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Displaying 1726 – 1750 of 2021 Awards
Company: Apa Optics, Inc. Agency/Program/Year/Phase: DOD / SBIR / 1991 / 1
Abstract: N/A
Company: Biomedical Frontiers, Inc. Agency/Program/Year/Phase: HHS / SBIR / 1991 / 1
Abstract: N/A
Company: SURMODICS, INC. Agency/Program/Year/Phase: HHS / SBIR / 1991 / 2
Abstract: NUMEROUS ANCHORAGE-DEPENDENT CELLS SHOW IMPROVED ATTACHMENT,IMPROVED GROWTH, AND REDUCED SERUM REQUIREMENTS WHEN CULTURED ON SURFACES COATED WITH EXTRACELLULAR MATRIX COMPONENTS (ECM'S). THE MAJOR ACTIVE PROTEINS IN ECM'S ARE FIBRONECTIN, LAMININ, AND TYPE IV COLLAGEN. MOST OF THE CELL ADHESION… more
Company: SURMODICS, INC. Agency/Program/Year/Phase: HHS / SBIR / 1991 / 2
Abstract: PROSTHETIC DEVICES ARE ROUTINELY IMPLANTED IN PATIENTS; HOWEVER, AN ESTIMATED 850,000 CASES OF IMPLANTATION INFECTIONS OCCUR IN THE UNITED STATES EACH YEAR. THE INFECTIOUS ORGANISMS ARE MOST LIKELY TO BE INTRODUCED AT THETIME OF SURGERY. CURRENTLY, INFECTIONS RESULTING FROM IMPLANTATION ARE TREATED… more
Company: SURMODICS, INC. Agency/Program/Year/Phase: HHS / SBIR / 1991 / 2
Abstract: THE USE OF TOBACCO PRODUCTS WITH ALL ITS DELETERIOUS EFFECTSUPON THE GENERAL HEALTH OF OUR POPULACE WAS AND STILL IS A MAJOR HEALTH PROBLEM. ALTHOUGH THE NUMBER OF SMOKERS HAS DECREASED OVER THE LAST DECADE, SMOKERS ARE SMOKING MORE CIGARETTES AND ADOLESCENTS ARE USING NOT ONLY CIGARETTES BUTALSO… more
Company: SURMODICS, INC. Agency/Program/Year/Phase: HHS / SBIR / 1991 / 2
Abstract: THE IMMOBILIZATION OF BIOLOGICALLY ACTIVE MOLECULES ON SUPPORT MATRICES HAS MANY APPLICATIONS IN BIOTECHNOLOGY. PASSIVE ADSORPTION OF BIOMOLECULES (BOTH HYDROPHOBIC AND IONIC) TO POLYMERIC MATRICES IS THE LEAST COMPLICATED METHOD OF IMMOBILIZATION; HOWEVER, MANY BIOCHEMICALS DO NOT ADSORB WELL TO… more
Company: SURMODICS, INC. Agency/Program/Year/Phase: HHS / SBIR / 1991 / 2
Abstract: ALL POLYMERS USED FOR IMPLANT DEVICES THAT CONTACT BLOOD ARETHROMBOGENIC, AND NO CURRENT SURFACE TREATMENTS ARE SATISFACTORY. THIS PROJECT PROPOSES TO USE A RECENTLY CHARACTERIZED PEPTIDE, HIRUDIN, TO DEVELOP A SUPERIOR ANTITHROMBIC SURFACE TREATMENT. HIRUDIN IS ONE OF THE MOST POTENT ANTITHROMBIC… more
Company: SURMODICS, INC. Agency/Program/Year/Phase: DOD / SBIR / 1991 / 2
Abstract: THE ENZYME-LINKED IMMUNOSORBENT ASSARY (ELISA) IS A MAJOR TOOL FOR DETECTING INFECTIOUS AGENTS, PROTEINS, AND DRUGS IN BIOLOGICAL FLUIDS, OR CONTAMINANTS IN ENVIRONMENTAL SAMPLES. THE MAJORITY OF ELISA'S ARE DESIGNED TO DETECT A SINGLE ANALYTE. WE PROPOSE HERE TO DEVELOP A THREE-ENZYME ELISA SYSTEM… more
