Abstract:This Small Business Innovation Research (SBIR) Phase I project aims to engineer a biocatalyst for efficient transformation of feedstocks into a linear, volatile olefin, namely propylene. Current production of propylene from fossil fuels is unsustainable from economical, environmental, and social… more
Abstract:This Small Business Innovation Research Phase I project aims to engineer novel biocatalysts for cost-effective production of malic acid from CO2. Malic acid is a key intermediate in energy metabolism of all living species. Additionally, presence of two carboxyl and one hydroxyl groups makes it an… more
Abstract:This Small Business Innovation Research Phase I project applies a novel approach to the design of pneumatic solenoid valves to significantly reduce manufacturing energy consumption. In the United States, over 70% of all manufacturing facilities employ compressed air systems with low efficiency,… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project is to develop a hidden and noninvasive assistive device that can provide in-situ sensory feedback of head movement for patients with vestibular imbalance. Loss of vestibular feedback in the sensorimotor control loop of the human body… more
Abstract:This proposal is for the development of an innovative compact and mobile laser system to safely remove coatings from composite aircraft structures. The proposed laser based system will also be capable of preparing damaged composite surface for structural bonding. The use of lasers as a surface… more
Abstract:DESCRIPTION (provided by applicant): The overall objective of this research is to test the hypothesis that monoclonal antibodies to radiation-induced tumor neoantigens cause therapeutically beneficial immune responses in cancer models. We will study the efficacy of a mouse monoclonal antibody to a… more
Abstract:The function of many cancer related proteins is modulated by modifications such as phosphorylation and glycosylation. The development of antibodies that recognize site-specific phosphorylation has vastly improved our understanding of signal transductionand cancer cell physiology and regulation.… more
Abstract:DESCRIPTION (provided by applicant): Organ transplantation is one of the great success stories of modern medicine. However, the supply of suitable organs lags far behind the need and many patients die while waitlisted for organs. While there have been manyrecent strides in organ procurement,… more
Abstract:This Small Business Innovation Research (SBIR) Phase II project proposes the development of novel enzymes (DNA polymerases) and other improvements for rapid detection of food-borne pathogens by DNA detection and amplification (PCR). PCR is a very fast and accurate method of pathogen detection,… more
Abstract:DESCRIPTION (provided by applicant): This grant will seek to develop a methodology that will allow us to test whether a promising new class of drugs for Alzheimer's disease is having the desired effect in the human brain. This methodology will allow pharmaceutical companies to make informed… more
Abstract:This Small Business Innovation Research (SBIR) by Mo-Sci Corporation in collaboration with the Indiana University School of Dentistry (IU) and the Missouri University of Science & Technology (Missouri S & T) proposes to use bioactive glass bone scaffolds for bone repair. The objective is to… more
Abstract:DESCRIPTION (provided by applicant): Improved long-term biocompatibility of coronary stents by plasma coating process Abstract Drug-eluting stents (DES) have been widely used to treat patients of cardiac disease due to their better ability to control restenosis than bare metal stents (BMS). However,… more
Abstract:ABSTRACT: Flight tests of hypersonic maneuvering vehicles are a challenging but necessary endeavor. While ground tests and numerical simulations can provide important guidance regarding vehicle performance, they are both limited in their reach. Likewise surface-based measurements during flight… more
Abstract:Use of an airborne platform for a directed energy system is currently severely limited by aero-optic aberrations arising from density variations in air flowing over the aircraft; the primary limitation is for aft pointing applications. Innovative Technology Applications Company (ITAC), in… more
Abstract:The primary goal of the Phase II program to advance plasma-enhanced aerodynamic control (PEAC) concepts, methods, and techniques to improve V-22 Osprey wing aerodynamics that directly impact efficient cruise and hover. Replacing passive vortex generators with active, dielectric barrier discharge… more
Abstract:IST-Rolla developed two nonlinear filters for spacecraft orbit determination during the Phase I contract. The theta-D filter and the cost based filter, CBF, were developed and used in various orbit determination scenarios. The scenarios were application to low Earth orbit, range only, and range and… more
Abstract:ABSTRACT: This proposal seeks to develop a novel tool wear monitoring technology using a neural network-based observer. In this methodology simple models of the wear process and another related machining process, such as force, are developed. The model development does not require lengthy analysis… more
Abstract:Glycosylation changes are a universal feature of malignant transformation and tumor progression. Changes in expression levels of certain glycoproteins and altered glycosylation patterns have been detected in most of the major human cancer types and at different stages of tumor progression. The… more
Abstract:According to the American Cancer Society, 192,370 women in the United States will be diagnosed with invasive breast cancer in 2010, leading to 40,170 deaths. Most women with breast cancer undergo surgery to remove the cancerous tissue and then receive additional treatment. Adjuvant therapy does not… more
Abstract:A Fast Impulse Solid Fuel Miniature Thruster system will be developed for a specific application beneficial to the US Army. The selection of right nanoenergetic material will be done from various fuel-oxidizer systems to obtain thrust and specific impulse as required by the application. Fine-tuning… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project will develop a Multi-Axis Repair System (MARS), which is an automated precision alignment and repair planner and driver. MARS will make repair processes much more cost-effective and robust. Insufficient automation in current repair… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project evaluates a completely new low cost/high efficiency generator system called Q-Gen? Portable for use in portable recharging devices. The Q-Gen? Portable will recharge handheld electronic devices (laptops, cell phones etc) without… more
Abstract:QM Power will build and empirically test Space and Cryogenic qualified preproduction Parallel Magnetic Circuit [PMC] 1-5 HP motor/actuators with electronic controllers. These preproduction prototypes will demonstrate lower operating power requirements for cryogenic motor/actuator components used in… more
Abstract:Refrigeration and air conditioning in buildings, industry, and transportation account for approximately 10 quads of U.S. primary energy consumption. Motors power the equipment and control the environment in advanced cooling applications and thus their energy consumption represents a significant part… more
Abstract:Today, conventional hydropower generation accounts for 75% of the United States renewable energy generation (over 270,000 GWH) despite utilizing less than 20% of the usable hydropower available for development. Recent studies indicate that advances in lower cost higher performing generator… more
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