority of post-traumatic… more
Abstract:This Small Business Innovative Research Phase I project demonstrates the feasibility of a device for rapidly determining the susceptibility of infectious bacteria to antibiotic treatments. Whereas standard susceptibility tests take between 24-96 hours, this device promises to provide assessments in… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project will reduce the cost and risk of manufacturing nanoparticle-containing coatings. Metal and metal oxide nanoparticle-polymer compositions are becoming more important in a number of fields, including pharmaceuticals, materials, sensors and… more
Abstract:Section 306 of the Public Health Security and Bioterrorism Preparedness and Response Act, known as 'the Bioterrorism Act', requires the establishment and maintenance of records that allow for the identification of the immediate previous sources and the immediate subsequent recipients of food. These… more
Abstract:This Small Business Innovation Research Phase I project will develop a nanocomposite ophthalmic lens utilizing nanoparticles and UV curable monomers. The objectives are to increase the impact resistance of the lens by 33% and to improve the modulus at elevated temperatures keeping haze to 1% or less… more
Abstract:The proposed research program aims at developing a variable-fidelity software tool set for aeroservothermoelastic-propulsive (ASTE-P) modeling that can be routinely applied to the design of aerospace vehicles. The tool set can be applied to conventional vehicle types as well as hypersonic vehicles.… more
Abstract:The proposed research program aims to develop a physics-based identification, modeling and management infrastructure for aeroelastic limit-cycle oscillations. This infrastructure will be built upon high fidelity state-of-the-art theoretical/computational methods as validated and verified by… more
Abstract:DESCRIPTION (provided by applicant): Type 1 Diabetes (T1D) is an autoimmune disease that targets insulin secreting pancreatic beta cells for destruction and remains a major cause of morbidity and mortality in over 1% of the population worldwide. Although i
nsulin therapy and islet transplantation… more
Abstract:DESCRIPTION (provided by applicant): The main objective of this proposal is to develop a novel cancer vaccine, ApoVax-SVN(tm) based on the use of a proprietary costimulatory chimeric ligand, 4-1BBL, designed to specifically deliver survivin, a tumor associ
ated antigen (TAA) to professional… more
Abstract:DESCRIPTION (provided by applicant): Various cancer vaccines based on tumor associated antigens (TAAs) or tumor specific antigens (TSAs) have shown efficacy in preclinical models. However, their therapeutic efficacies have been rather limited in clinical
trial settings. Although the reason for… more
Abstract:DESCRIPTION (provided by applicant): The American Cancer Society estimated a total of 1,372,910 new cancer cases and 570,280 cancer deaths in the U. S. in 2005. The National Cancer Institute solicits research proposals to develop cancer treatments via the
Small Business Innovation Research funding… more
Abstract:DESCRIPTION (provided by applicant): Among the most significant goals of therapeutic exercise following stroke are maintaining strength and endurance of paretic muscles and aiding in restoration of functional use of the affected limbs. One relatively new
and promising device that may address these… more
Abstract:DESCRIPTION (provided by applicant): Recovery of quadriceps muscle force following post-surgical knee immobilization is a significant therapeutic aim which is associated with quality of gait and the ability to perform activities of daily living. Several st
udies from various research groups have… more
Abstract:This Small Business Technology Transfer (STTR) Phase I project will provide a commercial solution to click fraud identification and prevention. The current existing solutions can not detect the so-called software click. This STTR project proposes a real time collaborative click fraud detection and… more
Abstract:This Small Business Innovation Research (SBIR) Phase II project proposes to develop a new process employing the superadiabatic reverse flow reactor to reform hydrogen sulfide into hydrogen with the simultaneous recovery of sulfur. Currently, the seven million tons of hydrogen sulfide produced each… more
Abstract:This Small Business Innovation Research Phase I project will develop an architecture to support the management and display of media on a new class of emerging displays. The proposed architecture is a new approach to supporting displays with the ability to 1) reconfigure themselves as different… more
Abstract:The U.S. poultry industry produces more than 45 billion pounds of poultry annually. A majority of this production is from concentrated animal feeding operations. In a modern poultry growing facility, small chicks are raised in several large houses that typically cover over 20,000 ft2.
Starting with… more
Abstract:DESCRIPTION (provided by applicant): There is an urgent and unmet need for effective treatment methods for stroke patients who have suffered debilitating loss of nervous tissue and neural function. Development of neuroregeneration therapy is an important g
oal because neurological disorders such as… more
Abstract:DESCRIPTION (provided by applicant): The long-term goal of our program is to develop safe and effective techniques to combat tissue damage caused by ischemia. The specific aims of this proposal are to investigate high-energy phosphate contents in human non
-healing chronic wounds, to further improve… more
Abstract:DESCRIPTION (provided by applicant): Global cancer rates are predicted to increase by 50% to 15 million by 2020. Treatments depend on early detection and identification to select the most effective therapies to end the suffering and loss of life. Biomarker
s offer tremendous potential for early… more
Abstract:DESCRIPTION (provided by applicant): PGXL Laboratories has access to a unique computational tool that can significantly reduce the morbidity and mortality associated with warfarin anticoagulation therapy. This project will yield a web-based software tool
that will, for the first time, allow… more
Abstract:DESCRIPTION (provided by applicant): The incidence of congestive heart failure (CHF) is increasing worldwide with over one million new cases diagnosed annually. Over the past 30 years, counterpulsation with an intra-aortic balloon pump (IABP) has been wide
ly and successfully used as a short-term… more
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