Abstract:DESCRIPTION (provided by applicant): Design of experiments and test of hypotheses need to be available to research teams to develop and validate taxonomic metagenomic biomarkers in gastrointestinal tract (GIT) diseases. The translational research team needs to 1) design an experiment to test a… more
Abstract:With over 80 years of combined experience in simulation and engineering, the four-member Visual Performance technical team will assess the feasibility of developing an objective and efficient measurement toolkit. The proposed design will meet, if not exceed, the minimum requirements set forth in the… more
Abstract:Project Summary / Abstract Coronary heart disease (CHD) accounts for every 1 of 6 deaths in the United States (US), with acute incidences estimated at 1.1M annually . Of these, up to 40% are classified as ST-elevation myocardial infarction (STEMI) in which a clot blocks a coronary artery, leading… more
Abstract:DESCRIPTION (provided by applicant): Acute ischemic stroke (AIS) is the result of a blood clot in a cerebral artery. It remains a leading killer and the leading cause of long-term disabilit, annually impacting over 700,000 Americans . Because brain tissue rapidly dies, time to reperfusion is… more
Abstract:Project Summary/Abstract Dysregulation of apoptosis pathways and loss of Human Beta Defensin-1 (hBD-1) are the common tactics adapted by cancer cells to circumvent the effects of chemotherapy. Consequently, high dose of chemotherapy is required to obtaina clinically relevant therapeutic index which… more
Abstract:DESCRIPTION (provided by applicant): Over 15 million women suffer from urinary tract infections (UTI) annually in the U.S. and approximately 20-40% of these patients suffer from multiple recurrences. UTI is unique in its high prevalence of chronic/recurrent infections, which has caused a tremendous… more
Abstract:In this project, researchers will evaluate the potential for utilizing biofuel co-products for high value biobased materials. The two key biobased materials that will be investigated are glycerol carbonate and sucrose esters. The goal of the project is to develop commercially viable, energy… more
Abstract:DESCRIPTION (provided by applicant): CD47 has emerged as a novel therapeutic target in hematologic cancers. Leukemias expressing the highest levels of CD47 have the worst prognosis. Increased CD47 expression is thought to protect cancer cells from phagocytic clearance by sending a don't eat me… more
Abstract:DESCRIPTION (provided by applicant): Organ transplantation is a lifesaving option for those with end stage renal disease. In spite of many improvements in organ procurement, transplant procedures and immune suppression, the damage done by ischemia-reperfusion injury (IRI) remains problematic,… more
Abstract:DESCRIPTION (provided by applicant): Bone metastasis is common in patients with advanced breast, prostate, and lung cancers as these tumors have a remarkable ability to metastasize to bone. Two-thirds of patients with metastatic bone cancer experience severe pain which is usually described as dull… more
Abstract:An oscillating heat pipe (OHP) embedded substrate made from low coefficient of thermal expansion (CTE) material(s) will be designed, simulated, optimized, fabricated, and empirically tested to demonstrate the OHP technology's ultra-high heat transfer rates under real-world microchip operating… more
Abstract:ThermAvant Technologies, LLC and University of Texas at Arlington propose to design, model, fabricate and empirically test conformal fitting cylindrical energy storage heat cooling packages. ThermAvant will optimize cylindrical battery array cooling solutions that balance size, weight, coolant flow… more
Abstract:ABSTRACT: High Energy X-ray computed tomography (CT) is used to inspect the integrity of solid rocket motors. The purpose of this proposal is to improve the detection of defects when they are obscured due to physical limitations of CT. Lickenbrock has developed an advanced variant of the… more
Abstract:Nuclear power is a key component in the strategy to meet the countrys energy goals and technologies are needed to improve the reliability of current reactors and disposing safely of nuclear wastes. Vitrification is considered the preferred process
for nuclear waste disposal and the U.S. Department… more
Abstract:This Small Business Technology Transfer (STTR) Phase I project will prove the technical and commercial feasibility of a single-use polymer microarray for electromechanical transfection of biological cells. Alternative gene transfer solutions are needed to access the potential held in… more
Abstract:DESCRIPTION (provided by applicant): The broad, long-term objective of the proposed research is to develop and market a commercial software product that can be used to facilitate the analysis of genetic changes in order to elucidate chromosomal abnormalities that underlie diseases such as autism… more
Abstract:A major component of airframe noise for commercial transport aircraft is the deployed landing gear. The noise from the gear originates due to complex, unsteady bluff body flow separation from gear components and the subsequent multiple interactions of unsteady wakes with downstream undercarriage… more
Abstract:In this program, Innovative Technology Applications Company (ITAC), LLC and collaborators propose to advance "synthetic phased array" technology to improve understanding of noise from landing gear. The technology, initially developed in a previous NASA SBIR project for trailing edge noise,… more
Abstract:ABSTRACT: Under this Small Business Technology Transfer (STTR) program, Innovative Technology Applications Company (ITAC), LLC and the University of Notre Dame (UND) are working to develop new optical instruments that will enable nonintrusive, off-body measurements of flow parameters in hypersonic… more
Abstract:The objective of the proposed research and development work is to create non-lethal munitions that generate high-power microwave (HPM) pulses to defeat the electronics used to activate Improvised Explosive Devices (IEDs) or to attack blasting caps to pre-detonate IEDs. To provide the best Phase I… more
Abstract:QM Power will design, build and test a high performance 3kW alternator using Parallel Path Magnetic Technology (PPMT) with no at risk rare earth magnet materials that is smaller, lighter and more efficient than the existing alternator that uses rare earth magnets. The Parallel Path Magnetic… more
Abstract:The main objective of this work is to develop and commercialize light-weight transparent composites with high tensile strength, toughness and impact resistance. Novel techniques will be developed for the design and manufacturing of these lightweight composite materials with improved blast resistance… more
Abstract:This Small Business Innovation Research (SBIR) Phase II project applies a novel design to pneumatic solenoid valves that allows 20-25% of compressed air to be recycled. Given compressed air is one of the most expensive forms of stored energy, this energy-efficient design provides manufacturers with… more
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