Abstract:This project proposes to study the core concepts of Active Conceptual modeling (A-CM) with applications to military and commercial systems. We plan to explore the feasibility of extending the mathematical framework for Entity-Relationship (ER)-based active conceptual modeling developed by Dr. Peter… more
Abstract:DESCRIPTION (provided by applicant): The object of the proposed research is to conduct a Phase 1 clinical trial with 4-demethyl-cholesteryloxycarbonylpenclomedine (DM-CHOC-PEN), a carbonate derivative of 4-demethyl-penclomedine (DM-PEN) in patients with ad
vanced cancer. The latter is the antitumor… more
Abstract:The objective of this project is to optimize the design of a microwave interference scanning system and application procedure for use in the Ceramic Matrix Composite (CMC) manufacturing process. Quick, efficient in-process measurement of part porosity will be an integral part of pyrolysis cycle… more
Abstract:The objective of the program is to develop and demonstrate a new lightweight, low-pressure drop, low cost, high heat transfer heat exchanger material for military vehicles. Mezzo Technologies of Baton Rouge, Louisiana designs and manufactures heat exchangers whose design is fundamentally different… more
Abstract:The Expeditionary Fighting Vehicle (EFV) currently is extremely noisy. The goal of the proposal is to reduce noise produced by the cooling system for the engine, which consists of fans,heat exchangers, and ducting to the outside. Mezzo is developing mirco tube heat exchangers that provide a much… more
Abstract:Mezzo Technologies designs and fabricates micro channel heat exchangers that offer high performance in non phase change applications (gas-gas, liquid-liquid, and gas-liqid). The potential exists or Mezzo's heat exchangers to also provide excellent performance in applications involving phase change… more
Abstract:DESCRIPTION (provided by applicant): Myocardial infarct continues to be a major problem affecting a large number of adults. In a series of small animal experiments, it has been shown that application of hypothermia to the compromised heart is beneficial in
reducing infarct size. If the heart is… more
Abstract:This Phase II project has two technical goals. In Year 1 the focus is on increasing the video quality (bit rate) of NFT delivered broadcasts, while keeping bandwidth costs low. In Year 2 the focus shifts to expanding product support to Mac and other non-Windows systems. Network Foundation… more
Abstract:This project researches the feasibility of creating a self-powered buoy system. The technology being investigated is a means of efficiently extracting energy from ocean wave dynamics. The mechanics of ocean waves is such that they contain significant energy in the water motion and pressure changes… more
Abstract:DESCRIPTION (provided by applicant): This Phase II program intends to continue to develop an improved brachytherapy delivery system for treatment of lung cancer by incorporating radioactive 169Ytterbium sources into surgical staples used in lung resect
ion. For patients with compromised… more
Abstract:DESCRIPTION (provided by applicant): The overall objective of this Phase I program is to demonstrate the feasibility of delivering intensity modulated breast brachytherapy, permitting balloon-based breast brachytherapy to better conform to patient anatomy,
reduce potential toxicity by reducing skin… more
Abstract:DESCRIPTION (provided by applicant): HDR Brachytherapy for Intraocular Melanoma - Project Summary/Abstract The overall objective of this Phase I program is to develop a brachytherapy system for the treatment of intraocular melanoma that reduces hospitaliza
tion time, provides improved dosimetry to… more
Abstract:To provide low-cost, light-weight, cost-effective insulation system that combines an improved acoustic performance in excess of 40-60 dB with the required thermal, smoke, toxicity and fire barrier performance using mature coating technologies. Our team of acoustic and thermal experts will… more
Abstract:Commercial-scale marine aquaculture has the potential to balance the increasing demand for high-quality seafood products with the limited harvest capacity of our nations oceans. However, water reuse in recirculating aquaculture systems (RAS) is limited by the accumulation of nitrate, which can be… more
Abstract:This Small Business innovation Research (SBIR) Phase I research project aims to develop a web-based tool for the analysis of viral seqeunces. Availability of a sequence analysis tool that would help investigators manipulate viral sequences and detect contaminants would be of value to researchers as… more
Abstract:DESCRIPTION (provided by applicant): 7-butyl-10-aminocamptothecin (BACPT) and its water-soluble dipeptide pro-drug, are novel camptothecins that were designed to be used in the treatment of childhood neuroblastoma. These CPT analogs are lactones that have
increased activity in acidic hypoxia… more
Abstract:The objective of this proposal is to demonstrate the feasibility of the application of a patented microwave scanning device as an NDE technique to be used in streamlining and optimizing the Ceramic Matrix Composite (CMC) manufacturing process. The scanning process (U.S. Patent numbers 6,359,446 and… more
Abstract:The objective of this proposal is to demonstrate the feasibility of the application of a patented microwave scanning device as a portable NDE methodology to perform monitoring of the health of ceramic armor from non-projectile impacts. The scanning process utilizes microwaves as an interrogating… more
Abstract:"The goal of this project is to implement the industrial use of layer-by-layer
polyelectrolyte nanocoated pulp fibers, thereby to bring new technology to paper
making. The proposed work is based on our pioneering in the layer-by-layer
nanoassembly techniques and on our results on modification of… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project focuses on the implementation, testing, and refinement of a hybrid distributed / traditional system for broadcasting live and pre-recorded content to large online audiences at low cost. Traditional approaches to streaming media online… more
Abstract:This Small Business Innovation Research (SBIR) research project will develop a novel microcoil (or called microspring) sensing technology. Toxic proteins and bacterial pathogens pose a severe threat to the health of the general population and the military. The proof of concept experiments will be… more
Abstract:DESCRIPTION (provided by applicant): This Phase I program intends to develop an improved brachytherapy delivery system for treatment of lung cancer by incorporating radioactive 169Ytterbium sources into surgical staples used in lung resection. For patients
with compromised cardiopulmonary status,… more
Abstract:DESCRIPTION (provided by applicant): Intravenous drug administration is often clinically desired over oral administration, particularly for patients who have difficulty taking an oral drug due to their disease or condition (eg, unconsciousness, anesthetize
d). IV administration also produces a… more
Abstract:DESCRIPTION (provided by applicant): Chronically, medically resistant pain is one of the most significant health problems in our country and affects more than 50 million Americans. Neuropathic pain syndromes are for the most part resistant to traditional
analgesic treatments with NSAIDs,… more
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