Company: SURMODICS, INC. Agency/Program/Year/Phase: NSF / SBIR / 1991 / 1
Abstract: THE CONCEPT OF PHOTOAFFINITY IMMOBILIZATION OF SPECIFIC BINDING PROTEINS HAS BEEN PATENTED AND REDUCED TO PRACTICE WITH ANTIBODY ON GLASS BY THIS COMPANY. THE DEVELOPMENT OF ADDITIONAL REAGENTS AND REACTION PROCEDURES IS PROPOSED FOR THE AFFINITY COUPLING (COVALENT) OF RECEPTOR MOLECULES (ESPECIALLY… more
Company: SURMODICS, INC. Agency/Program/Year/Phase: DOD / SBIR / 1991 / 1
Abstract: A PROJECT IS PROPOSED TO DEVELOP A BIOSENSOR FOR MEASURING PATHOGENIC MICROORGANISMS IN WATER BY MEASURING CHANGES IN CONDUCTANCE ACROSS MICROPOROUS, POLYCARBONATE MEMBRANE COATE WITH SPECIFIC ANTIBODIES. THE MEMBRANES WILL BE COATED WITH HYDROPHILIC POLYMERS USING PHOTOCHEMICAL COUPLING. ANTIBODIES… more
Company: SURMODICS, INC. Agency/Program/Year/Phase: HHS / SBIR / 1991 / 1
Abstract: CURRENTLY, ABOUT 10% OF THE HOSPITAL PATIENTS IN THE UNITED STATES RECEIVE IN-DWELLING URINARY CATHETERS, AND THESE CATHETERS LEAD TO OVER 400,000 CASES PER YEAR OF CATHETER-ASSOCIATED URINARY TRACT INFECTIONS. IN ADDITION, THESE CATHETERS IRRITATE URETHRAL SURFACES, CAUSING PAIN UPON INSERTION,… more
Company: SURMODICS, INC. Agency/Program/Year/Phase: HHS / SBIR / 1991 / 1
Abstract: WE WILL DEVELOP AND DEMONSTRATE THE FEASIBILITY OF AN ENZYMEIMMUNOASSAY FORMAT CAPABLE OF SIMULTANEOUSLY DETECTING AND IDENTIFYING ANY ONE OR MORE OF MULTIPLE DRUGS IN BLOOD FROM A FINGER PRICK. THE EVENTUAL GOAL IS TO DEVELOP A SCREENINGTEST DEVICE HAVING A BUILT-IN SAMPLER WHICH WOULD ALLOW THE… more
Company: SURMODICS, INC. Agency/Program/Year/Phase: NSF / SBIR / 1991 / 1
Abstract: N/A
Company: SURMODICS, INC. Agency/Program/Year/Phase: HHS / SBIR / 1991 / 1
Abstract: N/A
Company: Biotrol Inc Agency/Program/Year/Phase: EPA / SBIR / 1991 / 1
Abstract: ADDITION OF COSOLVENTS TO WATER INCREASES THE SOLUBILITY OF HYDROPHOBIC CONTAMINANTS BY SHIFTING THE ADSORPTION EQUILIBRIUM TO FAVOR HIGHER AQUEOUS PHASE CONCENTRATIONS. INCREASING THEIR WATER SOLUBILITY MAKES CONTAMINANTS MORE ACCESSIBLE FOR BIODEGRADATION. WHILE IT IS OFTEN SPECULATEDTHAT LOW… more
Company: Brimson Laboratories Agency/Program/Year/Phase: HHS / SBIR / 1991 / 1
Abstract: IN CLOSE COLLABORATION WITH ONGOING WORK AT THE UNIVERSITY OF MINNESOTA NUTRITION COORDINATING CENTER (NCC), THE OBJECTIVE OF THIS PROJECT IS TO DESIGN (IN PHASE I) AND FULLY DEVELOP (IN PHASE II) A NEW USER INTERFACE TO NCC'S FOOD AND NUTRIENT DATABASES. THE EXISTING NCC MINNESOTA NDS SOFTWARE IS… more
Company: Cyberoptics Corp Agency/Program/Year/Phase: DOD / SBIR / 1991 / 1
