Abstract:ABSTRACT: Magnolia Solar proposes to develop an innovative high-efficiency, single-junction solar cell in collaboration with Prof. Diana Huffaker and her group by utilizing multi-photon absorption processes in InAsSb/AlAsSb quantum dot structures. The proposed device structure satisfies the unique… more
Abstract:DESCRIPTION (provided by applicant): This is a Phase II SBIR proposal to increase the throughput of our DNA sequencing instrument to enable whole genome sequencing with high efficiency and accuracy for a cost of under 1000 per genome. In Phase I, we developed a working sequencing assay, a… more
Abstract:Microchannel Plate event multipliers capable of operation at cryogenic temperatures are currently not commercially available from any supplier. The proposed development of cryogenic-compatible MCPs will enable photon/electron/ion/alpha detection with high spatial resolution and sub-nanosecond event… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project will focus on the demonstration of a frequency tunable quantum cascade laser (QCL) operating at terahertz frequencies (1-10 THz) for applications including spectroscopy and non-destructive imaging. This novel source is based on external… more
Abstract:DESCRIPTION (provided by applicant): The overall goal of this project is to design a clinical protocol for the operation and monitoring of a mesenchymal stem cell (MSC)-coated dialysis device for the treatment of acute renal failure (ARF) in dogs. The project specific aims are: (1) Biomarker-guided… more
Abstract:Sentien Biotechnologies is developing cellular devices for the treatment of acute organ failure, including polytrauma-induced multiple organ dysfunction syndrome (MODS). Our flagship product, the Sentinel, is a dialyzer with mesenchymal stem cells (MSCs) seeded in the extracapillary space, designed… more
Abstract:DESCRIPTION (provided by applicant): The goal of this Phase I project is to develop a cell-coated device for the treatment of acute liver failure. The device harnesses mesenchymal stem cell secretions to provide combined anti-inflammatory and regenerativesupport. The project specific aims are: (1)… more
Abstract:ABSTRACT: This Small Business Innovation Research Phase I project seeks to develop a technology to enable broadband antireflective (AR) coatings for high-efficiency solar cells. Current, AR coatings use bilayers such as TiOx/Al2O3 that are sufficient enough to reduce reflectance losses. However,… more
Abstract:This Small Business Innovation Research (SBIR) Phase II project proposes to develop a fully functional turnkey regenerative semi-active shock absorber for heavy-duty transit buses and other commercial vehicles. An appreciable amount of energy is lost in a typical suspension as heat, especially in… more
Abstract:In this Phase 2 SBIR, we will build 3 sets of regenerative, semi-active shock absorbers, install them on a test HMMWV, and demonstrate damping, energy regeneration, and durability in a field test. The Company will advance semi-active control algorithms, and prepare the combination of mechanical… more
Abstract:Microwave oscillators based on ferrimagnetic precession and excited with a fast-rise time pulsed input have been proposed to achieve high power microwave (HPM) generation. The properties of ferrite materials utilized in such systems impose limitations on performance, including peak power capability,… more
Abstract:Metamagnetics Inc. proposes to address the limitations of currently available commercial-of-the-shelf tunable microwave filters in terms of cost, insertion loss, linearity, tuning speed, etc. by developing innovative surface mountable ferrite filter technology. The proposed concept offers the… more
Abstract:DESCRIPTION (provided by applicant): The study of retinoblastoma, a childhood tumor, has provided numerous insights into cancer biology. Perhaps most significantly, this work has revealed that cancers can develop in response to mutations in tumor suppressor genes. Tumor suppressor mutations account… more
Abstract:Lack of decontamination in the event of a FAD outbreak amplifies the spread of disease and makes the outbreak even more challenging to contain,
despite strict regulations that enforce sanitation processes. The impact that widespread disease could have on the export market is along the lines… more
Abstract:DESCRIPTION (provided by applicant): Categorical outcomes are ubiquitous in biomedical research, and generalized linear models (GLMs) represent the most widely applied methodology for testing associations between categorical variables and fixed investigative factors. Logistic regression in… more
Abstract:DESCRIPTION (provided by applicant): Market potential exists for development of works of drama that can be performed in facilities providing care for persons with dementia, and which can involve such residents interactively. Therefore, the purpose of thisPhase 2 project is to refine two plays… more
Abstract:DESCRIPTION (provided by applicant): An estimated 5.4 million Americans are currently suffering from Alzheimer's disease (AD), and AD cases are expected to rise at an alarming rate, so market potential exists for products, approaches, and/or training thatcan help treat and/or circumvent the… more
Abstract:DESCRIPTION (provided by applicant): The absence of a widely accepted commercially available method to measure glomerular filtration rate (GFR) in animal models and in the clinic has had profoundly negative effects on (i) developing methods and drugs for treating kidney disease, (ii) accurately… more
Abstract:DESCRIPTION (provided by applicant): We hypothesize that a commercially competitive magnetic nanoparticle can be developed to eliminate debris in the preparation of cell cultures, such as stem cells. Current methods to remove unwanted material from healthycultures rely on magnetic negative selection… more
Abstract:DESCRIPTION (provided by applicant): The goal of this proposal is to develop a STAT palm-sized blood counter for monitoring complete blood counts (CBC) with 3-part differential during emergencies. Changes in blood counts can reflect acutely worsening medical conditions. For instance, a rapidly… more
Abstract:The increased need for portable efficient power has led to the use of the fuel cell as a means of delivering that power. However, portable power also means the ability to utilize any available fuel as the situation would arise. A fuel reformer is needed that supplies the proper reformate to the… more
Abstract:There is a growing demand for power electronics that can operate under the high temperature and high power conditions that will be encountered in Hybrid Electric Vehicles (HEVs). As the coolant temperature used to dissipate heat from electronics increases, the operation of power semiconductor… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project is focused on the development of a novel, low-cost cold plate for power module thermal management. This cold plate is enabled by a unique integrated package and heat sink assembly technology. The target application for the integrated… more
Abstract:Aerodyne Research, Inc. and the University of Massachusetts at Amherst will collaborate to develop laser desorption ionization (LDI) mass spectrometric analysis of organic analytes of interest in planetary exploration, based on microchip laser illumination. The key advantage of microchip lasers in… more
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