Abstract:Our objective is to increase the sensitivity of in situ PCR , by improving methods of specimenpreparation. We have devised a LYOPHILM technology, which comprises lyophilization of specimen onspecialized microporous nitrocellulose films, to allow reactants to thoroughly penetrate specimen tomaximize… more
Abstract:ALTHOUGH SEVERAL OTC OVULATION TESTS EXIST, NON ARE SUITABLE FOR CONTRACEPTION APPLICATIONS BECAUSE THEY DETECT LUTEINIZING HORMONE (LH) WHICH EXHIBITS A PEAK PRECEDING OVULATION BY ONLY 16-36 HOURS. THIS RESEARCH WILL DEVELOP A FERTILE PERIOD PREDICTION SYSTEM BASED UPON THE PRESENCE OF AN INCREASE… more
Abstract:Although it is well established that many medical conditions occurring in postmenopausal womenare related to changes that have occurred in levels of reproductive hormones, especially estrogen, thedetails of the relationships between the levels of these hormones in symptomatic as compared… more
Abstract:Fast framing digital cameras which can acquire high spatialresolution transient wind tunnel flow-visualization imagery inboundary layers do not yet exist. To address this need,Innovation Associates proposes to develop a unique High-speedOptically Bu
Abstract:THE POTENTIAL TO ACHIEVE HIGH INSULATING VALUE BY THE USE OF EVACUATED GLASS MICROSPHERES HAS BEEN KNOWN FOR SOME TIME. THE PURPOSE OF THE RESEARCH IS TO SOLVE THE PRINCIPAL OBSTACLE TO THEIR USE, WHICH HAS BEEN THE DEVELOPMENT OF A COMMERCIALLY VIABLE TECHNIQUE TO PRODUCE EVACUATED MICROSPHERES. … more
Abstract:Significant improvements must be made in the ability of the health care system to deliver cost effective health care services. A recent Institute of Medicine study identified the development of computer-based patient record systems as being the essential technology which must be developed for… more
Abstract:SUPERSATURATION IS THE DRIVING FORCE FOR CRYSTALLIZATION FROM SOLUTION. CURRENTLY, THERE ARE NO METHODS AVAILABLE FOR MEASUREMENT OF SUPERSATURATION BASED ON CHANGES IN CHEMICAL POTENTIAL. RATHER, ALL CURRENT TECHNIQUES RELY ON MASS CONCENTRATION MEASUREMENT WHICH LACK THE SENSITIVITY FOR PROCESS… more
Abstract:An automatic control system for extracorporeal gas exchange support is presented. A microcomputer-based data acquisition, analysis, and feedback control system will be developed to control extracorporeal oxygen delivery (by adjusting extracorporeal blood flow) and carbon dioxide removal (by… more
Abstract:MECHANICAL SYSTEM SIMULATION (MSS) IS THE TECHNOLOGY USED TO ANALYZE SYSTEMS UNDERGOING LARGE OVERALL MOTION, SUCH AS AN AUTOMOBILE GOING OVER A POTHOLE OR A SPACE SHUTTLE PERFORMING SATELLITE RETRIEVAL. MSS FORMULATIONS LEAD TO A COUPLED SET OF DIFFERENTIAL AND ALGEBRAIC EQUATIONS CALLED INDEX-3… more
Abstract:This research addresses critical needs in the areas of electronic control and monitoring of internal combustion engines that require low-cost, durable, accurate, high-temperature viable, and small-size fiber optic pressure sensors for real-time in-cylinder combustion pressure measurement. By… more
Abstract:It is proposed to demonstrate the performance characteristics of a high energy density rechargeable battery based on the silver metal hydride system with an energy density of 80 Wh/Kg and over 200 Wh/l. These values are almost three times that of Pb/Acid and more than 2 times that of Ni/Cd. Ovonic… more
Abstract:Linoleic acid, the predominant polyunsaturated fatty acid (PUFA) in the human diet, can bemetabolized by cyclooxgenase, lipoxygenase and P450 enzymes. The monohydroxy derivatives oflinoleic acid, 9(S)-HODE and 13 (S)-HODE, are the most widely distributed of the known linoleic acidmetabolites. These… more
Abstract:The development of cancer is a complex process that appears to involve multiple mechanisms.Recent studies indicate that the Her-2/neu (ERBB2) gene may be important in the transformation ofnormal breast epithelial cells to a cancerous phenotype. In reality, more than one-half of breast cancersare… more
Abstract:A novel class of postaglandin F2-like compounds formed in vitro or in vivo by a free-radical catalyzed noncyclocxygenase mechanism have recently been discovered. For normal humans. Levels of these compounds (called F2-isoprostanes) range from 5-50 pg/ml plasma and 500-3000 pg/ml urinary creatinine,… more
Abstract:We will develop and market a comprehensive collection of antibodies specific for enzymes that play a significant role in drug metabolism . Availability of specific antibodies will greatly facilitate studies of polymorphisms, species and tissue distribution of drug metabolizing enzymes, and the role… more
Abstract:We are proposing a fundamental leap forwards in both technique and performance of measurement techniques for characterizing ultrahigh-speed electronic signals. We will design and build a laser-based oscilloscope for characterizing electrical signals in the picosecond time regime. The oscilloscope… more
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