Abstract:PRESENT TREATMENT OF RHEUMATOID ARTHRITIS IS PERFORMED BY SEVERAL METHODS, WHICH INCLUDE ANTI-INFLAMMATORY AGENTS, STEROIDS, IMMUNOSUPPRESSIVE AND CYTOTOXIC AGENTS, RADIATION TREATMENT BY BEAM METHOD, AND SURGERY. EACH METHOD HAS ITS DRAWBACKS. OF THESE METHODS, RADIATION BEAM TREATMENT HAS BEEN… more
Abstract:A new family of bioactive iron calcium phosphate glasses will be evaluated as thermoseeds for hyperthermia of cancers, especially bone tumors. Through appropriate heat treatment and atmosphere control, the Fe3+/Fe2+ ratio can be adjusted to achieve the desired magnetic hysteresis. The heat… more
Abstract:The objective of Phase I is to select a small number (3 - 5) of synthetic compounds with high biological activities as inhibitors of cancer cell aggregation, adhesion, detachment and spreading (motility). These compounds will be selected from a panel of 20 currently available synthetic structural… more
Abstract:A six-month effort is proposed to utilize the author's expertise in semiconductor laser diodes and fiber-optic technology to develop a design for a 50 to 100 watt fiber-coupled laser-diode source. A proprietary technique is described for achieving high power and high power density in the fiber which… more
Abstract:TELEPHONE NUMBER: (314) 429-7700 AWARDEE NUMBER: 1 R43 CA61390-01 The overall objective is to develop polysulfated carbohydrate derivatives that will inhibit the action of fibroblast growth factors (FGF). FGF's have been implicated in several human cancers both as angiogenic factors and as growth… more
Abstract:The overall objective is to develop a process to produce lactobionic acid that is free of oxidizing components. Lactobionic acid is an essential component of perfusion solutions used to preserve organs for transplantation (Sumimoto, 1990). It functions as an impermeant and calcium chelator as well… more
Abstract:RESEARCHERS ARE DESIGNING, IMPLEMENTING, AND TESTING THE FEASIBILITY OF A SOFTWARE MODULE TO TRANSLATE SPIRAL CT SCAN DATASETS OF DISCRETE OBJECTS INTO SOLID MATHEMATICAL MODELS (BOUNDARY REPRESENTATION-GEOMOD IN SDRC I-DEAS). THIS PROVES THE CONCEPT AND DEMONSTRTES THE FASIBILITY OF DIRECT INPUT… more
Abstract:There is no established non-contact method to quantify surface morphology or edema and objectively assess change resulting from facial reconstructive or cosmetic plastic surgery. We will develop and test a quantification technique based on a three dimensional, non-contact, optical range sensing… more
Abstract:We will develop a computer-based training system for fourth through sixth graders which presents factual information in an engaging and enjoyable manner. The system will incorporate advanced computing technologies, interactive multimedia, hypertext, and simulation to maximize learning in a flexible… more
Abstract:The lack of Multilevel Secure (MLS) computer systems within the Department of Defense (DOD) is recognized as a significant shortcoming. Past efforts to build secure computing environments have resulted in a multiplicity of single-level systems, operating on a system high mode, with each system… more
Abstract:A variety of mission planning scenarios rely on the mission support system to have the ability to produce simulated perspective scenes of the theater of operations of interest. These simulated scenes range from low to medium altitude vertical and oblique scenes for actual operations. The purpose of… more
