Abstract:Medical robotic applications require numerous actuation devices that must be both lightweight and efficient. In the case of mobile medical robotics, Space, Weight, and Power efficiency (SWaP) are the key performance attributes for most designs. The objective of this proposal is to design and… more
Abstract:DESCRIPTION (provided by applicant): A rapid method for concentrating bacteria from real apple juice and spinach wash water into a small volume, which is easily analyzed by advanced detectors, will enable rapid detection of small numbers of bacteria and provide for improved consumer safety and… more
Abstract:Detection of bioaerosols is a cornerstone in the protection of our nation from bioterrorist events. Rapid bioaerosol detection systems
have advanced dramatically in recent years, but the lack of integratable automated sample preparation for these systems remains a
major deficiency. Three significant… more
Abstract:Shock-wave/boundary-layer interactions (SWBLI) pose challenges to aeronautical engineers because they create regions of adverse pressure gradients as a result of the discontinuous change in conditions across the shock. This shock-induced pressure gradient is a common factor for both flow separation… more
Abstract:DESCRIPTION (provided by applicant): The purpose of this SBIR project is to develop a new dual-modality inflammation imaging technology to early detect Uveitis, an ocular inflammation-related disorder. This technology, based on nanocomposites (NCs) that function as dual-modality fluorescent and… more
Abstract:DESCRIPTION (provided by applicant): Nitric oxide (NO) has been shown to have powerful, broad-spectrum antimicrobial activity as well as benefits in wound healing when properly administered [1-3]. The combination of these two attributes makes development of a non-systemic NO delivery approach… more
Abstract:DESCRIPTION (provided by applicant): Atrial fibrillation (AF) is the most prevalent clinical arrhythmia in clinical practice and a major contributor to morbidity and mortality. A recent study estimated that the number of Americans afflicted by AF will increase from the current range of 2.2 to 5.6… more
Abstract:DESCRIPTION (provided by applicant): Cells secrete hormones and neurotransmitter via exocytosis. Understanding how exocytosis is regulated and how pharmaceuticals and toxins inhibit exocytosis is of broad medical significance. The overall goal of this SBIRproject is to use microfabrication… more
Abstract:The androgen receptor (AR) remains a key therapeutic target for prostate cancer (PCa), even in castration resistant PCa (CRPC). Current therapies target AR by blocking androgen synthesis or competitive antagonism. ARTA Bioscience is developing an early lead, ABS-001, a non-competitive AR inhibitor… more
Abstract:Invention House LLC proposes to lower the initial cost of solar energy by minimizing the material used in the reflector of a concentrating trough. Placing the support structure on the front (sun) side and using a thin reflecting membrane will reduce material usage and cost by approximately 66%. The… more
Abstract:HyBeacons Probe Assays for the Detection of Ticks and Tick-Borne Pathogens Patrick Williams, Ph.D., Evogen Inc., 8301 State Line Road, Kansas City, MO 64114 The proposed development will evaluate the use of Evogen"s HyBeacons probes for rapid, multiplexed vector and pathogen detection using… more
Abstract:Akermin proposes, in collaboration with the University of New Mexico, to demonstrate the viability of electronic connections between biomolecules and engineered surfaces in order to harvest power and energy through biologic systems. This work is in part based on Akermin's proprietary enzyme… more
Abstract:This SBIR Phase I project will develop an enzymatic bio-fuel cell using a unique enzyme stabilization technology. The technology overcomes the stability and lifetime issues faced by conventional bio-fuel cells where rare metals serve as the catalyst. Development of the bioanode for the fuel cell… more
Abstract:DESCRIPTION (provided by applicant): Secondary metabolites will be extracted from a specific plant material to identify and isolate immune active components. These components are proposed to enhance the innate and adaptive immune systems by modulating cert
ain cytokine levels in white blood cells… more
Abstract:DESCRIPTION (provided by applicant): Diabetes costs the United States an estimated 174 billion annually. About two-thirds of costs arise from direct medical expenditures, and the remainder accrues from disability, work loss, and premature mortality. Assoc
iated cardiovascular comorbidities result… more
Abstract:DESCRIPTION (provided by applicant): Identifying the regulatory regions of the genome is critical for understanding the regulatory networks underlying human development and disease. Chromatin immunoprecipitation (ChIP) coupled with microarray (ChIP-chip)
or sequencing (ChIP- seq) is a widely used… more
Abstract:Many of the antibodies produced for cancer research are poorly characterized, exhibit suboptimal affinity or selectivity, and are time-consuming and expensive to produce. Alternative affinity capture reagents are therefore needed as reproducible, highly characterized, rapid, and cost-effective… more
Abstract:DESCRIPTION (provided by applicant): The Patch Clamp technique has evolved in recent years from an esoteric method of basic electrophysiological research into properties of cell membranes, into a practical technique for mass screening compounds for potenti
ally therapeutic pharmaceutical properties.… more
Abstract:Crosslink proposes to develop a two-layer protective coating system for the protection of aircraft canopies and transparencies that meets the Air Force requirements for electrical and optical performance, durability, adhesion, and light transmission. The Crosslink system will utilize an organic… more
Abstract:The objective of this proposal is to demonstrate the feasibility of producing a multi-node communication network with low latency for use in the hardware-in-the-loop (HWIL) test environment. In the HWIL environment, multi-node connectivity latencies ideally would be at or near zero to prevent the… more
Abstract:How much energy can be saved by opening a window instead of running an air conditioner? How does this affect the air quality of a home? With rising energy costs and as concern for the environment grows more widespread, the need to conserve energy resources is becoming more apparent. Although many… more
Abstract:The importance of fast, reliable detection of pathogens in drinking water in the United States and worldwide, is increasing rapidly due to rising populations and increasing environmental degradation, as well as the threat of terrorism. Although the technology readiness level of rapid detection… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project aims to develop a new photoresist material with dual tones for micro-photolithography. Traditional photoresist material responds to radiations in either positive or negative tone respectively. In this project, a dual-tone photoresist… more
Abstract:DESCRIPTION (provided by applicant): Human apyrase represents a highly promising therapy for acute ischemic stroke which is a leading cause of death and disability with almost no effective therapy for most patients. Using a protein informatics approach, we
have successfully engineered a human… more
Abstract:DESCRIPTION (provided by applicant): Human apyrase represents a highly promising therapy for acute ischemic stroke which is a leading cause of death and disability with almost no effective therapy for most patients. This enzyme strongly inhibits platelet a
ctivation and aggregation with modest… more
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