Abstract:DESCRIPTION: A novel, next-generation percutaneous access device (PAD) focused on pre-emptively reducing catheter related exit site infection will be developed for the delivery of chronic, life-sustaining therapies requiring long- term access through theskin. ViaDerm II uses vacuum assist to… more
Abstract:DESCRIPTION (provided by applicant): Tetra Discovery Partners proposes to develop a new treatment for major depressive disorder based on inhibition of phosphodiesterase 4B (PDE4B). Uniquely, the Tetra drug will address inflammation as a contributor to depression. This is a new mechanism of action… more
Abstract:DESCRIPTION (provided by applicant): Understanding the brain remains a great challenge both to professional neuroscientists and the general public alike. The nervous system is extremely complex, which is why neural diseases are notoriously widespread and difficult to treat. There are two main ways… more
Abstract:DESCRIPTION (provided by applicant): This proposal describes a novel, low-cost, high-performance compact carotid ultrasound imaging system to meet the clinical point-of-care needs for stenosis assessment based upon consensus practice criteria guidelines. At the same time, this system will meet the… more
Abstract:DESCRIPTION (provided by applicant): According to UnitedHealth14 by 2020 half of all Americans would have either diabetes or pre-diabetes with an annual cost of 500 billion - mainly attributed to diabetes related complications. Diabetes is a growing epidemic yet treatment goals are seldom achieved,… more
Abstract:ABSTRACT: Ultra-high performance concrete (UHPC) materials with outstanding material properties offer significant promise to transform infrastructure design and service life. Evolution of UHPC into a mainstream construction material would benefit from the resolution of issues relevant to the… more
Abstract:Dornerworks is seeking to develop as part of this SBIR project the QuickSAT-ARLX Space Hypervisor, a space qualified hypervisor that will support the virtualization of satellite payloads, systems and software modules on a full range of satellites including CubeSATs and MicroSATs to large satellites… more
Abstract:Fabricate injectors per design developed during Phase I. Test injectors on performance bench as well as live rotary engine. Several different combinations of spray patterns will be evaluated during engine testing to optimize the combustion process.
Abstract:Global food production from plants is at risk from insect pests. To protect their crops farmers spend a great deal of money on insecticides. For example, US farmers spent $1.2 billion in 2009 on insecticides for crop protection, which resulted in $22.9 billion of additional income due to crops saved… more
Abstract:Alternative energy sources, such as wind and solar are inherently variable. Steady power to the grid can be achieved by the use of redox flow batteries to store and release power. Redox flow batteries are batteries that use a solution of redox active material that can flow past the electrodes,… more
Abstract:PowerTHRU Corporation proposes to meet or exceed the requirements of this STTR by utilizing its extensive experience in carbon fiber based high speed flywheel systems, to design and build a 100K RPM flywheel system. Unlike steel flywheel technologies that are limited by the speed in which they can… more
Abstract:DESCRIPTION (provided by applicant): There has been a huge increase in demand for comprehensive quantitative analysis of neurovascular imaging data produced in the clinical setting for diseases such as multiple sclerosis, traumatic brain injury, stroke anddementia. Our objective in this project is… more
Abstract:O-GlcNAcylation of proteins plays a critical role in cell cycle regulation, apoptosis and signal transduction. Modification of O-GlcNAcylation of proteins by O-GlcNAc transferase is reversible by the activity of O-GlcNAcase. Addition and removal of O-GlcNAc moiety to serine or threonine regulate the… more
Abstract:This Small Business Innovation Research (SBIR) Phase II project enables an innovative high-productivity approach to manufacturing hard and brittle materials like ceramics, semiconductors, and glass. The objective of this proposal is to build on the successful Phase I feasibility study to demonstrate… more
Abstract:This Small Business Innovation Research (SBIR) Phase II project addresses the challenge of automating and scaling formal equivalence verification between architectural SystemC models and RTL Verilog models for microprocessors and ASIC microcontrollers. The complexity of industrial processors,… more
Abstract:nanoRETE is a developing a nanoparticle-based biosensor technology platform that has the ability for real-time detection of pathogens. Tuberculosis (TB) is a disease caused by Mycobacterium tuberculosis (Mtb) that primarily affects the lungs. In Phase I research, nanoRETE demonstrated… more
Abstract:ABSTRACT: This project has been investigating the feasibility of converting carbon dioxide (CO2) and water into renewable liquid hydrocarbon fuel using solar energy and the same thermodynamic principles that enable biological photosynthesis; however, existing industrial technologies and processes… more
Abstract:This project will develop a low-cost Li-ion battery (LIB) anode material to enable electric and hybrid electric vehicles (EVs). XG Sciences (XGS) will develop an xGnP graphene nanoplatelet-based silicon (Si) nanocomposite LIB anode material to demonstrate the feasibility of 200 Wh/kg, 600 mAh/g and… more
Abstract:ABSTRACT: In this proposal we describe a highly flexible, ultra low-lower power GNSS receiver. By building the receiver from the ground up with flexibility and ultra-low voltage in mind, we are able to achieve a 5-20x improvement in energy-efficiency while providing support for a wide variety of… more
Abstract:ABSTRACT: Wide field of view (WFOV) video capability on unmanned aerial systems (UAS) has outpaced data transmission capability. Identifying regions of interest (often performed though object recognition) enables selective video compression and maximizes the useful content in data transmission.… more
Abstract:ABSTRACT: BTE proposes a multi-component architecture composed of structural composites and thin layers of optimal shielding materials. The structure will provide a 65 to 75% weight reduction over an aluminum or steel enclosure while providing the same structural rigidity and comparable EMI/EMP… more
Abstract:At the heart of the US armed services'effectiveness is their extensive background training. US soldiers, airmen, and others are put through exhaustive training, and their warfighting effectiveness is directly related to the quality of the training received. Part of this training includes live… more
Abstract:The goal of this program is to demonstrate the use of UAM to additively build reinforcement structures to reinforce cut outs in larger aluminum structural components. The team will work with NASA to scope a 'generic' opening in an aerospace aluminum structure. UAM will be used to perform… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project aims to establish the feasibility of a novel minimally invasive surgery (MIS) technology platform that provides enhanced dexterity, intuitive control, and natural force feedback via a low-cost mechanical design. MIS is performed through… more
Abstract:DESCRIPTION (provided by applicant): Mammography is the current cost-effective gold standard for breast cancer screening. However, its usefulness has recently become a subject of considerable debate. The limitations of mammography are most evident in the population of women who have dense breast… more
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