Abstract:DESCRIPTION (provided by applicant): This project will establish proof-of-concept for a powerful and versatile implementation of live-cell assays in a true high-throughput screening (HTS) format for small-molecule drug discovery. The technological basis isfluorescence lifetime (FLT) readout of FRET… more
Abstract:DESCRIPTION (provided by applicant): The ultimate goal of this project is to develop a safe and effective topical vaccine against the dengue virus (DENV). DENV causes an estimated 30 to 50 million cases of debilitating fever leading to over 20,000 deaths worldwide every year. DNA-based vaccines have… more
Abstract:The design, fabrication, characterization, and preclinical evaluation of novel nanoparticle-based drug formulations capable of delivering candidate RNAi therapeutics for the treatment of cancer. PUBLIC HEALTH RELEVANCE
Abstract:DESCRIPTION (provided by applicant): Alzheimer's disease and related dementias (ADRD) are an urgent healthcare challenge facing 21st Century America. In the U.S. in 2011, one person received an ADRD diagnosis every 68 seconds; by 2050, that number will beone every 33 seconds (Alzheimer's… more
Abstract:DESCRIPTION (provided by applicant): As the US population ages, Alzheimer's disease and related disorders (ADRD) will present an emotional and financial burden to an increasing number of families and the U.S. healthcare system. More than 75% of the care for persons with ADRD is provided by… more
Abstract:ABSTRACT: A better understanding of the thermo-mechanical response, characteristics and properties of materials can lead to improved device performance as well as facilitate the design of new devices and materials for various applications. Although there has been significant progress in the… more
Abstract:DESCRIPTION (provided by applicant): Eden Medical proposes to develop a Self-Sealing Therapy Ostomy Pouch (S2TOP) to stop leakage that leads to skin breakdown and trauma for ostomy care patients. The S2TOP will detect leakage, inform the patient, and prevent leakage occurrence providing better… more
Abstract:Northern Technologies International Corporation (NTIC), MN, in collaboration with Michigan State University (MSU), MI, pans to formulate and engineer chemically modified, marine biodegradable, biofiber-based, non-plastic waste bags that are water resistant, readily treatable with other organic… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project is designed to offer two uniquely tailored thermoresponsive surfaces for the attachment and release of weakly and strongly adherent cells. The commercially available surfaces are highly crosslinked hydrogels that do not work well with… more
Abstract:The Department of Defense is continually looking for opportunities to reduce the weight of fixed-wing aviation assets. Reduced weight translates to a number of significant economic and operational benefits. One area of significant opportunity for increased weight savings is wiring, which is based on… more
Abstract:In atmospheric aerosol research, size-distributed aerosol samples are often collected with airborne instrumentation, but are not analyzed in any manner until after they are brought to a laboratory on the ground. The information thus obtained is averaged for all the locations covered during the… more
Abstract:DESCRIPTION (provided by applicant): This project will provide a significantly improved method for intra-pulmonary drug delivery in pediatric patients who are intubated or have a tracheostomy. Currently available aerosolizing devices are limited in that only certain agents and only a small fraction… more
Abstract:In ballistic missile defense (BMD), sensor placement and sensor-to-target assignment are daunting tasks; even one missed threat has devastating consequences. The Missile Defense Agency (MDA) seeks innovative algorithms for sensor coordination that recommend placement and response options in… more
Abstract:Army small unit leaders face complex tradeoffs when selecting equipment and routes for a mission. Mnemonics such METT-TC and OAKOC summarize many of the factors that soldiers consider, but quickly and comprehensively analyzing these elements is challenging. Primordial"s flagship product,… more
Abstract:The proposed technology: GROK (Generating Reports On Knowledge) combines existing open source research tools to automatically generate reports from a dynamically changing set of documents. GROK presents the generated reports with a novel, uncluttered interface designed to save the analyst time in… more
Abstract:ABSTRACT: Military missions increasingly rely on satellites for surveillance, communication, and navigation. While performing these mission-critical tasks, satellites must respond quickly to new enemy threats and changing mission objectives. Under prior AFRL SBIR awards, SIFT and TRACLabs have… more
Abstract:ANSIBLE (A Network of Social Interactions for Bilateral Life Enhancement) can be used pre, during, and post flight to connect the flight crew with their family, friends, and the ground crew to provide a sense of social consistency and permanence. ANSIBLE is a multi-modal toolset that 1) adapts,… more
Abstract:ABSTRACT: SIFT will dramatically improve the Air Force's ability to train using synthetic teammates by leveraging prior synthetic teammate research to develop a generalized and reusable natural language interaction (NLI) development toolkit for constructive agents. We will simplify the… more
Abstract:Complex systems are inherently difficult to analyze because they include multiple sub-systems that interact in stochastic and context-dependent ways. A particular challenge in designing such systems is to foresee the possible emergent interactions between the sub-systems. System repurposing makes… more
Abstract:The proposed STRIDER (Semantic Targeting of Relevant Individuals, Dispositions, Events, and Relations) technology combines an open source semantic parser with task-specific knowledge structures and diagram-based user interfaces to automatically extract, display, and record mission-relevant… more
Abstract:The main challenges of treating PTSD include getting patients into treatment, keeping them engaged, and motivating them to complete out-of-session take-home work. SAGA (Sequential Art via Game Assistance) addresses these challenges by providing PTSD patients an engaging and educational game… more
Abstract:The negative-electron-affinity (NEA) photocathodes which produce polarized electrons are a vital component of electron accelerators such as that at the Stanford Linear Accelerator Center (SLAC) and DoE Jefferson Lab. Future systems, such as the International Linear Collider (ILC), will require a… more
Abstract:The negative-electron-affinity (NEA) photocathodes which produce polarized electrons are a vital component of electron accelerators such as that at DoE Jefferson Lab and the Stanford Linear Accelerator Center (SLAC). Future systems, such as the International Linear Collider (ILC), will require a… more
Abstract:SVT Associates proposes an novel type II superlattice structure to extend the cutoff wavelength and CBIRD SL photo diode structure with unipolar barriers to suppress dark current of SL detectors grown on GaSb substrate. This InAs/GaSb superlattice material system is capable of infrared detection in… more
Abstract:DESCRIPTION (provided by applicant): The significance of the proposed research is based on the growing demand for healthcare resources to treat and manage prostatic disease, particularly benign prostatic hyperplasia (BPH) and cancer. Both the incidence andcost of treatment for BPH, and its… more
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