Abstract:DESCRIPTION (provided by applicant): Improved long-term biocompatibility of coronary stents by plasma coating process Abstract Drug-eluting stents (DES) have been widely used to treat patients of cardiac disease due to their better ability to control restenosis than bare metal stents (BMS). However,… more
Abstract:ABSTRACT: Flight tests of hypersonic maneuvering vehicles are a challenging but necessary endeavor. While ground tests and numerical simulations can provide important guidance regarding vehicle performance, they are both limited in their reach. Likewise surface-based measurements during flight… more
Abstract:Use of an airborne platform for a directed energy system is currently severely limited by aero-optic aberrations arising from density variations in air flowing over the aircraft; the primary limitation is for aft pointing applications. Innovative Technology Applications Company (ITAC), in… more
Abstract:The primary goal of the Phase II program to advance plasma-enhanced aerodynamic control (PEAC) concepts, methods, and techniques to improve V-22 Osprey wing aerodynamics that directly impact efficient cruise and hover. Replacing passive vortex generators with active, dielectric barrier discharge… more
Abstract:IST-Rolla developed two nonlinear filters for spacecraft orbit determination during the Phase I contract. The theta-D filter and the cost based filter, CBF, were developed and used in various orbit determination scenarios. The scenarios were application to low Earth orbit, range only, and range and… more
Abstract:ABSTRACT: This proposal seeks to develop a novel tool wear monitoring technology using a neural network-based observer. In this methodology simple models of the wear process and another related machining process, such as force, are developed. The model development does not require lengthy analysis… more
Abstract:Glycosylation changes are a universal feature of malignant transformation and tumor progression. Changes in expression levels of certain glycoproteins and altered glycosylation patterns have been detected in most of the major human cancer types and at different stages of tumor progression. The… more
Abstract:According to the American Cancer Society, 192,370 women in the United States will be diagnosed with invasive breast cancer in 2010, leading to 40,170 deaths. Most women with breast cancer undergo surgery to remove the cancerous tissue and then receive additional treatment. Adjuvant therapy does not… more
Abstract:A Fast Impulse Solid Fuel Miniature Thruster system will be developed for a specific application beneficial to the US Army. The selection of right nanoenergetic material will be done from various fuel-oxidizer systems to obtain thrust and specific impulse as required by the application. Fine-tuning… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project will develop a Multi-Axis Repair System (MARS), which is an automated precision alignment and repair planner and driver. MARS will make repair processes much more cost-effective and robust. Insufficient automation in current repair… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project evaluates a completely new low cost/high efficiency generator system called Q-Gen? Portable for use in portable recharging devices. The Q-Gen? Portable will recharge handheld electronic devices (laptops, cell phones etc) without… more
Abstract:QM Power will build and empirically test Space and Cryogenic qualified preproduction Parallel Magnetic Circuit [PMC] 1-5 HP motor/actuators with electronic controllers. These preproduction prototypes will demonstrate lower operating power requirements for cryogenic motor/actuator components used in… more
Abstract:Refrigeration and air conditioning in buildings, industry, and transportation account for approximately 10 quads of U.S. primary energy consumption. Motors power the equipment and control the environment in advanced cooling applications and thus their energy consumption represents a significant part… more
Abstract:Today, conventional hydropower generation accounts for 75% of the United States renewable energy generation (over 270,000 GWH) despite utilizing less than 20% of the usable hydropower available for development. Recent studies indicate that advances in lower cost higher performing generator… more
Abstract:Medical robotic applications require numerous actuation devices that must be both lightweight and efficient. In the case of mobile medical robotics, Space, Weight, and Power efficiency (SWaP) are the key performance attributes for most designs. The objective of this proposal is to design and… more
Abstract:DESCRIPTION (provided by applicant): A rapid method for concentrating bacteria from real apple juice and spinach wash water into a small volume, which is easily analyzed by advanced detectors, will enable rapid detection of small numbers of bacteria and provide for improved consumer safety and… more
Abstract:Detection of bioaerosols is a cornerstone in the protection of our nation from bioterrorist events. Rapid bioaerosol detection systems
have advanced dramatically in recent years, but the lack of integratable automated sample preparation for these systems remains a
major deficiency. Three significant… more
Abstract:Shock-wave/boundary-layer interactions (SWBLI) pose challenges to aeronautical engineers because they create regions of adverse pressure gradients as a result of the discontinuous change in conditions across the shock. This shock-induced pressure gradient is a common factor for both flow separation… more
Abstract:DESCRIPTION (provided by applicant): The purpose of this SBIR project is to develop a new dual-modality inflammation imaging technology to early detect Uveitis, an ocular inflammation-related disorder. This technology, based on nanocomposites (NCs) that function as dual-modality fluorescent and… more
Abstract:DESCRIPTION (provided by applicant): Nitric oxide (NO) has been shown to have powerful, broad-spectrum antimicrobial activity as well as benefits in wound healing when properly administered [1-3]. The combination of these two attributes makes development of a non-systemic NO delivery approach… more
Abstract:DESCRIPTION (provided by applicant): Atrial fibrillation (AF) is the most prevalent clinical arrhythmia in clinical practice and a major contributor to morbidity and mortality. A recent study estimated that the number of Americans afflicted by AF will increase from the current range of 2.2 to 5.6… more
Abstract:DESCRIPTION (provided by applicant): Cells secrete hormones and neurotransmitter via exocytosis. Understanding how exocytosis is regulated and how pharmaceuticals and toxins inhibit exocytosis is of broad medical significance. The overall goal of this SBIRproject is to use microfabrication… more
Abstract:The androgen receptor (AR) remains a key therapeutic target for prostate cancer (PCa), even in castration resistant PCa (CRPC). Current therapies target AR by blocking androgen synthesis or competitive antagonism. ARTA Bioscience is developing an early lead, ABS-001, a non-competitive AR inhibitor… more
Abstract:Invention House LLC proposes to lower the initial cost of solar energy by minimizing the material used in the reflector of a concentrating trough. Placing the support structure on the front (sun) side and using a thin reflecting membrane will reduce material usage and cost by approximately 66%. The… more
Abstract:HyBeacons Probe Assays for the Detection of Ticks and Tick-Borne Pathogens Patrick Williams, Ph.D., Evogen Inc., 8301 State Line Road, Kansas City, MO 64114 The proposed development will evaluate the use of Evogen"s HyBeacons probes for rapid, multiplexed vector and pathogen detection using… more
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