Abstract:The study addresses the need for better physician training by providing specific accurate clinical descriptions of pigmented lesions including malignant melanoma. In Phase I, we will develop clinical algorithms to precisely describe malignant melanoma. In this phase, our aims include 1) location of… more
Abstract:THE OBJECTIVE OF THIS PROPOSED RESEARCH IS TO DEVELOP A CAD-BASED EXPERT SYSTEM FOR THE DESIGN OF STRUCTURAL REPAIRSAND FOR THE DETAILED DESIGN OF STRUCTURAL MEMBERS. THE SYSTEM WILL COUPLE VARIATIONAL GEOMETRY, AUTOMATED FINITE ELEMENT MESH GENERATION AND DESIGN SENSITIVITY ANALYSIS INTO A TOOL… more
Abstract:DEEP UV AND I-LINE LITHOGRAPHY WILL BE USED EXTENSIVELY THROUGHOUT THE 1990'S TO BUILD SUBMICRON INTEGRATED CIRCUITS. RECENT STUDIES WITH COMMERCIAL DEEP UV AND I-LINEPHOTORESISTS HAVE SHOWN THAT THEIR PERFORMANCE FALLS DRAMATICALLY WHEN PRINTING OVER REFLECTIVE SUBSTRATES SUCH AS POLYSILICON AND… more
Abstract:LIGHT SIGNALS PASS THROUGH OPTICAL PROCESSORS VIA AN INTERCONNECTING SYSTEM OF WAVE GUIDE STRUCTURES. FLUORINATED POLYMERS, BECAUSE OF THEIR OUTSTANDING PROPERTIES, ARE LOGICAL MATERIALS FOR USE IN FABRICATING THESE STRUCTURES. FLUOROPOLYMERS CAN BE PAIRED WITH OTHER PLASTICS OR CERAMICS OF HIGHER… more
Abstract:COLOR FILTER FABRICATION IS ONE OF THE MOST EXPENSIVE STEPS IN THE MANUFACTURE OF COLOR LCD DISPLAYS. COLOR FILTER FORMATION IS USUALLY ACCOMPLISHED BY A PHOTOLITHOGRAPHIC PROCESS WHICH REQUIRES A NUMBER OF STEPS. THE YIELD IS LOW AND LABOR AND MATERIAL COSTS ARE RELATIVELY HIGH. IN ADDITION, THE… more
Abstract:BACTERIAL EXPRESSION SYSTEMS DESIGNED TO PRODUCE LARGE AMOUNTS OF PROTEINS FOR MEDICAL, INDUSTRIAL OR RESEARCH USE ARE STAPLES IN THE REPERTOIRE OF RECOMBINANT DNA TECHNOLOGY. ONE REQUIREMENT IS THAT THE PROTEIN BE EASILY PURIFIED AND IN AS ACTIVE A FORM AS POSSIBLE. WE WILL USE A CLONED RECOMBINANT… more
Abstract:THE USE OF ORDER RESTRICTED STATISTICAL INFERENCE IS VERY LIMITED, PARTIALLY DUE TO THE DIFFICULTY IN THE UNDERSTANDING AND ALGORITHMIC APPROACH OF THE THEORY. THIS PROPOSAL WILL RESEARCH ON THE IMPLEMENTATION OF REGRESSION ANALYSIS AND LINEAR MODELS INTO ORDER RESTRICTED STATISTICALINFERENCE.… more
Abstract:A NEW TECHNOLOGY OF PREPARING SILICON NITRIDE AND SILICON OXYNITRIDE GLASS FIBERS IS PROPOSED. CONTINUOUS SILICON NITRIDE AND OXYNITRIDE FIBERS WILL BE PREPARED AT LOW PROCESSING TEMPERATURES AND AT LOW MATERIAL, EQUIPMENT AND OPERATING COST. SILICA AND OTHER SELECTED POROUS HIGH SILICA (NANOMETER… more
Abstract:ORGANOALUMINUM IS AN ENERGETIC MATERIAL WHICH REACTS WITH AIR OR MOISTURE. THE PURPOSE OF THIS PROPOSAL WILL BE TO FIND THE POLYMERIC THIN WALLED ENCAPSULANT WHICH WILL BE ADDRESSED BY: - DEVELOPING ENCAPSULATION TECHNIQUES WITH SEVERAL POLYMERS OR CO-POLYMERS - IDENTIFICATION OF THE PHYSICAL… more
Abstract:APPROXIMATELY 8-10% OF ALL BABIES BORN IN THE U.S.A. EACH YEAR DELIVER BEFORE 37 WEEKS GESTATION. CURRENT HIGH RISK SCORING TOOLS WHICH ATTEMPT TO IDENTIFY PREGNANT WOMEN AT RISK FOR PRETERM LABOR HAVE PROBLEMS WITH RELIABILITY AND VALIDITY, AND REPORTED STUDIES USING THESE TOOLS ACHIEVE ONLY 18-44%… more
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