Abstract:DESCRIPTION: Synthetic Biology is full of promises ranging from discovery and production of new drugs, targeted therapies modifying organisms such as yeast or E. coli or creating totally new ones, higher crop yields, CO2 sequestration to bio-energy projects. However, these goals have been difficult… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project fills a key technological gap in development of biological and chemical sensor development. There is an unmet need for tests that easily detect molecular, cellular, or clinical responses that indicate disease onset or predict which… more
Abstract:This Small Business Technology Transfer (STTR) Phase I project focuses on the growth of high quality Boron Nitride Nanotubes (BNNTs). BNNTs have both high thermal conductance that is an order of magnitude higher than aluminum, and also have an electronic bandgap of about 6 eV that makes them an… more
Abstract:The USMC has an immediate need for a framework and infrastructure with which state-of-the-art AI technologies can be integrated to replace simplistic CGF behaviors in virtual simulation platforms such as VBS2. SoarTech, along with our partner Aptima, proposes to apply our vast expertise in the… more
Abstract:Improving situational awareness and accuracy of decisions in complex missions relying on streaming open-source data requires scalable information extraction and fusion in collaboration between Man and Machine reasoning. SoarTech, with its proven track-record of basic and applied research and… more
Abstract:Current Mine Countermeasure (MCM) operations attempt to balance risk and time via processes that are staff and time intensive. The range of experience in the MCM staff further complicates these processes. Existing tools such as MEDAL provide some support to address these issues, but those tools lack… more
Abstract:DESCRIPTION (provided by applicant): Although oxaliplatin is a third-generation platinum drug, it has become the most prescribed amongst all platinum drugs overtaking its predecessors, cisplatin and carboplatin. To date, oxaliplatin has become an integralpart of various chemotherapy protocols,… more
Abstract:This Small Business Innovation Research Phase I project aims to establish the feasibility of a novel moving magnet actuator (MMA) concept that holds potential to simultaneously provide up to 10 millimeter stroke, nanometric motion quality, and high scanning speeds in flexure-based nanopositioning… more
Abstract:This Small Business Innovation Research Phase 1 project will develop a spectroscopic sensor that detects and categorizes defects, predicts the composition and phase transformation, and monitors the manufacturing quality in real time for additive manufacturing industry. Current sensors for quality… more
Abstract:DESCRIPTION: Myotonic dystrophy 1 (DM1) is the leading form of adult muscular dystrophy resulting in progressive neuromuscular effects. The disease affects 1 in 6000 people. Nymirum is interested in identifying a small molecule that can be used to slow oreliminate the progression of DM1. The cause… more
Abstract:This SBIR Phase I project will deliver a breakthrough in particle-detection sensors, by integrating an amplifying junction as part of the detector topology. Focusing on energetic particle detection in the heliosphere, the resulting leap in the resolution with which the deposited charge is measured… more
Abstract:State of the art modern gasoline drivetrains have seen improvements in fuel economy thru common methods that include increased static compression ratios, Direct injection, reduced pumping work thru variable cam timing, improved Knock Sensing approaches, engine downsizing, variable displacement,… more
Abstract:To achieve high-level strategic goals, DoD elements are investigating the potential of adding autonomy to unmanned assets. An autonomous system must be able to amend its"pre-loaded"plan by rapidly assessing the current situation, examining a number of possible outcomes, initiating a course… more
Abstract:The Direct Insertion Ground Loop Heat Exchanger being developed by Promethient LLC responds to Topic 3, Subtopic d and addresses the issue GSHP ground loop cost reduction. The Principal Investigator for this program is Charles Cauchy.
The cost of installing a ground loop for Ground Source Heat Pump… more
Abstract:DESCRIPTION (provided by applicant): We propose a novel and competitive urinary tract silicone Foley catheter made from a proprietary polymeric formulation to effectively reduce catheter-associated urinary tract infections (CAUTI) via nitric oxide (NO) release. Preliminary studies show that the… more
Abstract:DESCRIPTION (provided by applicant): We propose a novel and price competitive Tunneled Dialysis Catheter (TDC) made from a proprietary polymeric formulation to effectively reduce TDC dysfunction via long-term nitric oxide (NO) release, particularly duringthe period of AVF maturation in incident… more
Abstract:Paradigm Research and Engineering proposes to develop a stand-alone blast detection and seat safety deployment system. Proposed sensor system has a Blast Detection Sensor, Energy Storage Module and Electronics Module. It has its own energy harvesting device.
Abstract:ABSTRACT: The feasibility of developing a prototype traveling-wave scanning system based on non-metallic, broadband, optical-fiber-coupled microwave-field sensors that can be used for the test and evaluation of coatings applied to the surface of aircraft without damaging the coating layers is… more
Abstract:ABSTRACT: Sensor saturation and the resultant loss of information is a problem that plagues both infrared and electro-optical sensors. Saturation often leads to blooming or dilation of the saturated region, destroying data in surrounding regions. A means for enhancing imagery through post… more
Abstract:Glycerol, also called glycerin(e), is a byproduct or contaminant of biofuel production. Glycerol must be removed from biofuels before they can be burned in order to avoid damage to combustion engines. The standard for biodiesel is less than 0.02% by weight (ASTM D6751; ASTM International sets… more
Abstract:DESCRIPTION (provided by applicant): Over 3 million emergency intubations are performed in the US every year and failure rates can be as high as 50% (3-5). Success is highly dependent on how frequently the responder performs this life-saving procedure on humans (6). Brio Device, LLC, an airway… more
Abstract:The arresting gear system on an aircraft carrier utilizes slippers and bearing materials between moving components. Presently, these bearing materials are a phenolic composite reinforced with a cotton textile and friction modified with graphite. The purpose of this proposal is to find a replacement… more
Abstract:DESCRIPTION (provided by applicant): This project will determine the efficacy of tetrathiomolybdate (TM), a potent copper- reducing compound to effectively inhibit angiogenesis and disrupt fatal micro-metastatic progression to vital organs common in humancancers. To evaluate TM's capacity in… more
Abstract:DESCRIPTION (provided by applicant): Prasan Pharmaceutical Consultants, LLC in a licensing agreement with the University of Michigan aims to advance and commercialize proprietary MRTF/SRF-transcription inhibitors for treatment of Idiopathic Pulmonary Fibrosis (IPF). IPF affects a person's… more
Abstract:Project Summary Incubators have been in use since the 19th century and have significantly improved survival for premature infants. However, incubator lighting systems still can still be improved. Proposed is a project to develop and test the feasibility and acceptability of a solid state lighting… more
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