Abstract: AS THE COMPLEXITY AND FUNCTIONALITY OF MICROELECTRONIC COMPONENTS INCREASED, STANDARD PACKAGING AND INTERCONNECTION TECHNOLOGIES LIMIT THE DEVELOPMENT OF ELECTRONIC SYSTEMS. TO INCREASE THE DENSITY OF ELECTRONIC COMPONENTS, NEW TECHNIQUES SUCH AS FLIP-CHIP BONDING HAVE BEEN DESIGNED TO ALLOW… more
Company: D And M Computing, Inc Agency/Program/Year/Phase: HHS / SBIR / 1991 / 1
Abstract: THE PHASE I RESEARCH WILL DEMONSTRATE THE TECHNICAL MERIT AND FEASIBILITY OF ROUTINE ANALYSIS OF RED CELL VOLUME DISTRIBUTIONS IN THE DIAGNOSTIC EVALUATION OF ANEMIA USING A DEDICATED CONTROLLER WITH A REDUCED-INSTRUCTION-SET-COMPUTER (RISC) MICROPROCESSOR. CURRENT AUTOMATED HEMATOLOGY ANALYZERS… more
Company: Empi Inc. Agency/Program/Year/Phase: HHS / SBIR / 1991 / 1
Abstract: N/A
Company: Endotronics Inc. Agency/Program/Year/Phase: HHS / SBIR / 1991 / 2
Abstract: ADOPTIVE CELLULAR IMMUNOTHERAPY (CI), SPECIFICALLY LYMPHOKINE-ACTIVATED KILLER (LAK) CELLS, HAS DEVELOPED INTO A PROMISING METHOD FOR EFFECTIVE CANCER THERAPY. UNFORTUNATELY, LAK CELL THERAPY IS LIMITED BY THE LABOR-INTENSIVE TASK OF GENERATING LARGE NUMBERS OF ACTIVATED LYMPHOCYTES. CONVENTIONAL… more
Company: Gateway Modeling, Inc. Agency/Program/Year/Phase: DOD / SBIR / 1991 / 1
Abstract: A COMBINED PROCESS AND DEVICE MODELING COMPUTER PROGRAM FOR HIGH-ELECTRON MOBILITY TRANSITOR (HEMT) MM-WAVE TECHNOLOGYWILL BE DEVELOPED. THE PROGRAM WILL ALLOW ENGINEERS TO TRY OUT DIFFERENT TYPES OF TRANSISTOR DOPING, LAYER THICKNESSES, AND FET LAYOUTS BYCOMPUTING I-V CHARACTERISTICS,… more
Company: Information Technology Design Agency/Program/Year/Phase: ED / SBIR / 1991 / 1
Abstract: LASERLAND MATH IS A SERIES OF INTERACTIVE LEARNING MODULES FOR STUDENTS IN THE PRIMARY GRADES. THE SERIES WILL PROMOTETHE DEVELOPMENT OF MATHEMATICAL SKILLS, PROBLEM-SOLVING ABILITIES AND NUMBER SENSE. PHASE I WILL RESULT IN (1) THE DEVELOPMENT OF A CONCEPTUAL FRAMEWORK FOR THE ENTIRE SERIES,(2) THE… more
Company: INNOVATIVE RESEARCH, INC. Agency/Program/Year/Phase: DOD / SBIR / 1991 / 2
Abstract: THE DEVELOPMENT OF SIMULATION MODELS OF A DISTRIBUTED SYSTEMS AND THEIR MAPPING INTO A PARALLEL SYSTEM, IS A HIGHLY COMPLEX TECHNICAL TASK BECAUSE OF THE GREAT INFLUENCE ITS VARIOUS ELEMENTS WILL HAVE ON ITS PERFORMANCE. THERE ARE MAJOR TECHNICAL ISSUES INVOLVED IN PERFORMING SUCH COMPLEX SIMULATION… more
Company: KNIGHTRONIX, INC. Agency/Program/Year/Phase: DOD / SBIR / 1991 / 1
Abstract: N/A
Displaying 1726 – 1750 of 2021 Awards
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