Abstract:DESCRIPTION: Synthetic Biology is full of promises ranging from discovery and production of new drugs, targeted therapies modifying organisms such as yeast or E. coli or creating totally new ones, higher crop yields, CO2 sequestration to bio-energy projects. However, these goals have been difficult… more
Abstract:As recognized by the National Nanotechnology Initiative and the Department of Energy, Scanning Probe Microscopes are vital to the advancement of nanoscience and nanotechnology. Although there has been a steady improvement in the capabilities of commercial Scanning Probe Microscopes, instruments… more
Abstract:ABSTRACT: This STTR proposal is the natural consequence of our collaboration that makes use of the established know-how under the MURI program, the established track record of RHK in commercialization of critical hardware, software and electronic controllers to implement scanning probe microscopy… more
Abstract:The objective of this proposal is to establish the feasibility of developing an integrated decision support framework that transforms the current time-consuming and reactive (post completion of final design) sustainability assessment into a proactive CAE approach that enables the ability to revise… more
Abstract:Our vision is that of an integrated decision support solution that transforms the current time-consuming and reactive (post-design) sustainability assessment of a product into a proactive approach available in the early design phases. This solution called Sustainability Integrated into Early Design… more
Abstract:The objective of this proposal is to demonstrate the feasibility of a fully packaged microelectromechanical (MEMS) gyroscope with a 7 milliarcsecond pointing accuracyÂ?sufficient for space and terrestrial telescope pointing applications. This new environmental resistant packaged (ERP) resonant… more
Abstract:The objective of this proposal is to demonstrate the feasibility of a vibration suppression technology tailored for crystal oscillator applications called the integrated vibration isolator for Quartz (IVIQ). Vibration is an important factor for Quartz timing applications since vibration causes… more
Abstract:An integrated, in-situ, real-time, optical metrology system will be developed to measure temperature, film stress and reflectivity during CdTe and HgCdTe-based deposition applications. Temperature measurement will be performed using band-edge thermometry and blackbody radiation analysis to provide a… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project will develop a transformative green building technology that overcomes several limitations endemic to building automation systems in use today. Mainly, (a) the high cost of tethered sensor deployment, (b) the dependence on building… more
Abstract:This Small Business Innovation Research (SBIR) Phase II project aims to develop next-generation supercritical CO2 metalworking fluid (MWF) technology for highly demanding metal forming applications. The approach is to deliver specialized environmentally-friendly lubricants with supercritical CO2,… more
Abstract:Non-technical Summary: The profitability of small and mid-sized dairy farms is strongly affected by increases in feed costs and energy costs. Unfortunately, farm operators have limited control of these factors, especially in the long term. New technology is needed to allow farmers to manage energy… more
Abstract:This Small Business Innovation Research (SBIR) Phase II project proposes a potentially viable solution for many financially stressed biodiesel producers. Industry estimates that 75% of the installed base of 173 U.S. producers is currently idle. In order become economically viable, they must be able… more
Abstract:DESCRIPTION (provided by applicant): Mitral valve regurgitation is a serious condition related to heart disease. The most common and effective surgical method for treating this disease is with the use of an annuloplasty ring, which reduces the size of a dilated mitral valve to restore normal… more
Abstract:DESCRIPTION (provided by applicant): Short bowel syndrome (SBS) represents a large loss of intestinal length, compromising the absorption of nutrients and fluids to sustain life. Although patients may be maintained on parenteral (intravenous) nutrition, the morbidity can be devastating and… more
Abstract:DESCRIPTION (provided by applicant): Extracorporeal support (ECPR) improves survival in resuscitation from cardiac arrest from 5% to 30%. Extracorporeal support facilitates the salvage of donor organs after cardiac death (DCD). The Institute of Medicine report states that innovative methods to… more
Abstract:DESCRIPTION (provided by applicant): Heart valve regurgitation is a serious condition related to heart disease. The most common and effective surgical method for treating this disease is with the use of an annuloplasty ring, which reduces the size of a dilated valve annulus to restore normal… more
Abstract:DESCRIPTION (provided by applicant): Cardiogenic shock can occur after open heart surgery or in association with myocardial infarctions, and carries a high mortality. Initiation of mechanical circulatory support can restore blood flow to vital organs and potentially save lives. In this proposal, we… more
Abstract:Nutrient management is a touchy subject: there has to be a balance between regulatory concerns and adequate crop nutrition. Phosphate is an essential nutrient for plant productivity but also a major pollutant when applied in excess. On-the-spot testing for phosphate as orthophosphate (available,… more
Abstract:Electric propulsion (EP) thrusters have the potential to enhance or enable Discovery-class missions. However, a significant challenge in scaling micro (<100 W) EP devices up as well as scaling macro (> 1 kW) EP devices down is the lack of a compatible neutralizer technology in the meso scale… more
Abstract:ABSTRACT: Aerophysics has developed the Local Space Imaging System (LSIS) to provide proximity detection for spacecraft. The LSIS sensor is a small, bolt-on unit that meets many of the requirements for this solicitation: the LSIS is small, low-power, semi-autonomous, and two LSIS units could cover… more
Abstract:DESCRIPTION (provided by applicant): Cisplatin is a widely used cytotoxic agent with therapeutic activity against various tumors, but also with substantial side effects, including nephrotoxicity, hepatotoxicity and myelosuppression. Therefore, a chemoprotective agent which reduces the side effects… more
Abstract:Radiotherapy can potentially inflict serious damage on healthy normal organs. For example, pneumonitis and fibrosis are two well-recognized adverse effects from lung cancer radiotherapy: Currently, amifostine (Ethyol) is the only approved radioprotector indicated to reduce xerostomia associated with… more
Abstract:DESCRIPTION (provided by applicant): The continuing increase in the number of surgery, transplantation, cancer and other immunocompromized patients, that need treatment for fungal infections, together with the fact that only one new class of antifungal therapeutics has been introduced to the market… more
Abstract:Baker Engineering Inc. (BEI) proposes the use of a new heavy fuel Micro Injection System, paired with the R351 Rotary Engine, to exceed the specifications of this SBIR solicitation. BEI is uniquely qualified for this program as the company is currently developing a heavy fuel Micro Injection System… more
Abstract:The technical goal of this proposal is to design and develop a comprehensive USPL architecture that automatically monitors and corrects the temporal, spatial, and spectral characteristics of the output pulses thereby eliminating the need for an expert laser operator. USPL computer control has been… more
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